产品详情
产品名称BCL-XL(Ab-62) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of total BCL-XL protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .
基因/蛋白名称BCL-XL
别名Apoptosis regulator Bcl-X
数据库入口号Swiss-Prot: Q07817
NCBI Protein: NP_612815.1
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 30kd
Western blotting: 1:500~1:1000
背景
Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
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Muchmore S.W.et.al (1996).Nature 381:335-341
Yu J., Zhang L. Mol. (2001)Cell 7:673-682
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