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位置: 首页 > 抑制剂 > SB525334

SB525334#S1763

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称SB525334

简述Inhibitors

纯化98.39%

生物活性SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

基因/蛋白名称TGF-beta/Smad inhibitor

CAS号356559-20-1

计算分子量343.42

配方C21H21N5

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述

Research Area:Other
SMILES:CC1=CC=CC(=N1)C1=C(N=C(N1)C(C)(C)C)C1=CC2=NC=CN=C2C=C1
Pathways:Stem Cells
Receptor:TGFβR1(ALK5)
Boling pt:
Melting pt:
Solubility:Ethanol: 68 mg/mL (198.0 mM); DMSO: 68 mg/mL (198.0 mM)
Appearance:Yellow Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

背景文献

1. Grygielko ET, et al. J Pharmacol Exp Ther, 2005, 313(3), 943-951.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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