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DR5 Antibody#24041

DR5 Antibody
DR5 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称DR5 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Affinity chromatography purified via peptide column

应用ELISA WB ICC

种属反应性Hu Ms

特异性Antibody has no cross reaction to DR4.

免疫原类型Peptide

免疫原描述Raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor.

基因/蛋白名称DR5

别名DR5, TRAIL-R2

数据库入口号AF012535

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.
背景
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.

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et al, Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway.In Oncotarget on 2016 Nov 8 by Sai-Qi Wang , Cong Wang et al..PMID: 27659528, , (2016),
PMID: 27659528
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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