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位置: 首页 > 磷酸化抗体 > HDAC4(Phospho-Ser632) Antibody

HDAC4(Phospho-Ser632) Antibody#11192

HDAC4(Phospho-Ser632) Antibody
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产品总价:
产品详情

产品名称HDAC4(Phospho-Ser632) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 632 (A-Q-S(p)-S-P) derived from Human HDAC4.

基因/蛋白名称HDAC4

修饰Phospho

别名HD4

数据库入口号Swiss-Prot: P56524
NCBI Protein: NP_006028.2

UniprotP56524

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 140kd
Western blotting: 1:500~1:1000
 

Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with EGF(lane 2) using HDAC4(Phospho-Ser632) Antibody #11192.
背景

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.
Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.
 

如果您使用该产品11192发表了文章,请通知我们,让我们可以引用您的文献。

S Lim, M Luo, M Koh et al,Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ?-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone., Molecular and Cellular Biology, 27(11):4105-4120 (2007),
PMID: 17371839
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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