产品详情
产品名称FKHRL1(Ab-253) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of total FKHRL1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.251~255(A-V-S-M-D) derived from Human FKHRL1.
基因/蛋白名称FKHRL1
别名FOXO3A; FOXO2;
数据库入口号Swiss-Prot: O43524
NCBI Protein: NP_001446.1
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 97kd
Western blotting: 1:500~1:1000
背景
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E.Cell 96:857-868(1999)
Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B.E., DiBacco S., de la Iglesia N., Gygi S.P., Blackwell T.K., Bonni A.Cell 125:987-1001(2006)
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PMID: 23085572