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位置: 首页 > 抗体 > MCL1 Antibody

MCL1 Antibody#21440

MCL1 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称MCL1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Rt

特异性The antibody detects endogenous level of total MCL1 protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.148~152(N-N-T-S-T) derived from Human MCL1.

基因/蛋白名称MCL1

别名TM; EAT; MCL1L; BCL2L3; mcl1/EAT

数据库入口号Swiss-Prot: Q07820
NCBI Protein: NP_068779.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 42kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Raji, JK, HL-60 cells using MCL1 Antibody #21440.
背景
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Bingle C.D., Craig R.W., Swales B.M., Singleton V., Zhou P., Whyte M.K.B.J. Biol. Chem. 275:22136-22146(2000)
Zhang D., Li F., Weidner D., Mnjoyan Z.H., Fujise K.J. Biol. Chem. 277:37430-37438(2002)
Leu J.I.-J., Dumont P., Hafey M., Murphy M.E., George D.L.Nat. Cell Biol. 6:443-450(2004)

如果您使用该产品21440发表了文章,请通知我们,让我们可以引用您的文献。

et al,miR-137 and miR-197 induce apoptosis and suppress tumorigenicity by targeting MCL-1 in multiple myeloma.In Clin Cancer Res on 2015 May 15 by Yijun Yang , Fei Li et al..PMID:25724519 , , (2015),
PMID: 25724519
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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