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位置: 首页 > 抗体 > Anti-LIMK1(Ab-508) antibody

Anti-LIMK1(Ab-508) antibody#21151

Anti-LIMK1(Ab-508) antibody
Anti-LIMK1(Ab-508) antibody
是否有货: Yes
产品总价:
产品详情

产品名称Anti-LIMK1(Ab-508) antibody

来源种属Rabbit

亚型Immunogen-specific rabbit IgG

纯化Antigen affinity purification

应用WB IHC

种属反应性Human,Mouse,Rat

免疫原描述Synthetic peptide of human LIMK1

别名LIMK; LIMK-1

数据库入口号Swiss-Prot#:P53667

计算分子量73 kDa

浓度0.8mg/ml

配方pH7.4 PBS, 0.05% NaN3, 40% Glycerol

保存'-20°C

应用详情

WB dilution: 500-2000

IHC dilution: 30-150

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: HUVEC cell lysate Primary antibody: LIMK1(Ab-508) Antibody at dilution 1/350 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 30 seconds
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using LIMK1(Ab-508) Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
背景

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

 

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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