产品详情
产品名称LYVE1 Conjugated Antibody
来源种属Rabbit
克隆性Monoclonal
克隆性JF0979
纯化ProA affinity purified
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
别名Cell surface retention sequence-binding protein 1 antibody CRSBP 1 antibody CRSBP-1 antibody CRSBP1 antibody extracellular link domain containing 1 antibody extracellular link domain-containing 1 antibody Extracellular link domain-containing protein 1 antibody HAR antibody Hyaluronic acid receptor antibody Lymphatic endothelium specific hyaluronan receptor antibody lymphatic vessel endothelial hyaluronan receptor 1 antibody Lymphatic vessel endothelial hyaluronic acid receptor 1 antibody LYVE 1 antibody LYVE-1 antibody LYVE1 antibody LYVE1_HUMAN antibody XLKD1 antibody
数据库入口号Swiss-Prot#:Q9Y5Y7
计算分子量35 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
背景
Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation.
背景文献