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位置: 首页 > 抑制剂 > Crizotinib (PF-02341066)

Crizotinib (PF-02341066)#S1661

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称Crizotinib (PF-02341066)

简述Inhibitors

纯化98.97%

生物活性Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung Y (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.

基因/蛋白名称ALK inhibitor; c-Met/HGFR inhibitor

CAS号877399-52-5

计算分子量450.34

配方C21H22Cl2FN5O

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述

Research Area:Cancer
SMILES:C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
Receptor:ALK; c-Met
Boling pt:599.18C
Melting pt:
Solubility:DMSO: 9 mg/mL (19.98 mM)
Appearance:White Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

背景文献

1. Zou HY, et al. Y Res. 2007, 67(9), 4408-4417.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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