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位置: 首页 > 抗体 > HDAC4(Ab-632) Antibody

HDAC4(Ab-632) Antibody#21141

HDAC4(Ab-632) Antibody
HDAC4(Ab-632) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称HDAC4(Ab-632) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB IF

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of total HDAC4 protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa. 630~634 (A-Q-S-S-P) derived from Human HDAC4.

基因/蛋白名称HDAC4

别名HD4; Histone deacetylase 4;

数据库入口号Swiss-Prot: P56524
NCBI Protein: NP_006028.2

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 140kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from HepG2 cells using HDAC4(Ab-632) Antibody #21141.
Immunofluorescence staining of methanol-fixed Hela cells using HDAC4(Ab-632) Antibody #21141.
背景
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.
Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.

如果您使用该产品21141发表了文章,请通知我们,让我们可以引用您的文献。

et al,Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats.In Biochem Biophys Res Commun on 2016 Jan 15 by Satoshi Kameshima, Muneyoshi Okada et al..PMID:26697749, , (2016),
PMID: 26697749
et al,Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair. In Oncotarget on 2016 Feb 2 by Pei Chen, Na Yu, et al..PMID:26756218, , (2016),
PMID: 26756218
et al,Anticancer effects of sodium butyrate on hepatocellular carcinoma cells in vitro. In Int J Mol Med on 2013 Apr by Hong-Gang Wang, Xiao-Dan Huang, et al..PMID: 23440283, , (2013),
PMID: 23440283
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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