产品详情
产品名称KRCC1 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB, IHC
种属反应性Hu, Ms
免疫原描述Fusion protein of human KRCC1
基因/蛋白名称KRCC1
别名CHBP2
数据库入口号Swiss-Prot#: Q99726
NCBI Protein#: BC015927
计算分子量31 kDa
浓度1.7mg/ml
配方pH7.4 PBS, 0.05% NaN3, 40% Glycerol
保存Store at -20˚C/1 year
应用详情
WB dilution:1:500-1:2000
IHC dilution:1:100-1:300
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Mouse kidney tissue lysates, Primary antibody:KRCC1 Antibody at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using (KRCC1 Antibody) at dilution 1/95.
背景
KRCC1 (lysine-rich coiled-coil 1), also known as CHBP2 (cryptogenic hepatitis-binding protein 2), is a 259 amino acid protein that is encoded by a gene located on human chromosome 2p11.2. Consisting of 237 million bases, chromosome 2 is the second largest human chromosome and encodes over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr?m syndrome, is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.