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TGF-Beta 1 Antibody#48569

TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
TGF-Beta 1 Antibody
是否有货: Yes
产品总价:
产品详情

产品名称TGF-Beta 1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Peptide affinity purified

应用WB, ICC, IHC, FC

种属反应性Hu, Ms, Rt, Zebrafish

免疫原描述peptide

别名Cartilage-inducing factor antibody
CED antibody
Differentiation inhibiting factor antibody
DPD1 antibody
LAP antibody
Latency-associated peptide antibody
Prepro transforming growth factor beta 1 antibody
TGF beta 1 antibody
TGF beta antibody
TGF beta 1 protein antibody
TGF-beta 1 protein antibody
TGF-beta-1 antibody
TGF-beta-5 antibody
TGF-beta1 antibody
TGFB antibody
Tgfb-1 antibody
tgfb1 antibody
TGFB1_HUMAN antibody
TGFbeta antibody
TGFbeta1 antibody
Transforming Growth Factor b1 antibody
Transforming Growth Factor beta 1 antibody
Transforming growth factor beta 1a antibody
transforming growth factor beta-1 antibody
transforming growth factor, beta 1 antibody
Transforming Growth Factor-?1 antibody

数据库入口号Swiss-Prot#:P01137

计算分子量44 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:500-1:1,000
IHC: 1:200
ICC: 1:200

FC:1:100
Western blot analysis of TGF-Beta 1 on different cell lysates using anti- TGF-Beta 1 antibody at 1/1000 dilution. Positive control:
Lane 1: Raji
Lane 2: MCF-2
Lane 3: A549
Lane 4: Human kidney
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TGF-Beta 1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-TGF-Beta 1 antibody. Counter stained with hematoxylin.
ICC staining TGF-Beta 1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining TGF-Beta 1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining TGF-Beta 1 in SKBR-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of HepG2 cells with TGF-Beta 1 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Goat anti rabbit IgG (FITC) was used as the secondary antibody.
背景
Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT. Interacts with ASPN. Function: TGF beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Tissue specificity: TGF beta 1 is highly expressed in bone. A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly.
背景文献

1. "A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro." McGowan N.W., MacPherson H., Janssens K., Van Hul W., Frith J.C., Fraser W.D., Ralston S.H., Helfrich M.H. J. Clin. Endocrinol. Metab. 88:3321-3326(2003)

2. "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes." Finnson K.W., Tam B.Y.Y., Liu K., Marcoux A., Lepage P., Roy S., Bizet A.A., Philip A. FASEB J. 20:1525-1527(2006)

3. "Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm." Lindsay M.E., Schepers D., Bolar N.A., Doyle J.J., Gallo E., Fert-Bober J., Kempers M.J., Fishman E.K., Chen Y., Myers L., Bjeda D., Oswald G., Elias A.F., Levy H.P., Anderlid B.M., Yang M.H., Bongers E.M., Timmermans J. , Braverman A.C., Canham N., Mortier G.R., Brunner H.G., Byers P.H., Van Eyk J., Van Laer L., Dietz H.C., Loeys B.L. Nat. Genet. 44:922-927(2012)

如果您使用该产品48569发表了文章,请通知我们,让我们可以引用您的文献。

et al,Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish. In Cell Commun Signal on 2022 Oct 19 by Shanshan Liu, Ting Chen, et al..PMID: 36261846, , (2022),
PMID: 36261846
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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