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位置: 首页 > 抗体 > IkB-a(Ab-42) Antibody

IkB-a(Ab-42) Antibody#21176

IkB-a(Ab-42) Antibody
IkB-a(Ab-42) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IkB-a(Ab-42) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB IHC

种属反应性Hu Ms

特异性The antibody detects endogenous level of total IkB-a protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkB-a.

基因/蛋白名称IkB-a

别名I-kappa-B-alpha; IKBA; NF-kappaB inhibitor alpha; NFKBI; NFKBIA

数据库入口号Swiss-Prot: P25963
NCBI Protein: NP_065390.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 39kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from 293 and THP1 cells using IkB-a(Ab-42) Antibody #21176.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-a(Ab-42) Antibody #21176(left) or the same antibody preincubated with blocking peptide(right).
背景
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

B

如果您使用该产品21176发表了文章,请通知我们,让我们可以引用您的文献。

et al,Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.In Parasitol Res on 2015 Feb by Qiang Mao, Zhizhi Xie et al..PMID: 25413629, , (2015),
PMID: 25413629
et al,Perfluorocarbon Attenuates Lipopolysaccharide-Mediated Inflammatory Responses of Alveolar Epithelial Cells in Vitro.In Chin Med J (Engl) on 2011 Aug by Shu-Feng Xu, Ping Wang,et al..PMID:21933601, , (2011),
PMID: 21933601
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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