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Caspase 12 Antibody#48277

Caspase 12 Antibody
Caspase 12 Antibody
是否有货: Yes
产品总价:
产品详情

产品名称Caspase 12 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Immunogen affinity purified

应用WB, IP, IF

种属反应性Hu, Ms, Rt

免疫原描述peptide

别名CASP 12 antibody
CASP-12 antibody
Casp12 antibody
CASP12P1 antibody
caspase 12 (gene/pseudogene) antibody
caspase 12 pseudogene 1 antibody
CASPC_HUMAN antibody
Inactive caspase-12 antibody
OTTHUMP00000207032 antibody

数据库入口号Swiss-Prot#:O08736

计算分子量50kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:100-1,000


IP: 1-2 ug per 100-500 ug of total protein (1ml of cell lysate)
Western blot analysis of caspase-12 expression in BC3H1 (A) and UV-treated NIH/3T3 (B) whole cell lysates.
Immunofluorescence staining of methanol-fixed BC3H1 cells showing cytoplasmic localization.
背景
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase-5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.
背景文献
1. Maddalena, F., et al. 2011. Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca2+ homeostasis. Cancer Res. 71: 7659-7669.
2. .Fatma, N., et al. 2011. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am. J. Physiol., Cell Physiol. 301: C954-C967.

如果您使用该产品48277发表了文章,请通知我们,让我们可以引用您的文献。

et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681, , (2021),
PMID: 33604681
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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