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位置: 首页 > 重组兔单抗 > Progesterone Receptor Rabbit mAb

Progesterone Receptor Rabbit mAb#49338

评价
Recombinant
Progesterone Receptor Rabbit mAb
Progesterone Receptor Rabbit mAb
Progesterone Receptor Rabbit mAb
Progesterone Receptor Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称Progesterone Receptor Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆性JF0549

纯化ProA affinity purified

应用WB, ICC/IF, IHC, IP

种属反应性Hu

免疫原描述recombinant protein

别名NR3C3 antibody
Nuclear receptor subfamily 3 group C member 3 antibody
PGR antibody
PR antibody
PRA antibody
PRB antibody
PRGR_HUMAN antibody
Progesterone receptor antibody
Progestin receptor form A antibody
Progestin receptor form B antibody

数据库入口号Swiss-Prot#:P06401

计算分子量99 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-Progesterone Receptor antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Progesterone Receptor antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Progesterone Receptor antibody. Counter stained with hematoxylin.
ICC staining Progesterone Receptor in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell. Phosphorylation of human PR occurs on at least nine serine residues. Phosphorylation of three of the residues is hormone-inducible (Ser 102, Ser 294 and Ser 345); the others are basal but hormone-stimulated.
背景文献
1. Bondi CD et al. The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice. Eur J Obstet Gynecol Reprod Biol 174:80-5 (2014).
2. Yu Y et al. Prostate stromal cells express the progesterone receptor to control cancer cell mobility. PLoS One 9:e92714 (2014).

如果您使用该产品49338发表了文章,请通知我们,让我们可以引用您的文献。

et al,Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway. In Animals (Basel) on 2022 May 8 by Dejun Xu, Xiaohan Jiang, et al..PMID:35565639, , (2022),
PMID: 35565639
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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