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ACVR1 Conjugated Antibody

C43627
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  货号 规格 价格
C43627-AF350 100ul ¥3000.00元
C43627-AF405 100ul ¥3000.00元
C43627-AF488 100ul ¥3000.00元
C43627-AF555 100ul ¥3000.00元
C43627-AF594 100ul ¥3000.00元
C43627-AF647 100ul ¥3000.00元
C43627-AF680 100ul ¥3000.00元
C43627-AF750 100ul ¥3000.00元
C43627-Biotin 100ul ¥3000.00元

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产品详情
  • 产品名称 ACVR1 Conjugated Antibody
  • 来源种属 Rabbit
  • 克隆性 Polyclonal
  • 种属反应性 Hu Ms Rt
  • 特异性The antibody detects endogenous levels of total ACVR1 protein.
  • 免疫原描述 Synthetic peptide of human ACVR1
  • 标记 Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
  • 激发/发射波长AF350: 346nm/442nm
    AF405: 401nm/421nm
    AF488: 493nm/519nm
    AF555: 555nm/565nm
    AF594: 591nm/614nm
    AF647: 651nm/667nm
    AF680: 679nm/702nm
    AF750: 749nm/775nm
  • 别名 FOP;ALK2;SKR1;TSRI;ACTRI;ACVR1A;ACVRLK2
  • 数据库入口号 Swiss-Prot#:Q04771
    NCBI Gene ID:90
    NCBI mRNA#:
    NCBI Protein#:NP_001096
  • 计算分子量 57
  • 浓度
  • 配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
  • 保存 Store at 4˚Cin dark for 6 months
应用详情

Suggested Dilution:
AF350 conjugated: most applications: 1: 50 - 1: 250
AF405 conjugated: most applications: 1: 50 - 1: 250
AF488 conjugated: most applications: 1: 50 - 1: 250
AF555 conjugated: most applications: 1: 50 - 1: 250
AF594 conjugated: most applications: 1: 50 - 1: 250
AF647 conjugated: most applications: 1: 50 - 1: 250
AF680 conjugated: most applications: 1: 50 - 1: 250
AF750 conjugated: most applications: 1: 50 - 1: 250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000

背景
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
  • et al,Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling. In Sci Adv on 2020 Jun 12 by Ziad Julier, Rezvan Karami, et al..PMID:32582857, , (2020),
    PMID: 32582857
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