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位置: 首页 > 抗体 > PEK/PERK (Ab-981) Antibody

PEK/PERK (Ab-981) Antibody#33247

PEK/PERK (Ab-981) Antibody
PEK/PERK (Ab-981) Antibody
PEK/PERK (Ab-981) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称PEK/PERK (Ab-981) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

应用WB IHC IF/ICC ELISA

种属反应性Hu

特异性The antibody detects endogenous levels of total PEK/PERK protein.

免疫原类型Peptide

免疫原描述Synthesized non-phosphopeptide derived from human PEK/PERK around the phosphorylation site of threonine 981 (R-H-T(p)-G-Q).

基因/蛋白名称PEK/PERK

别名E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK

数据库入口号Swiss-Prot: Q9NZJ5
NCBI Gene ID: 9451

UniprotQ9NZJ5

实际分子量125kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

IF/ICC 1:100-1:500

ELISA 1:20000-1:40000

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PEK/PERK (Ab-981) antibody #33247.
Western blot analysis of extracts from MCF-7 cells, using PEK/PERK (Ab-981) antibody #33247.
Western blot analysis of extracts from JK cells (Lane 2), using PEK/PERK (Ab-981) antiobdy #33247. The lane on the left is treated with synthesized peptide.
背景

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity.

Shi Y., J. Biol. Chem. 274:5723-5730(1999).
Sood R., Biochem. J. 346:281-293(2000).
Delepine M., Nat. Genet. 25-406-409(2000).

如果您使用该产品33247发表了文章,请通知我们,让我们可以引用您的文献。

et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681, , (2021),
PMID: 33604681
et al,Quercetin Stimulates Mitochondrial Apoptosis Dependent on Activation of Endoplasmic Reticulum Stress in Hepatic Stellate Cells .In Pharm Biol. On 2016 Dec by Liwei He , Xianbang Hou et al..PMID:27572285 , , (2016),
PMID: 27572285
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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