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KHK Isoform A Antibody

21708
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21708 100ul ¥2000.00元

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产品详情
  • 产品名称 KHK Isoform A Antibody
  • 来源种属 Rabbit
  • 克隆性 Polyclonal
  • 纯化 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 应用 WB IHC
  • 种属反应性 Hu
  • 特异性The antibody detects endogenous level of total KHK Isoform A protein.
  • 免疫原类型Peptide-KLH
  • 免疫原描述 Peptide sequence around aa.90~95 (T-T-G-S-V) derived from Human KHK Isoform A .
  • 别名 Ketohexokinase; Hepatic fructokinase; KHK
  • 数据库入口号 Swiss-Prot#: P50053-2
    NCBI Gene ID: 3795
    NCBI Protein#: NP_000212.1
  • 计算分子量 33kd
  • 浓度 1.0mg/mL
  • 配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 保存 Store at -20°C
应用详情

Western blotting: 1:500-1000
Immunohistochemistry: 1:50~1:100

图片
  • KHK Isoform A Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from Hepatocytee,Hep3B and Huh7 cells using KHK Isoform A Antibody #21708.(Reference: Nat Cell Biol. 2016 May;18(5):561-71.) .

  • KHK Isoform A Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of tumors derived from Huh-7cells using KHK Isoform A Antibody #21708 (left) or the same antibody preincubated with blocking peptide (right). (Reference: Nat Cell Biol. 2016 May;18(5):561-71.)

背景
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
 
Bonthron D.T., Brady N., Donaldson I.A., Steinmann B.Hum. Mol. Genet. 3:1627-1631(1994) 
  • et al,The small intestine shields the liver from fructose-induced steatosis. In Nat Metab on 2020 Jul by Cholsoon Jang, Shogo Wada, et al..PMID: 32694791, , (2020),
    PMID: 32694791
  • et al,Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. In Nat Commun on 2020 Oct 28 by Jiyoung Kim, Jengmin Kang, et al..PMID:33116123, , (2020),
    PMID: 33116123
  • et al,Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation, , (2020),
    PMID:
  • et al,Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. In Cell Metab on 2020 Jul 7 by Ana Andres-Hernando, David J Orlicky, et al..PMID:32502381, , (2020),
    PMID: 32502381
  • et al,Prognostic Impact of Metabolism ReprogrammIng Markers Acetyl-CoA Synthetase 2 Phosphorylation and KetohexokInase-A Expression In Non-Small-Cell Lung CarcInoma. In Front Oncol on 2019 Nov 5 by Yang X, Shao F, et al..PMID:31750240, , (2019),
    PMID: 31750240
  • Li X, Qian X, Peng LX et al et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation, Nat Cell Biol., 18(5):561-71. (2016 May),
    PMID: 27088854 WB IHC
  • et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854 , , (2016),
    PMID: 27088854
  • 如果您使用该产品21708发表了文章,请 通知我们 ,让我们可以引用您的文献。
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      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
    • IP免疫沉淀
    • E酶联免疫吸附法
    • DB免疫斑点法
    • ChIP染色质免疫沉淀
    • GICA胶体金免疫层析法
    • NC阴性对照
      种属反应性:
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    • Dm果蝇
    • C线虫
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