Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes By similarity. Acts as a transcriptional activator or repressor By similarity. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' By similarity. When overexpressed, promotes cells to enter into S phase and proliferation

Do HJ, et al.Biochem Biophys Res Commun. 2007 Feb 16;353(3):770-5.
Boyer LA, et al.Cell. 2005 Sep 23;122(6):947-56.
Freberg CT, et al. Mol Biol Cell. 2007 May;18(5):1543-53.
Chambers I, et al. Cell. 2003 May 30;113(5):643-55.