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KHK Isoform A Antibody#21708

KHK Isoform A Antibody
KHK Isoform A Antibody
是否有货: 有货
产品总价:
产品详情

产品名称KHK Isoform A Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB IHC

种属反应性Hu

特异性The antibody detects endogenous level of total KHK Isoform A protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.90~95 (T-T-G-S-V) derived from Human KHK Isoform A .

别名Ketohexokinase; Hepatic fructokinase; KHK

数据库入口号Swiss-Prot#: P50053-2
NCBI Gene ID: 3795
NCBI Protein#: NP_000212.1

UniprotP50053-2

计算分子量33kd

浓度1.0mg/mL

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C

应用详情
Western blotting: 1:500-1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from Hepatocytee,Hep3B and Huh7 cells using KHK Isoform A Antibody #21708.(Reference: Nat Cell Biol. 2016 May;18(5):561-71.) .
Immunohistochemical analysis of tumors derived from Huh-7cells using KHK Isoform A Antibody #21708 (left) or the same antibody preincubated with blocking peptide (right). (Reference: Nat Cell Biol. 2016 May;18(5):561-71.)
背景
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
 
Bonthron D.T., Brady N., Donaldson I.A., Steinmann B.Hum. Mol. Genet. 3:1627-1631(1994) 

如果您使用该产品21708发表了文章,请通知我们,让我们可以引用您的文献。

et al,Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. In JHEP Rep on 2020 Nov 20 by Emma L Shepherd, Raquel Saborano, et al..PMID:33490936, , (2021),
PMID: 33490936
et al,IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. In Cell Signal on 2021 Oct by Jie Zhou, Jie Yang,et al..PMID:34252535, , (2021),
PMID: 34252535
et al,The small intestine shields the liver from fructose-induced steatosis. In Nat Metab on 2020 Jul by Cholsoon Jang, Shogo Wada, et al..PMID: 32694791, , (2020),
PMID: 32694791
et al,Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. In Nat Commun on 2020 Oct 28 by Jiyoung Kim, Jengmin Kang, et al..PMID:33116123, , (2020),
PMID: 33116123
et al,Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation, , (2020),
PMID:
et al,Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. In Cell Metab on 2020 Jul 7 by Ana Andres-Hernando, David J Orlicky, et al..PMID:32502381, , (2020),
PMID: 32502381
et al,Prognostic Impact of Metabolism ReprogrammIng Markers Acetyl-CoA Synthetase 2 Phosphorylation and KetohexokInase-A Expression In Non-Small-Cell Lung CarcInoma. In Front Oncol on 2019 Nov 5 by Yang X, Shao F, et al..PMID:31750240, , (2019),
PMID: 31750240
查看更多
Li X, Qian X, Peng LX et al et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nat Cell Biol., 18(5):561-71. (2016 May),
PMID: 27088854 WB IHC
et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854 , , (2016),
PMID: 27088854
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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