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NLRP3 Rabbit mAb

49012
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  货号 规格 价格
49012-1 50ul ¥2000.00元
49012-2 100ul ¥3000.00元

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产品详情
  • 产品名称 NLRP3 Rabbit mAb
  • 来源种属 Recombinant Rabbit
  • 克隆性 Monoclonal antibody
  • 克隆号 SC06-23
  • 纯化 ProA affinity purified
  • 应用 WB, ICC/IF, IHC, IP, FC
  • 种属反应性 Hu, Ms, Rt
  • 免疫原描述 recombinant protein
  • 别名 AGTAVPRL antibody
    AII/AVP antibody
    Angiotensin/vasopressin receptor AII/AVP like antibody
    Angiotensin/vasopressin receptor AII/AVP-like antibody
    C1orf7 antibody
    Caterpiller protein 1.1 antibody
    CIAS 1 antibody
    CIAS1 antibody
    CLR1.1 antibody
    Cold autoinflammatory syndrome 1 antibody
    Cold autoinflammatory syndrome 1 protein antibody
    Cryopyrin antibody
    Familial cold autoinflammatory syndrome antibody
    FCAS antibody
    FCU antibody
    LRR and PYD domains-containing protein 3 antibody
    Muckle-Wells syndrome antibody
    MWS antibody
    NACHT antibody
    NACHT LRR and PYD containing protein 3 antibody
    NALP 3 antibody
    NALP3 antibody
    NALP3_HUMAN antibody
    NLRP3 antibody
    PYPAF 1 antibody
    PYPAF1 antibody
    PYRIN containing APAF1 like protein 1 antibody
    PYRIN-containing APAF1-like protein 1 antibody
  • 数据库入口号 Swiss-Prot#:Q96P20
  • 计算分子量 118/85 kDa
  • 配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 保存 Store at -20˚C
应用详情

WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:500

FC: 1:50-1:100

图片
  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


  • NLRP3 Rabbit mAb - SAB | Signalway Antibody


背景
Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).
背景文献
1. Qiao J et al. Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation. Sci Rep 5:17828 (2015).
2. Ataide MA et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014).
  • et al,Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.In Front Pharmacol on 2021 Sep 2 by Zixiu Liu, Taiyang Liao, et al.., , (2021),
    PMID: 34539417
  • et al,Interventional Efects of the Topical of "Sanse Powder" Essential Oils Nanoemulsion on Knee Osteoarthritis in Rats by Targeting the ERS/TXNIP/NLRP3 Signaling Axis.In Front Pharmacol on 2021 Sep 2 by Zixiu Liu, Taiyang Liao, et al..PMID: 34539417, , (2021),
    PMID: 34539417
  • et al,Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-kB signaling and NLRP3 inflammasome . In Eur J Pharmacol on 2020 Sep 15 by Yonger Chen , Yingyu Lu, et al..PMID:32710952, , (2020), , (2020),
    PMID: 32710952
  • et al,Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway. In Int Immunopharmacol on 2020 Aug by Mi Tian, Pei Ma, et al..PMID: 32521491, , (2020),
    PMID: 32521491
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    注释
      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
    • IP免疫沉淀
    • E酶联免疫吸附法
    • DB免疫斑点法
    • ChIP染色质免疫沉淀
    • GICA胶体金免疫层析法
    • NC阴性对照
      种属反应性:
    • Hu
    • Ms小鼠 
    • Rt大鼠 
    • Dm果蝇
    • C线虫
    • Mk
    • Rb
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