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ZO1 Antibody#48588

ZO1 Antibody
ZO1 Antibody
ZO1 Antibody
是否有货: Yes
产品总价:
产品详情

产品名称ZO1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Peptide affinity purified

应用ICC, IHC

种属反应性Hu, Ms, Rt

免疫原描述peptide

别名Tight junction protein 1 antibody
Tight junction protein ZO-1 antibody
Tight junction protein ZO1 antibody
TJP1 antibody
zo-1 antibody
Zo1 antibody
ZO1_HUMAN antibody
Zona occludens 1 antibody
Zona occludens 1 protein antibody
Zona occludens protein 1 antibody
Zonula occludens 1 protein antibody
Zonula occludens protein 1 antibody

数据库入口号Swiss-Prot#:Q07157

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

IHC: 1:200
ICC: 1:200

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-ZO1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-ZO1 antibody. Counter stained with hematoxylin.
ICC staining ZO1 in MCF-7 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. ZO1 plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
背景文献
1. "Evidence for a functional interaction between cingulin and ZO-1 in cultured cells." D'Atri F., Nadalutti F., Citi S. J. Biol. Chem. 277:27757-27764(2002)
2. "Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells." Sallee J.L., Burridge K. J. Biol. Chem. 284:14997-15006(2009)
3. "Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration." Huo L., Wen W., Wang R., Kam C., Xia J., Feng W., Zhang M. EMBO J. 30:665-678(2011)

如果您使用该产品48588发表了文章,请通知我们,让我们可以引用您的文献。

et al,Bacterial endotoxin-induced maternal inflammation leads to fetal intestinal injury and affects microbial colonization in the neonatal period. In J Matern Fetal Neonatal Med on 2021 May 31 by Qingmei Huang, Siliang Lu,et al..PMID:34058958, , (2021),
PMID: 34058958
et al,Lipopolysaccharide-Induced Chorioamnionitis Induces Fetal Intestinal Injury and Affects Gut Colonization in Rats , , (2020),
PMID:
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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