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位置: 首页 > 重组兔单抗 > RPE65 Rabbit mAb

RPE65 Rabbit mAb#49495

评价
Recombinant
RPE65 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称RPE65 Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆性JM61-51

纯化ProA affinity purified

应用WB, IP

种属反应性Hu, Ms, Rt

免疫原描述recombinant protein

别名All-trans-retinyl-palmitate hydrolase antibody
LCA 2 antibody
LCA2 antibody
Leber congenital amaurosis antibody
mRPE 65 antibody
mRPE65 antibody
p63 antibody
rd 12 antibody
rd12 antibody
Retinal pigment epithelium specific 61 kDa protein antibody
Retinal pigment epithelium specific 65 kDa protein antibody
Retinal pigment epithelium specific protein antibody
Retinal pigment epithelium specific protein 65kDa antibody
Retinal pigment epithelium-specific 65 kDa protein antibody
Retinitis pigmentosa 20 antibody
Retinoid isomerohydrolase antibody
Retinol isomerase antibody
RP 20 antibody
RP20 antibody
RPE 65 antibody
RPE65 antibody
RPE65_HUMAN antibody
sRPE 65 antibody
sRPE65 antibody

数据库入口号Swiss-Prot#:Q16518

计算分子量61 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:1,000-1:2,000


IP: 1:10-1:50
Western blot analysis of RPE65 on mouse eyeball cells lysates using anti-RPE65 antibody at 1/500 dilution.
背景
The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65kDa protein belonging to the beta-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2.
背景文献
1. Zhou J et al. Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. J Biol Chem 290:27215-27 (2015).
2. Sukseree S et al. Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice. PLoS One 11:e0161640 (2016).

如果您使用该产品49495发表了文章,请通知我们,让我们可以引用您的文献。

et al,Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury. In Aging (Albany NY) on 2020 Aug 28 by Jing-Yao Song, Bin Fan,et al..PMID: 32858529, , (2020),
PMID: 32858529
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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