产品详情
产品名称JAK1(Phospho-Tyr1022) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB IHC
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of JAK1 only when phosphorylated at tyrosine 1022.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of tyrosine 1022 (K-E-Y(p)-Y-T) derived from Human JAK1.
基因/蛋白名称JAK1
修饰Phospho
别名 Janus kinase 1
数据库入口号Swiss-Prot: P23458
NCBI Protein: NP_002218.2
UniprotP23458
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 130kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
背景
Tyrosine kinase of the non-receptor type, involved in the IFN-a/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Zheng H, et al.(2005)Mol Cell Proteomics. 4(6):721-730.
Wang R, et al.(2003) Arch Biochem Biophys. 410(1): 7-15.
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et al,Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c鈥怣yc signaling.In Stem Cells on 2010 Sep by Young Cha ,
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