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位置: 首页 > 重组兔单抗 > PPAR gamma Rabbit mAb

PPAR gamma Rabbit mAb#49371

评价
Recombinant
PPAR gamma Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称PPAR gamma Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆性JF101-4

纯化ProA affinity purified

应用WB

种属反应性Hu, Ms, Rt

免疫原描述recombinant protein

别名CIMT1 antibody
GLM1 antibody
NR1C3 antibody
Nuclear receptor subfamily 1 group C member 3 antibody
OTTHUMP00000185032 antibody
OTTHUMP00000185036 antibody
Peroxisome proliferator activated nuclear receptor gamma variant 1 antibody
Peroxisome proliferator activated receptor gamma 1 antibody
Peroxisome Proliferator Activated Receptor gamma antibody
Peroxisome proliferator-activated receptor gamma antibody
PPAR gamma antibody
PPAR-gamma antibody
PPARG antibody
PPARG_HUMAN antibody
PPARG1 antibody
PPARG2 antibody
PPARgamma antibody

数据库入口号Swiss-Prot#:P37231

计算分子量58 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:1,000-1:2,000



Western blot analysis of PPAR gamma on PC-12 cells lysates using anti-PPAR gamma antibody at 1/1,000 dilution.
背景
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. PPARs form heterodimers with retinoid X receptors (RXRs). These heterodimers regulate transcription of genes involved in insulin action, adipocyte differentiation, lipid metabolism and inflammation. PPARγ is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPARγ activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPARγ may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPARγ2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPARγ2 gene maybe correlated with abdominal obesity in type 2 diabetes.
背景文献
1. Yu P et al. Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine. PLoS One 11:e0154949 (2016).
2. Yu YH et al. PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation. PLoS One 11:e0161993 (2016).

如果您使用该产品49371发表了文章,请通知我们,让我们可以引用您的文献。

et al,Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner. In Ren Fail on 2022 Dec by Jun-Yu Wei, Miao-Yue Hu,et al..PMID:36420656, , (2022),
PMID: 36420656
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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