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APP antibody

38604
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  货号 规格 价格
38604-1 50ul ¥1200.00元
38604-2 100ul ¥2000.00元

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产品详情
  • 产品名称 APP antibody
  • 来源种属 Rabbit
  • 克隆性 Polyclonal
  • 纯化 Antibodies were purified by affinity purification using immunogen.
  • 应用 WB
  • 种属反应性 Human,Mouse
  • 特异性The antibody detects endogenous level of total APP antibody.
  • 免疫原类型Peptide
  • 免疫原描述 A synthetic peptide of human APP.
  • 基因/蛋白名称 APP
  • 别名 AAA;AD1;PN2;ABPP;APPI;CVAP;ABETA;PN-II;
  • 数据库入口号 Swiss-Prot#: P05067
    NCBI Gene ID: 351
  • 实际分子量 87kd
  • 浓度 1.0mg/ml
  • 配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 保存 Store at -20˚C
应用详情

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200

图片
  • APP antibody - SAB | Signalway Antibody

    Western blot analysis of extracts of SKOV3 cells, using APP antibody at 1:1000 dilution.

背景
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
  • et al,Oral Treponema denticola Infection Induces Aβ1�?0 and Aβ1�?2 Accumulation in the Hippocampus of C57BL/6 Mice. In J Mol Neurosci on 2021 Jul by Xinyi Su 1, Zhiqun Tang, et al..PMID: 33763842, , (2021),
    PMID: 33763842
  • et al,Study of mitophagy and ATP-related metabolomics based on β-amyloid levels in Alzheimer's disease. In Exp Cell Res on 2020 Nov 1 by Xiaomin Xiong, Shijie Li, et al..PMID: 32905804, , (2020),
    PMID: 32905804
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      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
    • IP免疫沉淀
    • E酶联免疫吸附法
    • DB免疫斑点法
    • ChIP染色质免疫沉淀
    • GICA胶体金免疫层析法
    • NC阴性对照
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