产品详情
产品名称Tau(Phospho-Thr205) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB IHC
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of Tau only when phosphorylated at threonine 205.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of threonine 205 (P-G-T(p)-P-G) derived from Human Tau.
基因/蛋白名称Tau
修饰Phospho
别名MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
数据库入口号Swiss-Prot: P10636
NCBI Protein: NP _001116538.1
UniprotP10636
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
背景
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
del C Alonso A, et al. (2004) J Biol Chem; 279(33): 34873-81
Li G, Yin H, Kuret J (2004) J Biol Chem; 279(16): 15938-45
Giasson BI, et al. (2002) Biochemistry; 41(51): 15376-87
Liu F, et al. (2002) FEBS Lett; 530(1-3): 209
Taniguchi T, et al. (2001) J Biol Chem; 276(13): 10025-31
如果您使用该产品11108发表了文章，请通知我们，让我们可以引用您的文献。
et al,Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology. In Prog Neurobiol on 2021 Nov by Maria Rosaria Tropea,
Domenica D Li Puma,et al..PMID:34453977,
, (2021),
PMID: 34453977
et al,A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. In Signal Transduct Target Ther on 2021 Jul 14 by Jie Zheng, Na Tian
et al..PMID:34262014,
, (2021),
PMID: 34262014
et al,Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. In Cell Stem Cell
on 2020 Mar 5 by Jie Zheng, Hong-Lian Li,et al..PMID:31978364,
, (2020),
PMID: 31978364
et al,Liraglutide Ameliorates HyperhomocysteInemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular TargetIng. In Neurosci Bull on 2019 Jan 10 by Zhang Y, Xie JZ, et al..PMID: 30632006,
, (2019),
PMID: 30632006
et al,Trillium tschonoskii maxim extract attenuates abnormal Tau phosphorylation.Neural Regen Res.In Neural Regen Res.On 2018 May by Luo HB, Shang N. et al..PMID: 29863023,
, (2018),
PMID: 29863023
et al,Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348,
, (2018),
PMID:
28646348
et al,Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway. In Neurochem Res.On 2018 Feb by Xu ZP, Gan GS et al..PMID: 29098530,
, (2018),
PMID:
29098530
查看更多
et al,Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes .In Mol Neurobiolon 2016 Sep by Ao-Ji Xie, En-Jie Liu et al..PMID: 26377105,
, (2016),
PMID: 26377105
et al,Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5.In Mol Neurobiol.On 2016 Jan by Li K, Liu FF et al..PMID:25465240,
, (2016),
PMID: 25465240
et al,Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease.In Transl Psychiatry on 2016 Oct 4 by S-S Jiao , L-L Shen et al..PMID:27701410 ,
, (2016),
PMID: 27701410
et al,Extrasynaptic NMDA Receptor-Induced Tau Overexpression Mediates Neuronal Death Through Suppressing Survival Signaling ERK Phosphorylation.In Cell Death Dis on 2016 Nov 3 by Xu-Ying Sun , Qing-Zhang Tuo et al..PMID: 27809304,
, (2016),
PMID: 27809304
et al,Region-specific expression of tau, amyloid-尾 protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.In J Alzheimers Dis on 2014 by Li Lin, Shu-Sheng Yang, et al..PMID: 24787918,
, (2014),
PMID: 24787918
et al,Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.In J Neurochem on 2012 Jan by Chen LM,
Xiong YS,et al..PMID:21496024,
, (2012),
PMID: 21496024
et al,Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). In J Biol Chem on 2012 Mar 30 by Xu-Ying Sun, Yu-Ping Wei, et al..PMID: 22334661
,
, (2012),
PMID: 22334661
Tan Wenfei, Cao Xuezhao, Wang Junke et al,Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.,
European Journal of Anaesthesiology, 27(9):835-841. doi: 10.1097/EJA.0b013e32833a6561 (2010),
PMID: 20485178
et al,Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.In Eur J Anaesthesiol on 2010 Sep by Tan W, Cao X, et al..PMID:20485178,
, (2010),
PMID: 20485178
et al,Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats.In
Clin Exp Pharmacol Physiol on 2010 Oct by Tan WF, Cao XZ,et al..PMID:20659131,
, (2010),
PMID: 20659131
有货
