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化合物库

位置: 首页 > 化合物库
A-Z Index: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
化合物库
  • Nuclear-receptor inhibitors library(L1510)

    简述:Nuclear receptorsare a class ofproteins, different from membrane receptors located in the cell membrane,found within cells that are responsible for sensingsteroidandthyroidhormonesand certain other molecules.Nuclear receptors have the ability to directly bind toDNAand regulate the expression of adjacent genes, hence these receptors are classified astranscription factors, thereby controlling thedevelopment,homeostasis, andmetabolism of the organism. Over the last 15 years a growing number of nuclear receptors have been identified that coordinate genetic networks regulating lipid metabolism and energy utilization andunderlie the pathogenesis of metabolic diseases, such as obesity, type II diabetes, hypertension, and cardiovascular disease. SAB collects 239 reported compounds targeting nuclear receptors as Nuclear Receptor Compound Library, which can be used for research in nuclear receptor signaling and related diseases, and high throughput and high content screening for drug discovery

    Nuclear-receptor inhibitors library
  • Anti-cancer approved drug library(L2110)

    简述:During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 313 approved anti-cancer drugs based on published literatures and database to form this collection that can be used as positive controls in biological cancer investigation and cancer correlation study

    Anti-cancer approved drug library
  • Anti-cancer clinical compound library(L2120)

    简述:During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 560 anti-cancer compounds currently in clinical trial phases based on published literatures and database to form this collection that can be used for high throughput screening and high content screening.

    Anti-cancer clinical compound library
  • Anti-cancer metabolism compound library(L2130)

    简述:Cancer metabolismhas emerged as an important area ofresearchin recent years. Reprogramming of the cellular energy metabolism, essential for cancer cell proliferation and tumor development, constitutes an emerging hallmark of cancer and may serve as a biochemical basis for new therapeutic intervention. From the abnormal aerobic glycolysis effect in tumor cells was first discovered by German scientist Warburg in the early 1920s to now on all aspects of tumor metabolic activity (sugar, fat, amino acids, etc.) analysis and complex metabolic regulation network discovery, the study of tumor metabolism has entered into a more striking height. Distinct metabolic pathways (glycolysis and glutaminolysis), key regulators of aerobic glycolysis (AMPK, mTOR, HIF-1, c-Myc, p53, etc.), and key metabolism enzymes (PKM, HK, PFK, PK, IDH, GLS) might be the key targets for tumor therapeutics. Developing inhibitors targeting dysregulated metabolic enzymes and pathways may represent a promising strategy to overcome drug resistance in cancer therapy. A unique collection of 130 cancer cellular metabolism related compounds by SAB can be used for cancer related research and high throughput and high content screening for anti-cancer drugs.

    Anti-cancer metabolism compound library
  • Promoting Cancer cell differentiation compound lirary(L2140)

    简述:Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. In cancer, this describes how much or how little tumor tissue looks like the normal tissue it came from. Well-differentiated cancer cells look more like normal cells and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells. Differentiation is used in tumor grading systems, which are different for each type of cancer. In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis. SAB collects 251 reported compounds inducing cancer cell differentiation as Promoting Cancer Cell Differentiation Compound Library, which can be used for high throughput and high content screening for drug discovery.

    Promoting Cancer cell differentiation compound lirary
  • Anti-cancer Drug library(L2150)

    简述:During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 822 anticancer drugs including FDA approved and compounds in clinical trial phases as Anticancer Drug Library that can be used for tumor-related research and anti-tumor drug screening

    Anti-cancer Drug library
  • Anti-cancer Active Compound library(L2160)

    简述:During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 1081 compounds with known anti-tumor activity as Anticancer Active Compound Library that can be used for tumor-related research and anti-tumor drug screening

    Anti-cancer Active Compound library
  • Approved Drug Library (L1000)

    简述:Compound Libraries

    Approved Drug Library
  • Protease Inhibitor Library(L1100)

    简述:Compound Libraries

    Protease Inhibitor Library
  • Epigenetics Inhibitor Library
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