4AA9 reacts with CD45, a 180-220 kDa leukocyte common antigen (LCA). CD45 antigen is expressed at high levels on all hematopoietic cells including T and B lymphocytes, monocytes, granulocytes, NK cells and dendritic cells, but is not expressed on non-hematopoietic cells. CD45 antibody has also been reported to react weakly with mature blood erythrocytes and platelets. CD45 is a protein tyrosine phosphatase receptor that is critically important for T and B cell antigen receptor-mediated activation.
*Target of immunosuppresive antibody treatment.
1. Knapp, W et al., eds. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.
2. Trowbridge, IS and Thomas, ML. (1993) Annu. Rev. Immunol. 12:85.
3. Pulido, R et al., (1988) J. Immunol. 140:3851.
4. Roach, T et al., (1997) Curr. Biol. 7:408.
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