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BCL2A1 Antibody

35596
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  货号 规格 价格
35596-1 50ul ¥1200.00元
35596-2 100ul ¥2000.00元

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产品详情
  • 产品名称 BCL2A1 Antibody
  • 来源种属 Rabbit
  • 克隆性 Polyclonal
  • 纯化 Antigen affinity purification.
  • 应用 WB IHC
  • 种属反应性 Hu Ms
  • 特异性The antibody detects endogenous levels of total BCL2A1 protein.
  • 免疫原类型Recombinant Protein
  • 免疫原描述 Fusion protein corresponding to a region derived from internal residues of human BCL2-related protein A1
  • 基因/蛋白名称 BCL2A1
  • 别名 GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
  • 数据库入口号 Swiss-Prot#: Q16548
    NCBI Gene ID: 597
    Gene Accssion: BC016281
  • 实际分子量 20kd
  • 浓度 0.7mg/ml
  • 配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
  • 保存 Store at -20˚C
应用详情

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

图片
  • BCL2A1 Antibody - SAB | Signalway Antibody

    Gel: 12%SDS-PAGE
    Lysates (from left to right): Mouse testis tissue and hela cell
    Amount of lysate: 40ug per lane
    Primary antibody: 1/117 dilution
    Secondary antibody dilution: 1/8000
    Exposure time: 1 minute

  • BCL2A1 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #35596 at dilution 1/20.

背景
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • et al,KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. In Am J Cancer Res on 2020 Oct 1 by Peiyang Lin, Junjing Li,et al..PMID:33163271, , (2020),
    PMID: 33163271
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      应用:
    • WB免疫印迹
    • IHC免疫组化
    • IF免疫荧光
    • ICC免疫细胞化学
    • FC流式细胞
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    • ChIP染色质免疫沉淀
    • GICA胶体金免疫层析法
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