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MLKL antibody#38674

MLKL antibody
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产品总价:
产品详情

产品名称MLKL antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were purified by affinity purification using immunogen.

应用WB,IHC,IF

种属反应性Human,Mouse

特异性The antibody detects endogenous level of total MLKL protein.

免疫原类型Recombinant Protein

免疫原描述Recombinant protein of human MLKL.

基因/蛋白名称MLKL

别名9130019I15Rik;

数据库入口号Swiss-Prot#: Q8NB16
NCBI Gene ID: 74568

UniprotQ8NB16

实际分子量54kd

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C

应用详情
Western blotting: 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using MLKL antibody at 1:1000 dilution.
背景
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

如果您使用该产品38674发表了文章,请通知我们,让我们可以引用您的文献。

et al,Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP. In Mol Cell Biochem on 2021 Aug by Qianqian Zhang, Wenge Li, et al..PMID: 33797701, , (2021),
PMID: 33797701
et al,Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis. In Biomed Res Int on 2021 Oct 28 by Feng Sun, Haiwei Zhang, et al..PMID:34746308, , (2021),
PMID: 34746308
et al,ZYZ-803 mitigates endoplasmic reticulum stress-related necroptosis after acute myocardial Infarction through downregulatIng the RIP3-CaMKII signalIng pathway. In Oxid Med Cell Longev on 2019 Jun 2 by Chang L, Wang Z, et al..PMID:31281585, , (2019),
PMID: 31281585
et al,Comprehensive Evaluation of White Matter Damage and Neuron Death and Whole-Transcriptome Analysis of Rats With Chronic Cerebral Hypoperfusion. In Front Cell Neurosci on 2019 Jul 17 by Li W, Wei D, et al..PMID:31379504, , (2019),
PMID: 31379504
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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