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NQO1 Rabbit mAb

49364
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  货号 规格 价格
49364-1 50ul ¥2000.00元
49364-2 100ul ¥3000.00元

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产品详情
  • 产品名称 NQO1 Rabbit mAb
  • 来源种属 Recombinant Rabbit
  • 克隆性 Monoclonal antibody
  • 克隆号 JF440-1
  • 纯化 ProA affinity purified
  • 应用 WB, ICC/IF, IP, FC
  • 种属反应性 Hu, Ms, Rt
  • 免疫原描述 recombinant protein
  • 别名 Azoreductase antibody
    Cytochrome b 5 reductase antibody
    DHQU antibody
    DIA 4 antibody
    DIA4 antibody
    Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) antibody
    Diaphorase (NADH/NADPH) antibody
    Diaphorase 4 antibody
    Dioxin inducible 1 antibody
    DT diaphorase antibody
    DT-diaphorase antibody
    DTD antibody
    Menadione reductase antibody
    NAD(P)H dehydrogenase [quinone] 1 antibody
    NAD(P)H dehydrogenase quinone 1 antibody
    NAD(P)H menadione oxidoreductase 1 dioxin inducible antibody
    NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1 antibody
    NAD(P)H:menadione oxidoreductase 1 antibody
    NAD(P)H:Quinone acceptor oxidoreductase type 1 antibody
    NAD(P)H:quinone oxidoreductase 1 antibody
    NAD(P)H:quinone oxireductase antibody
    NMOR 1 antibody
    NMOR I antibody
    NMOR1 antibody
    NMORI antibody
    NQO 1 antibody
    NQO1 antibody
    NQO1_HUMAN antibody
    Phylloquinone reductase antibody
    QR 1 antibody
    QR1 antibody
    Quinone reductase 1 antibody
  • 数据库入口号 Swiss-Prot#:P15559
  • 计算分子量 31/27 kDa
  • 配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • 保存 Store at -20˚C
应用详情

WB: 1:1,000-5,000

ICC: 1:50-1:200
IP: 1:50
FC: 1:50-1:100

图片
  • NQO1 Rabbit mAb - SAB | Signalway Antibody

    Western blot analysis of NQO1 on different lysates using anti-NQO1 antibody at 1/1,000 dilution. Positive control:
    Lane 1: SH-SY-5Y
    Lane 2: Mouse kidney
    Lane 3: Raji

  • NQO1 Rabbit mAb - SAB | Signalway Antibody

    Flow cytometric analysis of Hela cells with NQO1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody

背景
NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones, using either NADH or NADPH as the electron donor. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. Many tumors overexpress NQO1, which is an obligate two-electron reductase that deactivates toxins and activates bioreductive anticancer drugs. NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals and radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression and coordinated induction of NQO1. ARE activation by tert-butylhydroquinone is dependent on PI3-kinase, which lies upstream of Nrf2. Nrf2, c-Jun, Nrf1, Jun-B and Jun-D bind to the ARE and regulate expression and induction of NQO1 gene. Maf-Maf homodimers and possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE and do not repress NQO1 transcription.
背景文献
1. Greco T et al. Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity. J Cereb Blood Flow Metab 36:1603-13 (2016).
2. Kigoshi Y et al. CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2. Sci Rep 5:12857 (2015).
  • et al,Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-kB pathways. In Chem Biol Interact on 2021 Aug 1 by Yong-Er Chen , Shi-Jie Xu et al..PMID:33974900, , (2021), , , (2021), , (2021),
    PMID: 33974900
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      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
    • IP免疫沉淀
    • E酶联免疫吸附法
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