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CASR Antibody#46408

CASR Antibody
CASR Antibody
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产品总价:
产品详情

产品名称CASR Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification

应用WB IHC

种属反应性Hu

特异性The antibody detects endogenous levels of total CASR protein.

免疫原类型peptide

免疫原描述Synthetic protein corresponding to residues near the C terminal of human CASR

基因/蛋白名称CASR

别名CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1

数据库入口号Swiss-Prot:P41180
NCBI Gene ID:846
NCBI Protein:BC112236

计算分子量121 kDa

浓度0.7mg/ml

配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 50-300
Gel: 6%SDS-PAGE
lysate: 40 ¦Ìg, Lane: Hela cell lysate,
Primary antibody: 46408£¨CASR Antibody) at dilution 1/450
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 2 minutes
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46408(CASR Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200)
背景
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

如果您使用该产品46408发表了文章,请通知我们,让我们可以引用您的文献。

et al,Acetylcholine protects mesenteric arteries against hypoxia/reoxygenation injury via inhibiting calcium-sensing receptor.In J Pharmacol Sci on 2015 Apr by Ming Zhao , Xi He et al..PMID:25922231 , , (2015),
PMID: 25922231
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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