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位置: 首页 > 重组兔单抗 > Caspase-1 Rabbit mAb

Caspase-1 Rabbit mAb#48847

评价
Recombinant
Caspase-1 Rabbit mAb
Caspase-1 Rabbit mAb
Caspase-1 Rabbit mAb
Caspase-1 Rabbit mAb
Caspase-1 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称Caspase-1 Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆性SU40-07

纯化ProA affinity purified

应用WB, IHC, FC

种属反应性Hu, Ms, Rt

免疫原描述recombinant protein

别名CASP-1 antibody
CASP1 antibody
CASP1_HUMAN antibody
Caspase 1 antibody
Caspase-1 subunit p10 antibody
ICE antibody
IL-1 beta-converting enzyme antibody
IL-1BC antibody
IL1 beta converting enzyme antibody
IL1B convertase antibody
Interleukin 1 beta convertase antibody
Interleukin 1B converting enzyme antibody
Interleukin-1 beta convertase antibody
Interleukin-1 beta-converting enzyme antibody
p45 antibody

数据库入口号Swiss-Prot#:P29466

计算分子量45 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200


FC: 1:50-1:100
Western blot analysis of Caspase-1 on different lysates using anti-Caspase-1 antibody at 1/1,000 dilution.

Positive control:

Lane 1: THP-1

Lane 2: Jurkat

Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with Caspase-1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
背景
Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.
背景文献
1. Zhao J et al. Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats. PLoS One 10:e0140772 (2015).
2. Zhang X et al. Porcine Mx1 fused to HIV Tat protein transduction domain (PTD) inhibits classical swine fever virus infection in vitro and in vivo. BMC Vet Res 11:264 (2015).

如果您使用该产品48847发表了文章,请通知我们,让我们可以引用您的文献。

et al,Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor 伪-mediated autophagy. In J Adv Res on 2020 Aug 24 by Qinghai Meng, Yu Li,et al..PMID:33364052, , (2021),
PMID: 33364052
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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