产品详情
产品名称KHK Isoform A Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB IHC
种属反应性Hu
特异性The antibody detects endogenous level of total KHK Isoform A protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.90~95 (T-T-G-S-V) derived from Human KHK Isoform A .
别名Ketohexokinase; Hepatic fructokinase; KHK
数据库入口号Swiss-Prot#: P50053-2
NCBI Gene ID: 3795
NCBI Protein#: NP_000212.1
UniprotP50053-2
计算分子量33kd
浓度1.0mg/mL
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C
应用详情
Western blotting: 1:500-1000
Immunohistochemistry: 1:50~1:100
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et al,Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. In JHEP Rep on 2020 Nov 20 by Emma L Shepherd, Raquel Saborano, et al..PMID:33490936,
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et al,IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. In Cell Signal on 2021 Oct by Jie Zhou, Jie Yang,et al..PMID:34252535,
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PMID: 34252535
et al,The small intestine shields the liver from fructose-induced steatosis. In Nat Metab on 2020 Jul by Cholsoon Jang, Shogo Wada, et al..PMID: 32694791,
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et al,Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. In Nat Commun on 2020 Oct 28 by Jiyoung Kim, Jengmin Kang, et al..PMID:33116123,
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et al,Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation,
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et al,Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. In Cell Metab on 2020 Jul 7
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et al,Prognostic Impact of Metabolism ReprogrammIng Markers Acetyl-CoA Synthetase 2 Phosphorylation and KetohexokInase-A Expression In Non-Small-Cell Lung CarcInoma. In Front Oncol on 2019 Nov 5 by Yang X, Shao F, et al..PMID:31750240,
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查看更多
Li X, Qian X, Peng LX et al et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation,
Nat Cell Biol., 18(5):561-71. (2016 May),
PMID: 27088854 WB IHC
et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854 ,
, (2016),
PMID: 27088854