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  • 免疫组化(IHC)

     

    Immunohistochemistry (IHC) is commonly used for in situ qualitative or quantitative analysis of a target protein in cells of a tissue section. Thought a labeled antibody that is specific to its antigen and sensitive to color-developing agent, this method is also widely used for analyzing the sub-cellular localization of a protein. SAB offers IHC applicable antibodies which have generally been validated by different tissues and various approaches. This will distinctly save your time in experiment and can avoid waste of samples.

     
    Validation Approaches Include:
          Validation by different tissues
          Blocking peptide control
         
    Human breast carcinoma tissue
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody #11014.
     
    Human Lung carcinoma tissue
    Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody #11014.

     

    Human colon carcinoma tissue

    Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using IKK α (Phospho-Thr23) Antibody #11129.
     
    Human tonsil carcinoma tissue
    Immunohistochemical analysis of paraffin-embedded human tonsil carcinoma tissue using VASP (Phospho-Ser157) Antibody #11214
     
    Rat hippocampal region tissue
    Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Tau (Phospho-Thr205) Antibody #11108.
     
    Blocking peptide control
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p56Dok-2 (Phospho-Tyr299) Antibody #11278 (left) or the same antibody preincubated with blocking peptide #51278 (right).
     

     

  • 免疫印迹(WB)

     

    Western blotting (WB) is used to analyze a target protein in a mixed sample with numerous proteins  according to the specificity of antibody against its antigen. With SDS-PAGE’s high resolution and solid-phase immunoassay’s high sensitivity and specificity, western blotting has been one of the most common methods for protein analysis. SAB follows a stringent validation protocol and uses several validation approaches in western blotting to ensure antibody quality and phospho-specificity.

     

    Validation Approaches Include:

          Phosphatase treatment

          Stimulus or inhibitor treatment

          Blocking peptide control

          Validation by various cell lines

     

    Phosphatase treatment
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody #11056.
     
    Stimulus or inhibitor treatment
    Western blot analysis of extracts from SK-BR-3 cells, untreated or insulin and EGF treated, and pretreated with U0126 and LY294002, using p44/42 MAP Kinase (Phospho-Tyr204) Antibody #11246 (upper) or p44/42 MAP Kinase Antibody #21238 (lower) .
     
    Fluorescent Western Blotting
     
    Western blot analysis of extracts from 293 cells, treated with Hydroxyurea or calf intestinal phosphatase
     (CIP), using CDC2 (Phospho-Tyr15) Antibody . #11244.
     
     
    Blocking peptide control
    Western blot analysis of extracts from Hela cells using p53 (Phospho-Ser315) Antibody #11100 (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).
     
     
    Validation by various cell lines
    Western blot analysis of extracts from various cells using PKM2 Antibody #21578.

     

  • 利用磷酸酯酶的新磷酸化特异性验证

    In order to further verify phospho-specificity and ensure quality, SAB has increased phosphatase treatment method in validation of phospho-specific antibodies. Up to the present SAB has used numerous analytical methods in antibody characterization.
             Western blotting(WB)
                      Phosphatase treatment
                      Stimulus treatment
                      Blocking peptide control
                      Loading control
                      Validation by various cell lines
             Immunohistochemistry(IHC)
                      Blocking peptide control
                      Validation with different tissues
             Immunofluorescence / Immunocytochemistry(IF/ICC)
                     Validation by various cell lines
                     Subcellular localization and co-localization analysis
             Flow cytometry(FCM)
      
             ELISA

     

    Akt(Phospho-Ser473) Antibody 11054
    Western blot analysis of extracts from 293 cells, treatedwith EGF or calf intestinal phosphatase (CIP), using Akt(Phospho-Ser473) Antibody #11054.
    MORE>

     

    PTEN(Phospho-Ser380/Thr382/Thr383) Antibody 11056
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using PTEN (Phospho-Ser380/Thr382/Thr383) Antibody #11056.
    MORE>

     

    Tau(Phospho-Ser404) Antibody 11112
    Western blot analysis of extracts from C6 cells, treated with calf intestinal phosphatase (CIP), using Tau (Phospho-Ser404) Antibody #11112.
    MORE>

     

    NFkB-p65(Phospho-Ser529) Antibody 11217
    Western blot analysis of extracts from MCF cells, treated with TNFa+CA or calf intestinal phosphatase (CIP), using NFκB-p65 (Phospho-Ser529) Antibody #11217.
    MORE>

     

    mTOR(Phospho-Ser2448) Antibody 11221
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using mTOR (Phospho-Ser2448) Antibody #11221.
    MORE>

     

     
    GSK3α (Phospho-Ser21) Antibody 11007
    Western blot analysis of extracts from 293 cells, treated with insulin or calf intestinal phosphatase (CIP), using GSK3α (Phospho-Ser21) Antibody #11007.
    MORE>

     

     

    ATF2 (Phospho-Thr73 or 55) Antibody 11032
    Western blot analysis of extracts from COS7 cells, treated with UV or calf intestinal phosphatase (CIP), using ATF2 (Phospho-Thr73 or 55) Antibody #11032.
    MORE>

     

    MEF2A (Phospho-Thr312) Antibody 11039
    Western blot analysis of extracts from C2C12 cells, treated with Anisomycin or calf intestinal phosphatase (CIP), using MEF2A (Phospho-Thr312) Antibody #11039.
    MORE>

     

    STAT1 (Phospho-Tyr701) Antibody 11044
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using STAT1 (Phospho-Tyr701) Antibody #11044.
    MORE>

     

    STAT3 (Phospho-Ser727) Antibody 11046
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using STAT3 (Phospho-Ser727) Antibody #11046.
    MORE>

     

    STAT6 (Phospho-Thr645) Antibody 11051
    Western blot analysis of extracts from Hela cells, treated with IL-4 or calf intestinal phosphatase (CIP), using STAT6 (Phospho-Thr645) Antibody #11051.
    MORE>

     

     

    Estrogen Receptor-α (Phospho-Ser118) Antibody 11072
    Western blot analysis of extracts from COS7 cells, treated with starve or calf intestinal phosphatase (CIP), using Estrogen Receptor-α (Phospho-Ser118) Antibody #11072.
    MORE>

     

    HER2 (Phospho-Tyr1221/Tyr1222) Antibody 11076
    Western blot analysis of extracts from Hela cells, treated with EGF or calf intestinal phosphatase (CIP), using HER2 (Phospho-Tyr1221/Tyr1222) Antibody #11076.
    MORE>

     

    ICAM-1 (Phospho-Tyr512) Antibody 11083
    Western blot analysis of extracts from C2C12 cells, treated with starve or calf intestinal phosphatase (CIP), using ICAM-1 (Phospho-Tyr512) Antibody #11083.
    MORE>

     

    p53 (Phospho-Ser33) Antibody 11097
    Western blot analysis of extracts from HT29 cells, treated with serum or calf intestinal phosphatase (CIP), using p53 (Phospho-Ser33) Antibody #11097.
    MORE>

     

    p53 (Phospho-Ser46) Antibody 11099
    Western blot analysis of extracts from 293 cells, treated with UV+serum or calf intestinal phosphatase (CIP), using p53 (Phospho-Ser46) Antibody #11099.
    MORE>

     

    p90RSK (Phospho-Ser352) Antibody 11113
    Western blot analysis of extracts from Hela cells, treated with PMA or calf intestinal phosphatase (CIP), using p90RSK (Phospho-Ser352) Antibody #11113.
    MORE>

     

    Androgen Receptor (Phospho-Ser650) Antibody 11120
    Western blot analysis of extracts from 293 cells, treated with PMA or calf intestinal phosphatase (CIP), using Androgen Receptor (Phospho-Ser650) Antibody #11120.
    MORE>

     

    IKK α (Phospho-Thr23) Antibody 11129
    Western blot analysis of extracts from Hela cells, treated with EGF or calf intestinal phosphatase (CIP), using IKK α (Phospho-Thr23) Antibody #11129.
    MORE>

     

    Chk1 (Phospho-Ser280) Antibody 11140
    Western blot analysis of extracts from A2780 cells, treated with calf intestinal phosphatase (CIP), using Chk1 (Phospho-Ser280) Antibody #11140.
    MORE>

     

    Src(Phospho-Tyr529) Antibody 11153
    Western blot analysis of extracts from HepG2 cells, treated with Anisomycin or calf intestinal phosphatase (CIP), using Src (Phospho-Tyr529) Antibody #11153.
    MORE>

     

    Zap-70 (Phospho-Tyr319) Antibody 11159
    Western blot analysis of extracts from HL60 cells, treated with calf intestinal phosphatase (CIP), using Zap-70 (Phospho-Tyr319) Antibody #11159.
    MORE>

     

    MEK1 (Phospho-Ser221) Antibody 11161
    Western blot analysis of extracts from Hela cells, treated with calf intestinal phosphatase (CIP), using MEK1 (Phospho-Ser221) Antibody #11161.
    MORE>

     

    HSP27 (Phospho-Ser15) Antibody 11164
    Western blot analysis of extracts from Hela cells, treated with Anisomycin or calf intestinal phosphatase (CIP), using HSP27 (Phospho-Ser15) Antibody #11164.
    MORE>

     

    AMPKα1 (Phospho-Ser487)Antibody 11174
    Western blot analysis of extracts from C6 cells, treated with EGF or calf intestinal phosphatase (CIP), using AMPKα1 (Phospho-Ser487) Antibody #11174.
    MORE>

     

    EGFR (Phospho-Thr693) Antibody 11187
    Western blot analysis of extracts from HUVEC cells, treated with starve or calf intestinal phosphatase (CIP), using EGFR (Phospho-Thr693) Antibody #11187.
    MORE>

     

    APP (Phospho-Thr668) Antibody 11190
    Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using APP (Phospho-Thr668) Antibody #11190.
    MORE>

     

    HDAC2 (Phospho-Ser394) Antibody 11191
    Western blot analysis of extracts from HepG2 cells, treated with calf intestinal phosphatase (CIP), using HDAC2 (Phospho-Ser394) Antibody #11191.
    MORE>

     

    HSF1 (Phospho-Ser307) Antibody 11195
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using HSF1 (Phospho-Ser307) Antibody #11195.
    MORE>

     

    Stathmin 1 (Phospho-Ser16) Antibody 11234
    Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using Stathmin 1 (Phospho-Ser16) Antibody #11234.
    MORE>

     

     
    CDC2 (Phospho-Tyr15) Antibody 11244
    Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using Stathmin 1 (Phospho-Ser16) Antibody #11244.
    MORE>

     

    HSP27 (Phospho-Ser82) Antibody 11248
    Western blot analysis of extracts from Hela cells, treated with UV or calf intestinal phosphatase (CIP), using HSP27 (Phospho-Ser82) Antibody #11248.
    MORE>

     

    P38 MAPK (Phospho-Thr180) Antibody 11252
    Western blot analysis of extracts from HL60 cells, treated with TNFa or calf intestinal phosphatase (CIP), using P38 MAPK (Phospho-Thr180) Antibody #11252.
    MORE>

     

    HSF1 (phospho-Ser303) Antibody 11263
    Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using HSF1 (phospho-Ser303) Antibody #11263.
    MORE>

     

    Merlin (Phospho-Ser518) Antibody 11266
    Western blot analysis of extracts from C6 cells, treated with calf intestinal phosphatase (CIP), using Merlin (Phospho-Ser518) Antibody #11266.
    MORE>

     

    Cortactin (Phospho-Tyr466) Antibody 11272
    Western blot analysis of extracts from JK cells, treated with H2O2 or calf intestinal phosphatase (CIP), using Cortactin (Phospho-Tyr466) Antibody #11272.
    MORE>

     

    p62Dok (phospho-Tyr362) Antibody 11276
    Western blot analysis of extracts from JK cells, treated with G-CSF or calf intestinal phosphatase (CIP), using p62Dok (phospho-Tyr362) Antibody #11276.
    MORE>

     

    p56Dok-2 (Phospho-Tyr299) Antibody 11278
    Western blot analysis of extracts from JK cells, treated with G-CSF or calf intestinal phosphatase (CIP), using p56Dok-2 (Phospho-Tyr299) Antibody #11278.
    MORE>

     

    PKCθ (Phospho-Ser676) Antibody 11297
    Western blot analysis of extracts from PC12 cells, treated with PMA or calf intestinal phosphatase (CIP), using PKCθ (Phospho-Ser676) Antibody #11297.
    MORE>

     

    IκB-β (Phospho-Ser23) Antibody 11304
    Western blot analysis of extracts from HT29 cells, treated with CA or calf intestinal phosphatase (CIP), using IκB-β (Phospho-Ser23) Antibody #11304.
    MORE>

     

    Keratin 8 (Phospho-Ser74) Antibody 11307
    Western blot analysis of extracts from 293 cells, treated with calf intestinal phosphatase (CIP), using Keratin 8 (Phospho-Ser74) Antibody #11307.
    MORE>

     

    Myc (Phospho-Ser62) Antibody 11311
    Western blot analysis of extracts from K562 cells, treated with calf intestinal phosphatase (CIP), using Myc (Phospho-Ser62) Antibody #11311.
    MORE>

     

    SHP-2 (Phospho-Tyr580) Antibody 11320
    Western blot analysis of extracts from 293 cells, treated with starve or calf intestinal phosphatase (CIP), using SHP-2 (Phospho-Tyr580) Antibody #11320.
    MORE>

     

    α-catenin (Phospho-Ser641) Antibody 11330
    Western blot analysis of extracts from HT29 cells, treated with serum or calf intestinal phosphatase (CIP), using α-catenin (Phospho-Ser641) Antibody #11330.
    MORE>

     

    JNK1/JNK2/JNK3 (phospho-Thr183/Tyr185) Antibody 11504
    Western blot analysis of extracts from 293 cells, treated with Anisomycin or calf intestinal phosphatase (CIP), using JNK1/JNK2/JNK3 (phospho-Thr183/Tyr185) Antibody #11504.
    MORE>

     

    MARCKS (phospho-Ser170) Antibody 11535
    Western blot analysis of extracts from 3T3 cells, treated with serum or calf intestinal phosphatase (CIP), using MARCKS (phospho-Ser170) Antibody #11535.
    MORE>

     

    Lck (phospho-Tyr505) Antibody 11537
    Western blot analysis of extracts from 293 cells, treated with calf intestinal phosphatase (CIP), using Lck (phospho-Tyr505) Antibody #11537.
    MORE>

     

    NFκB-p105/p50(Phospho-Ser337) Antibody 11017
    Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using NFκB-p105/p50(Phospho-Ser337) Antibody #11017.
    MORE>
  • 新发表文献

    Volume 35, Issue 1, January 2014, Pages 316–326

    The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy
     
    Jia Shena, b, c, 1, Guosheng Songd, 1, Man Ana, c, Xianqian Lie, Ning Wue, Kangcheng Ruana, c, Junqing Hud, Ronggui Hua, c, 
    a State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
    b University of Chinese Academy of Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
    c Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China
    d State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
    e Department of Clinical Oncology, Xuhui Central Hospital, 966 Middle Huaihai Road, Shanghai 200031, China
     
    Abstract
    Bortezomib (BTZ) is the first clinically approved proteasome inhibitor for treating multiple human malignancies. However, the poor water-solubility and low stability of BTZ and the emergence of tumor resistance have severely restrained its therapeutic efficacy. Herein, we report the application of hollow mesoporous silica nanospheres (HMSNs) in encapsulating BTZ for drug delivery. In in vitro cell viability assay on human NSCLC H1299 cells, the half-maximum inhibiting concentration (IC50) of HMSNs–BTZ was 42% of that for free BTZ in 48 h treatments. In vivo tumor-suppression assay further indicated that HMSNs–BTZ (0.3 mg/kg) showed approximately 1.5 folds stronger anti-tumor activity than free BTZ. Furthermore, we report that more potent induction of cell cycle arrest and apoptotic cell death, along with promoted activation of Caspase 3 and autophagy might mechanistically underlie the improved anti-tumor efficacy of HMSNs–BTZ. Finally, the tumor-suppressing effect of HMSNs–BTZ was enhanced in the presence of wild-type p53 signaling, suggesting a potential enhancement in clinical efficacy with combined p53 gene therapy and BTZ-based chemotherapy. Therefore, the HMSNs-based nanoparticles are emerging as a promising platform to deliver therapeutic agents for beneficial clinical outcomes through lowering doses and frequency of drug administration and reducing potential side effects.
     
    Keywords
    Anti-tumor activity; Apoptotic cell death; Bortezomib; Drug delivery; Mesoporous silica; NSCLC
     

     

  • 发表文献

    Published Papers 

     

    Cat.No.

    Product Name

    Reference

    11002

    GSK3β (Phospho-Ser9) Antibody

    Cong REN, Jia-Mou LI, Xin LIN (2010) LIPUS Enhance Elongation of Neurites in Rat Cortical Neurons through Inhibition of GSK-3β. Biomedical and Environmental Sciences, Volume 23, Issue 3, Pages 244-249

    11002

    GSK3β (Phospho-Ser9) Antibody

    Yingjuan Yang, Jinzeng Yang, Rongxin Liu, Huixia Li and Xiao Luo, et al.Accumulation of β-catenin by lithium chloride in porcine myoblast cultures accelerates cell differentiation.Molecular Biology Reports, 2011, Volume 38, Number 3, Pages 2043-2049

    11002

    GSK3b(Phospho-Ser9) Antibody

    Estefanía de Munck, Emma Mu˜noz-Sáez, Bego˜na G. Miguel, M. Teresa Solas,et al (2013)  B-N-methylamino-l-alanine causes neurological andpathological phenotypes mimicking Amyotrophic LateralSclerosis (ALS): The first step towards an experimentalmodel for sporadic ALS. environmental toxicology and pharmacology 36:243–255

    11002

    GSK3b(Phospho-Ser9) Antibody

    Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607

    11002

    GSK3b(Phospho-Ser9) Antibody

    Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17

    11002

    GSK3b(Phospho-Ser9) Antibody

    Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015

    11002

    GSK3b(Phospho-Ser9) Antibody

    Jiamou Li, Hua Zhang, Cong Ren. (2012) Effect of Low-Intensity Pulsed Ultrasound on Nerve Repair. Tissue Regeneration - From Basic Biology to Clinical Application, Prof. ISBN: 978-953-51-0387-5,

    11005

    PDK1 (Phospho-Ser241) Antibody

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,

    11005

    PDK1(Phospho-Ser241) Antibody

    Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959

    11006

    Raf1(Phospho-Ser259) Antibody

    Zhi-Xin Qiu, Lei Wang,Juan Han, Dan Liu, et al.(2012) Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer. Cancer Sci. vol. 103 no. 10 pp. 1774–1779

    11007

    GSK3α (Phospho-Ser21) Antibody

    Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164

    11011

    NFκB-p65 (Phospho-Ser276) Antibody

    Anneleen Spooren, Krzysztof Kolmus, Linda Vermeulen,et al.(2010) Hunting for Serine 276-phosphorylated p65. Journal of Biomedicine and Biotechnology, 2010, Article ID 275892, 9 doi:10.1155/2010/275892

    11011

    NFκB-p65(Phospho-Ser276) Antibody

    Xiaoping Cai, Saul Benedict Freedman, Paul Kenneth Witting.(2013) Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: inhibition by the multi-kinase inhibitor BIBF1120. doi: 10.1111/1440-1681.12148

    11014

    NFκB-p65 (Phospho-Ser536) Antibody

    Jitakshi De, Robert E. Brown (2010)Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compared with Non-Hodgkin’s lymphoma. Int J Clin Exp Med,3(1):55-68

    11015

    NFκB-p100(Phospho-Ser866) Antibody

    Chen Shen & Xin-liang Zhao &Weina Ju &Xiao-bing Zou & Li-rong Huo & Wu Yan & Jun-hua Zou &Guo-di Yan & Edmund C. Jenkins &W. Ted Brown &Nanbert Zhong,A Proteomic Investigation of B Lymphocytes in an Autistic Family: A Pilot Study of Exposure to Natural Rubber Latex (NRL) May Lead to Autism,J Mol Neurosci (2011) 43:443–452

    11021

    c-Jun(Phospho-Thr91) Antibody

    Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D. Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215

    11024

    c-Jun (Phospho-Thr239) Antibody

    Soichiro Yamamura, Kazumori Kawakami, Hiroshi Hirata,et al(2010) Oncogenic Functions of Secreted Frizzled-Related Protein 2 in Human Renal Cancer. Molecular Cancer Therapeurics

    11025

    c-Jun (Phospho-Ser243) Antibody

    Soichiro Yamamura, Kazumori Kawakami, Hiroshi Hirata,et al(2010) Oncogenic Functions of Secreted Frizzled-Related Protein 2 in Human Renal Cancer. Molecular Cancer Therapeurics

    11026

    JunB(Phospho-Ser79) Antibody

    Raffi Vartanian1, Janine Masri, Jheralyn Martin, Cheri Cloninger, et al. (2010) AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation. American Association for Cancer Research. DOI: 10.1158/1541-7786

    11027

    JunB(Phospho-Ser259) Antibody

    Raffi Vartanian1, Janine Masri, Jheralyn Martin, Cheri Cloninger, et al. (2010) AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation. American Association for Cancer Research. DOI: 10.1158/1541-7786

    11039

    MEF2A (Phospho-Thr312) Antibody

    K Satoh, J Ohnishi, A Sato, et al. (2007) Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development.Molecular and Cellular Biology, 27(21):7623-30. 

    11044

    STAT1 (Phospho-Tyr701) Antibody

    Jelke J. Fros, Wen Jun Liu, Natalie A. Prow, et al (2010)Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. Journal of Virology, 84(20)10877-10887

    11044

    STAT1 (Phospho-Tyr701) Antibody

    Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, et al(2011) Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. ‘hidabeni’ and their synthetic derivatives on LPS-induced NO production in microglia. Bioorganic & Medicinal Chemistry, Volume 19, Issue 18,  Pages 5559-5568

    11044

    STAT1(Phospho-Tyr701) Antibody

    C.-C.E. Lan, C.-S. Wu, S.-M. Huang, H.-Y. Kuo, et al.(2012) High-glucose environment reduces human b-defensin-2 expression in human keratinocytes: implications for poor diabetic wound healing. British Association of Dermatologists. 166, pp1221–1229

    11044

    STAT1(Phospho-Tyr701) Antibody

    Hsin-Chien Chen,1,2 Hsin-I Ma,1,3 Huey-Kang Sytwu,1,4 Hsing-Won Wang, Chia-Chi V. Chen,5 Shu-Chen Liu,2 Chi-Huang Chen,6 Hang-Kang Chen, and Chih-Hung Wang, Neural Stem Cells Secrete Factors That Promote Auditory Cell Proliferation Via a Leukemia Inhibitory Factor Signaling Pathway,Journal of Neuroscience Research 88:3308–3318 (2010)

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Yuan Guogang,Lu Qian ,Ming Shi (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3.Cellular Signalling, 20:1284–1291

    11045

     STAT3 (Phospho-Tyr705) Antibody

    H Yamaguchi, J Zhu, T Yu, et al. (2006) Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1  activation.Toxicology, 226:131-142.  

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Li-Nan Ren , Qing-Fang Li , Feng-Jun Xiao, et al (2009)Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein.Biochemical and Biophysical Research Communications 386:35–39  

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Jian-Guo Zhang, Jing Zhao, and Yan Xin, et al (2010) Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol. 16(5): 571–577.

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro, et al (2010)Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition. Journal of Investigative Dermatology 130, 2760-2767

    11045

     STAT3 (Phospho-Tyr705) Antibody

    Emilio García-Prieto, Adrián González-López,, Sandra Cabrera, et al (2010)Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. PloS one, 5(10): e13242.

    11045

    STAT3(Phospho-Tyr705) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    11045

    STAT3(Phospho-Tyr705) Antibody

    Feng-Ze Wanga,b, Peng-Jiaoc, Na-Na Yangc, Chuang-Yuana, Ya-Li Zhaoa, Qiang-Qiang Liua, Hong-Rong Fei d, Ji-Guo Zhang, PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells, Toxicology Letters 220 (2013) 150– 156

    11046

    STAT3 (Phospho-Ser727) Antibody

    H Yamaguchi, J Zhu, T Yu, et al. (2006) Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1  activation.Toxicology, 226:131-142.  

    11046

    STAT3 (Phospho-Ser727) Antibody

    Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.

    11046

    STAT3 (Phospho-Ser727) Antibody

    Jian-Guo Zhang, Jing Zhao, and Yan Xin, et al (2010) Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol. 16(5): 571–577.

    11046

    STAT3(Phospho-Ser727) Antibody

    ANIRBAN MAJUMDER, SASWATI BANERJEE, JOSHUA A. HARRILL, DAVID W. MACHACEK,et al (2012) Neurotrophic Effects of Leukemia Inhibitory Factor on Neural Cells Derived from Human Embryonic Stem Cells. STEM CELLS. 30:2387–2399

    11046

    STAT3(Phospho-Ser727) Antibody

    Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988

    11046

    STAT3(Phospho-Ser727) Antibody

    Feng-Ze Wanga,b, Peng-Jiaoc, Na-Na Yangc, Chuang-Yuana, Ya-Li Zhaoa, Qiang-Qiang Liua, Hong-Rong Fei d, Ji-Guo Zhang, PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells, Toxicology Letters 220 (2013) 150– 156

    11048

    STAT5a(Phospho-Tyr694) Antibody

    Drechsler J, Gro¨ tzinger J, Hermanns HM (2012) Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor. PLoS ONE 7(8): e43155. doi:10.1371/journal.pone.0043155

    11052

    anti-phospho CREB antibody

    Tomasz Boczek, Anna Kozaczuk, Bozena Ferenc, Michalina Kosiorek and Slawomir Pikula, et al.Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin.Molecular and Cellular Biochemistry, 12 September 2011

    11054

    Akt (Phospho-Ser473) Antibody

    Zhi Wang, Guotong Xu, Yalan Wu, et al. (2007) Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells.Medical and Biological Engineering and Computing, 47:41–48

    11054

    Akt (Phospho-Ser473) Antibody

    Seyoon Kim, Yong Zu Lee, Yu Sam Kim,et al (2008)A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. Proteomics, 8 (15), 3082 - 3093

    11054

    Akt (Phospho-Ser473) Antibody

    Young Yil Bahk, Ick-Hyun Cho, Tong Soo Kim. (2008)A Cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts,.Biochemical and Biophysical Research Communications, 377:1199–1204.

    11054

    Akt (Phospho-Ser473) Antibody

    Hui Zhou, Jing Zhao, Xujia Zhang. (2009)  Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytesArchives of Biochemistry and Biophysics, 486:88–93

    11054

    Akt (Phospho-Ser473) Antibody

    Jing Zhang, Osamu Yamada, Yoshihisa Matsushita, ect.(2009)Transactivation of human osteopontin promoter by human T-cell leukemia virus type 1-encoded Tax protein Leukemia Research in press.

    11054

    Akt (Phospho-Ser473) Antibody

    Li-Nan Ren , Qing-Fang Li , Feng-Jun Xiao, et al (2009)Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein.Biochemical and Biophysical Research Communications 386 (2009) 35–39

    11054

    Akt(Phospho-Ser473) Antibody

    Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272

    11054

    Akt (Phospho-Ser473) Antibody

    Sheng-Li Lin , Li-Ying Yan , Xin-Tian Zhang ,et al.(2010)ER-a36, a Variant of ER-a, Promotes Tamoxifen Agonist Action in Endometrial Cancer Cells via the MAPK/ERK and PI3K/Akt Pathways. PLoS ONE 5(2): e9013. doi:10.1371/journal.pone.0009013

    11054

    Akt (Phospho-Ser473) Antibody

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press

    11054

    Akt(Phospho-Ser473) Antibody

    Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988

    11054

    Akt(Phospho-Ser473) Antibody

    Hu Ma, Quan Yao, An-Mei Zhang, Sheng Lin, Xin-Xin Wang, Lei Wu, Jian-Guo Sun,and Zheng-Tang Chen(2011)The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model. Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556

    11054

    Akt(Phospho-Ser473) Antibody

    Marc Vendrell, Anabel Molero, Sergio Gonzalez, Kamil Perez-Capote, et al. (2011) Biotin Ergopeptide Probes for Dopamine Receptors. J. Med. Chem. 54, 1080–1090

    11054

    Akt (Phospho-Ser473) Antibody

    Yingjia Guo, Tong Yang, Jun Lu, et al (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences, Volume 88, Issues 13-14, Pages 598-605

    11054

    Akt(Phospho-Ser473) Antibody

    Lucía Callén, Estefanía Moreno, Pedro Barroso-Chinea, David Moreno-Delgado, Antoni Cortés,et al (2012) Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 25, pp. 20851–20865,

    11054

    Akt(Phospho-Ser473) Antibody

    Fang Wang a,b,1, Ting Li a,1, Bin Zhang c,1, Hong Li a, Qiong Wua, Li Yang b,⇑, Yongzhan Nie a, Kaichun Wua, Yongquan Shi a,⇑, Daiming Fan,Biochemical and Biophysical Research Communications, Biochemical and Biophysical Research Communications 434 (2013) 688–694

    11054

    anti-phospho-STAT3

    Heng-Fei Luan1*, Zhi-Bin Zhao1*, Qi-Hong Zhao2, Pin Zhu1, Ming-Yu Xiu1 and Yong Ji, Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway

    11054

    Akt(Phospho-Ser473) Antibody

    Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69

    11054

    Akt(Phospho-Ser473) Antibody

    Jia J, Xu X, Liu F, Guo X, Zhang M, et al. (2013) Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening. PLoS ONE 8(4): e59315. doi:10.1371/journal.pone.0059315

    11054

    Akt(Phospho-Ser473) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    11054

    Akt(Phospho-Ser473) Antibody

    Peter Schubert, Danielle Coupland, Brankica Culibrk, Raymond P. Goodrich, et al. (2013) Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. TRANSFUSION. Volume **, ** **

    11054

    Akt(Phospho-Ser473) Antibody

    Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881

    11054

    Akt(Phospho-Ser473) Antibody

    Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326

    11055

    Akt (Phospho-Thr308) Antibody

    Alexandra V. Andreeva, Jingyan Han, Mikhail A. Kutuzov ,et al.(2010)Journal of cellular Physiology,  223(1) 1, 94 - 102       T-cadherin modulates endothelial barrier function.

    11055

    Akt (Phospho-Thr308) Antibody

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press

    11055

    Akt(Phospho-Thr308) Antibody

    Yingjia Guo, Tong Yang, Jun Lu, Shengfu Li, et al. (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 88:598–605

    11055

    Akt(Phospho-Thr308) Antibody

    Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881

    11055

    Akt(Phospho-Thr308) Antibody

    Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83

    11055

    Akt(Phospho-Thr308) Antibody

    Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69

    11057

    p95/NBS1 (Phospho-Ser343) Antibody

    F Carrillo, SA Schneider, AMR Taylor, et al (2009) Prominent Oromandibular Dystonia and Pharyngeal Telangiectasia in Atypical Ataxia Telangiectasia. Cerebellum, 8:22–27

    11057

    p95/NBS1(Phospho-Ser343) Antibody

    Rachid Drissi, Jing Wu, Yafang Hu, Carol Bockhold, and Jeffrey S. Dome(2011)Cancer Prevention Research, 4(12) December 2011

    11059

    FAK (Phospho-Tyr861) Antibody

    Liang Wu , Lei Zhu , Wei-Hao Shi , et al. (2008) Zoledronate inhibits the proliferation,adhesion and migration of vascular smooth muscle cells.European Journal of Pharmacology, 602, 124–131

    11059

    FAK (Phospho-Tyr861) Antibody

    Baiyang Sheng, Bo Song, Zhenhuan Zheng, (2009)  Abnormal cleavage of APP impairs its functions in cell adhesion and migration.Neuroscience Letters, 450, 327–33

    11059

    FAK (Phospho-Tyr861) Antibody

     Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229

    11059

    FAK(Phospho-Tyr861) Antibody

    Masahiko Kanehira, Toshiaki Kikuchi, Shinya Ohkouchi, Taizou Shibahara, et al. (2012) Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells.PLoS ONE 7(2): e32185. doi:10.1371/journal.pone.0032185

    11062

    PTEN(Phospho-Ser370) Antibody

    Zhi Li & Gong Xiang Liu & Yu Lan Liu & Xi Chen & Xiao Li Huang & Hua Tian Gan,  Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer, Int J Colorectal Dis (2013) 28:1107–1115

    11063

    Ezrin (Phospho-Tyr353) Antibody

     Yazhou Cui, Tianliang Li, Denglu Zhang,et al.(2010)Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma. Cancer Investigation 28(3) 242-247

    11063

    Ezrin(Phospho-Tyr353) Antibody

    Yasunori Oda MD, Shinichi Aishima PhD, Katsuya Morimatsu PhD,Akifumi Hayashi PhD, et al.(2012) Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. Human Pathology 44:1487–1498

    11066

    p-Bcl-xl (Ser62)

    Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164

    11068

    BAD (Phospho-Ser136) Antibody

    N Matsuda, Y Takano, S Kageyama, et al.(2007) Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock.Cardiovascular Research,76:132-140.

    11068

    BAD (Phospho-Ser136) Antibody

    S. Otsuki, K. Sugiyama, O. Amano, T. Yasui, H. Sakagami (2011) Negative regulation of NaF-induced apoptosis by Bad–CAII complex. Toxicology, Volume 287, Issues 1-3,Pages 131-136

    11073

    Estrogen Receptor-α (Phospho-Ser167) Antibody

    Kazuyoshi Motomura, Makoto Ishitobi, Yoshifumi Komoike, et al (2010) Expression of Estrogen Receptor Beta and Phosphorylation of Estrogen Receptor Alpha Serine 167 Correlate with Progression-Free Survival in Patients with Metastatic Breast Cancer Treated with Aromatase Inhibitors. Oncology,79,1-2

    11075

    HER2(Phospho-Tyr877) Antibody

    M.Alicia Corte´s1, Ariel E.Cariaga-Martinez1,Marı´a V.T.Lobo2,3, Rosa M.Martı´n Orozco1, Omar Motin˜o1,F.Javier Rodrı´guez-Ubreva1,4, Javier Angulo5,Pilar Lo´pez-Ruiz1 and Begon˜a Cola´s1,EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway,Carcinogenesis vol.33 no.6 pp.1169–1177, 2012

    11079

    HER2 (Phospho-Tyr1248) Antibody

    Yuan Guogang,Lu Qian ,Ming Shi (2008)HER2-dependent MMP-7 expression is mediated by activated STAT3Cellular Signalling, 20:1284–1291

    11088

    anti-phospho-IGF-1R (1165/1166)

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,

    11090

    Caveolin-1 (Phospho-Tyr14) Antibody

    André Bento-Abreu, Ana Velasco, Erica Polo-Hernández,et al(2009)Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid. Journal of Neurochemistry,111 (1), Pages 49 - 60

    11092

    p53(Phospho-Ser6) Antibody

    Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect

    11098

    p53(Phospho-Ser37) Antibody

    Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect

    11100

    p53(Phospho-Ser315) Antibody

    Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect

    11102

    Tau(Phospho-Ser396) Antibody

    Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182

    11102

    Tau(Phospho-Ser396) Antibody

    Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164

    11102

    Tau(Phospho-Ser396) Antibody

    Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015

    11103

     PLCγ1 (Phospho-Tyr783) Antibody

    Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu, Thanasekaran Jayakumar, et al. (2010) Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology & Medicine. 49:881–893

    11103

    PLCgamma1(Phospho-Tyr783) Antibody

    Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607

    11106

    Tau(Phospho-Ser235) Antibody

    Johanne Bertrand, Patrick Senechal, Mathieu Zummo-Soucy, Vanessa Plouffe, et al. (2010) The formation of tau pathological pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in prinmary hippocampal neurons over-expressing human tau. JOURNAL OF NEUROCHEMISTRY. 114:1353–1367

    11107

    Tau(Phospho-Thr181) Antibody

    Lara Ordóñez-Gutiérrez, Juan María Torres, Rosalina Gavín, Marta Antón, et al. (2013) Cellular prion protein modulates b-amyloid deposition in aged APP/PS1 transgenic mice. Neurobiology of Aging. xxx:1-12

    11108

    Tau(Phospho-Thr205) Antibody

    Tan Wenfei, Cao Xuezhao,Wang Junke,et al. (2010)Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.European Journal of Anaesthesiology, doi: 10.1097/EJA.0b013e32833a6561

    11108

    Tau(Phospho-Thr205) Antibody

    Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182

    11108

    Tau(Phospho-Thr205) Antibody

    Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164

    11108

    Tau(Phospho-Thr205) Antibody

    Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced
    by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015

    11110

    Tau(Phospho-Thr231) Antibody

    Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182

    11110

    Tau(Phospho-Thr231) Antibody

    Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164

    11111

    Tau(Phospho-Ser262)Antibody

    J. Bertrand, V. Plouffe, P. Sénéchal, N. Leclerc, et al(2010) The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience, Volume 168, Issue 2, Pages 323-334

    11111

    Tau(Phospho-Ser262) Antibody

    Vanessa Plouffe. (2011) The secretion of the Tau protein: a new mechanism propagation of the pathology of Tau in the disease Alzheimer. University of Montreal Faculty of Graduate and Postdoctoral Studies.

    11112

    Tau(Phospho-Ser404) Antibody

    Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182

    11112

    Tau(Phospho-Ser404) Antibody

    Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164

    11115

    FKHR (Phospho-Ser256) Antibody

    Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.

    11115

    FKHR(Phospho-Ser256) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    11122

    ATM (Phospho-Ser1981) Antibody

    Bin Kang ,Ruifang Guo,Xiao-hui Tian , et al.(2008) Expression status of ataxia telangiectasia mutated gene coorelated with Prognosis in advanced gastric cancer.Mutation Research, 638: 17-25

    11122

    ATM (Phospho-Ser1981) Antibody

    J Leemput, C Masson, K Bigot  . ATM localization and gene expression in the adult mouse eye.Molecular Vision 15: 393–416  

    11122

    ATM(Phospho-Ser1981) Antibody

    Dashayini Mahalingam, Ling L. Tay, Wei H. Tan, Juin H. Chai, et al. (2011) Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts. FEBS Journal 278:3724–3738

    11122

    ATM(Phospho-Ser1981) Antibody

    Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J. Lamont and Atsuo Amano, Identification of Signaling Pathways Mediating Cell Cycle Arrest and Apoptosis Induced by Porphyromonas gingivalis in Human Trophoblasts, Infect. Immun. 2012, 80(8):2847. DOI: 10.1128/IAI.00258-12.

    11123

    FAK (Phospho-Tyr925) Antibody

     Z Zheng, Y Wei, et al.( 2008)Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration. Journal of Biomaterials Applications,24:209-229

    11126

    LIMK1 (Phospho-Thr508) Antibody

    Li, X., Ke, Q., Li, Y., Liu, F., Zhu, G., & Li, F., et al. (2008) DGCR6L, A Novel PAK4 Interaction Protein, Regulates PAK4-mediated migration of Human Gastric Cancer Cell via LIMK1.International Journal of Biochemistry and Cell Biology, 42: 70–79

    11130

    Rb (Phospho-Ser795) Antibody

    Fang Sun , Hanjiang Fu , Qin Liu, et al. (2008)Downregulation of CCND1 and CDK6 by miR-34a induces cell cyclearrest. FEBS Letters, 582:1564–1568.

    11130

    Rb(Phospho-Ser795) Antibody

    Heidi Braumuller, ThomasWieder, Ellen Brenner, Sonja Aßmann, et al. (2013) T-helper-1-cell cytokines drive cancer into senescence. NATURE.494:361-366

    11131

    Rb (Phospho-Ser807) Antibody

    Qin Liu, Hanjiang Fu, Fang Sun, et al. (2008) miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res., 36: 5391-5404.

    11132

    Rb(Phospho-Ser780)Antibody

    Xueting Cai, Tingmei Ye, Chao Liu, et al (2011) Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicology in Vitro, Volume 25, Issue 7,  Pages 1385-1391

    11137

    AFX (Phospho-Ser197) Antibody

    Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.

    11138

    cdc25A(Phospho-Ser76) Antibody

    Shunfu Piao,1 Su-Jin Lee,2 Yongbin Xu,1 Jungsug Gwak,3 Sangtaek Oh,3 Bum-Joon Park2,* and Nam-Chul Ha, CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation, Cell Cycle 10:3, 531-537; February 1, 2011

    11139

    cofilin(Phospho-Ser3) Antibody

    Lijun Zhang, Jun Luo, Ping Wan, Jing Wu, et al. (2011) Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development. 138:455-464

    11139

    cofilin(Phospho-Ser3) Antibody

    Guillaume Huet1, Eeva Kaisa Rajakyla, Tiina Viita1, Kari-Pekka Skarp, et al. (2012) Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool. Journal of Cell Science. 126:497–507

    11139

    cofilin(Phospho-Ser3) Antibody

    Hui Guo, Yi Lv, Tao Tian, Ting Hua Hu, et al. (2011) Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma. Carcinogenesis vol.32 no.12 pp.1897–1904

    11142

     Vav (Phospho-Tyr174) Antibody

    Yuichi Sekine,Osamu Ikeda, Satoshi Tsuji, et al (2009) Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1 -Induced Chemotaxis in T Cells. The Journal of Immunology, 183:7966 -7974

    11144

    Lck(Phospho-Tyr394) Antibody

    C. Annette Hollmanna, Alexandar Tzankovb, Verónica L. Martínez-Marignaca, Kristi Bakerc, Czeslawa Grygorczykf, Ryszard Grygorczykf, William Foulkesa,d, Jay Nadeaue, Stephan Dirnhoferb, Raquel Aloyza, Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma ,Leukemia Research 34 (2010) 585–593

    11149

    phosphorylated (p-)JAK1 (Tyr1022)

    Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164

    11149

    JAK1(Phospho-Tyr1022) Antibody

    YOUNG CHA, BO-HYUN MOON, MI-OK LEE, HEE-JIN AHN, et al. (2010) Zap70 Functions to Maintain Stemness of Mouse Embryonic Stem Cells by Negatively Regulating Jak1/Stat3/c-Myc Signaling. STEM CELLS. 28:1476–1486

    11152

    IκBα (phospho-Ser32/Ser36)

    Zhenghua Ren, Jianhua Cui, Zeren Huo, Jinru Xue,et al.(2012) Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination. International Immunopharmacology.14:698-703

    11153

    Src (Phospho-Tyr529) Antibody

    Yanhua Zheng, Yan Xia, Xiang Gao, Zhimin Lu, et al. (2009) FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST.Molecular Cell,35:11–25

    11153

    Src(Phospho-Tyr529) Antibody

    Dr. Marcia Liz.(2010-2011) Glycogen Synthase Kinase 3β modulation in axonal regeneration. Autonomous Section of Health Sciences.

    11157

    FKHRL1(Phospho-Ser253)Antibody

    Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.

    11161

     MEK1 (Phospho-Ser221) Antibody

     Akira Ikari , Kosuke Atomi , Keishi Kinjo ,et al.(2010)Magnesium deprivation inhibits a MEK–ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sciences 86: 766–773 

    11163

    STAT1(Phospho-Ser727) Antibody

    C.-C.E. Lan, C.-S. Wu, S.-M. Huang, H.-Y. Kuo, et al.(2012) High-glucose environment reduces human b-defensin-2 expression in human keratinocytes: implications for poor diabetic wound healing. British Association of Dermatologists. 166, pp1221–1229

    11164

    HSP27(Phospho-Ser15) Antibody

    Ah-Mee Park a, MasatoshiKudo b, SatoruHagiwara b, MasakiTabuchi c, TomohiroWatanabe d,Hiroshi Munakata a, ToshiharuSakurai b,n, p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression,Free RadicalBiologyandMedicine52(2012)2284–2291

    11172

    PKCβ(Phospho-Thr641) Antibody

     Jack N. Losso, Robert E. Truax,,Gerald Richard, et al (2010) trans-Resveratrol Inhibits Hyperglycemia-Induced Inflammation and Connexin Downregulation in Retinal Pigment Epithelial Cells. Journal of Agricultural and Food Chemistry, 58 (14), 8246–8252

    11177

    SEK1/MKK4(Phospho-Ser80) Antibody

    Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215

    11178

    ASK1 (Phospho-Ser83) Antibody

    Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588

    11178

    ASK1(Phospho-Ser83) Antibody

    Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D. Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215

    11179

    ASK1 (Phospho-Ser966) Antibody

    Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588

    11184

    Histone H3.1(Phospho-Ser10) Antibody

    Zenglin Liao†, Jiajia Dong†, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen, Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway, Liao et al. Respiratory Research 2012, 13:110

    11184

    Histone H3.1(Phospho-Ser10) Antibody

    Lian-Qing Sun 1, Ying-Ying Chen 1, Xuan Wang, Xiao-Jin Li, Bing Xue, Ling Qu, Ting-Ting Zhang,Yi-Ming Mu, Ju-Ming Lu,The protective effect of Alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose, Biochemical Pharmacology 84 (2012) 961–973

    11184

    Histone H3.1(Phospho-Ser10) Antibody

    Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
    (2014), http://dx.doi.org/10.1016/j.molcel.2013.11.001

    11184

     Histone H3.1(Phospho-Ser10) Antibody

    Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.

    11192

     HDAC4 (Phospho-Ser632) Antibody

     S Lim, M Luo, M Koh, et al. (2007) Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ß-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.Molecular and Cellular Biology, 27(11):4105-4120.

    11193

    HDAC5 (Phospho-Ser498) Antibody

    J Bossuyt, K Helmstadter, X Wu, et al. (2008) Ca2+/Calmodulin-Dependent Protein Kinase II {delta} and Protein Kinase D Overexpression Reinforce. Circulation Research, 102(6):695-702.

    11193

    HDAC5 (Phospho-Ser498) Antibody

     Pang J, Yan C, Natarajan K, et al. (2008) GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):892-8. 

    11193

    HDAC5 (Phospho-Ser498) Antibody

     S Lim, M Luo, M Koh, et al. (2007) Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ß-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.Molecular and Cellular Biology, 27(11):4105-4120.

    11193

    HDAC5 (Phospho-Ser498) Antibody

    Weiye Wang, Chang Hoon Ha, Bong Sook Jhun,et al(2010)Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood, 115( 14), 2971-2979.

    11193

    HDAC5 (Phospho-Ser498) Antibody

     Sheng Xia,Xiaogang Li,Teri Johnson,et al (2010)Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.Development, 137, 1075-1084.

    11201

    Paxillin (Phospho-Tyr31) Antibody

    Zhi Huang, Da-Peng Yan, Bao-Xue Ge,et al. (2008)JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.Cellular Signalling ,20: 2002-2012

    11202

    Ezrin (Phospho-Thr567) Antibody 

    Yazhou Cui, Tianliang Li, Denglu Zhang,et al.(2010)Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma. Cancer Investigation 28(3) 242-247

    11215

    FAK (Phospho-Tyr397) Antibody

     Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229

    11215

    FAK(Phospho-Tyr397) Antibody

    JUNSHAN RUAN1,3*, LEI ZHANG1*, LINGGENG YAN1, YUPING LIU1, ZHIQIANG YUE1, LI CHEN1,AI-YUN WANG1, WENXING CHEN1, SHIZHONG ZHENG1, SHAOMING WANG3 and YIN LU, Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells, MOLECULAR MEDICINE REPORTS 6: 232-238, 2012

    11216

    Pyk2(Phospho-Tyr402) Antibody

    Mineko Tomomura, Hiroya Hasegawa, Naoto Suda, Hiroshi Sakagami, et al. (2012) Serum Calcium-decreasing Factor, Caldecrin, Inhibits Receptor Activator of NF- B Ligand (RANKL)-mediated Ca2  Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of Src Signaling Pathway. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 22, pp. 17963–17974

    11219

    β-Catenin (Phospho-Ser37) Antibody

    Yuhua Li , Yinbo Niu , Huanjie Wu,et al.(2010) PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo. Cancer Science,100(12) 2451 - 2458

    11220

    EGFR(Phospho-Tyr1172) Antibody

    Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.

    11220

    EGFR(Phospho-Tyr1172) Antibody

    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.

    11221

    mTOR(Phospho-Ser2448) Antibody

    Macias M, Blazejczyk M, Kazmierska P, Caban B, Skalecka A, et al. (2013) Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment. PLoS ONE 8(5): e64455. doi:10.1371/journal.pone.0064455

    11221

    mTOR(Phospho-Ser2448) Antibody

    Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881

    11223

     4E-BP1 (Phospho-Thr45) Antibody

    Jiumei Cao,Limin Gong, Dong-chuan Guo,et al.(2010)Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/–  mice. Human Molecular Genetics, doi:10.1093/hmg/ddq066

    11232

    S6 Ribosomal Protein(Phospho-Ser235) Antibody

    Zeynep Nesli ERDEM.(2011) FGFR4 mediated Growth and Survival signals in Colon Carcinoma cells.

    11240

    Phospho-c-Kit (Tyr721) antibody

    Xiao-ning Gao, Ji Lin, Li Gao, et al (2011)MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. Leukemia Research, Volume 35, Issue 9, September 2011, Pages 1226-1232

    11244

    CDC2(Phospho-Tyr15) Antibody

    Qi Yao, Hui Li, Bing-Qian Liu, Xin-Yun Huang, et al. (2013) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 31, pp. 27342–27349

    11244

    CDC2(Phospho-Tyr15) Antibody

    Philip M. KUBARA, Sophie KERN´EIS-GOLSTEYN, Aur´elie STUD´ENY, Brittany B. LANSER, et al. (2012) Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. Biochem. J. 446:373–381

    11245

    p44/42 MAP Kinase (Phospho-Thr202) Antibody

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,

    11246

    P-ERK

    Jin-Hang Gao, Shi-Lei Wen, Wen-Juan Yang, Yao-Yao Lu, et al. (2013) Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis. PLoS ONE 8(7): e69309. doi:10.1371/journal.pone.0069309

    11249

    SAPK/JNK (Phospho-Thr183) Antibody

    Anastasia F. Thévenina, Chati L. Zonya, Brian J. Bahnsona , et al (2010)Activation by phosphorylation and purification of human c-Jun N-terminal Kinase (JNK) isoforms in milligram amounts.  Protein Expression and Purification, 75( 2) ,138-146

    11249

    SAPK/JNK(Phospho-Thr183) Antibody

    Peng Jiao • Yun-Sheng Zhou • Juan-Xia Yang • Ya-Li Zhao • Qiang-Qiang Liu • Chuang Yuan • Feng-Ze Wang, MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death,Mol Cell Biochem DOI 10.1007/s11010-013-1737-0

    11252

    P38 MAPK(Phospho-Thr180) Antibody

    Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774

    11253

    P38 MAPK(Phospho-Tyr182) Antibody

    RS Chen, YM Song, et al.(2008) Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway . Oncogene, 28, 599–609

    11253

    P38 MAPK(Phospho-Tyr182) Antibody

    Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774

    11254

    p70 S6 Kinase (Phospho-Thr421) Antibody

    X Tang, X Zhou, K Zhou,et al.( 2009) Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein.Acta Pharmacologica Sinica. 30 (5): 605–616

    11260

    NFκB-p65((phospho-Ser311) Antibody

    Dan-Dan Shi†, Hu Shi†, Dan Lu, Rui Li, Yu Zhang and Jun Zhang, NDR1/STK38 potentiates NF-kB activation by its kinase activity, Cell Biochem Funct 2012; 30: 664–670

    11268

    Histone H2A.X(Phospho-Ser139) Antibody

    Xiukun Cui a,1, Jing Zhang a,b,1, Rong Du c,1, Lei Wang a, Stephen Archacki d, Yuexuan Zhang a, Mingxiong Yuan a, Tie Ke a, Hui Li a, Duanzhuo Li a, Chang Li a, David Wan-Cheng Li e, Zhaohui Tang a,Zhan Yin, Mugen Liu, HSF4 is involved in DNA damage repair through regulation of Rad51,Biochimica et Biophysica Acta 1822 (2012) 1308–1315

    11280

    PKR(Phospho-Thr446) Antibody

    Suzette Laing , Guohui Wang , Tamara Briazova ,et al (2010)Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues. Amerian Journal of  Physiol Cell Physiol (June 16, 2010). doi:10.1152/ajpcell.00529.2009

    11284

    p70 S6 Kinase (Phospho-Ser424) Antibody

    Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959

    11290

    PKR(Phospho-Thr451) Antibody

    Suzette Laing , Guohui Wang , Tamara Briazova ,et al (2010)Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues. Amerian Journal of  Physiol Cell Physiol (June 16, 2010). doi:10.1152/ajpcell.00529.2009

    11294

    MEK1(Phospho-Thr291) Antibody

    Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106

    11294

    MEK1(Phospho-Thr291) Antibody

    Akira Ikari, Kosuke Atomi, Keishi Kinjo, Yohei Sasaki, Junko Sugatani (2010) Magnesium deprivation inhibits a MEK–ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sciences. 86:766–773

    11296

    PKCd(Phospho-Ser645) Antibody

    M. Uenoyama, S. Ogata, K. Nakanishi, F. Kanazawa, et al.(2010) Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats. Acta Physiol. 198:431–440

    11300

    CREB(Phospho-Ser142) Antibody

    Tomasz Boczek • Anna Kozaczuk • Bozena Ferenc •Michalina Kosiorek • Slawomir Pikula •Ludmila Zylinska, Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin, Mol Cell Biochem (2012) 360:89–102

    11301

    GSK3β(Phospho-Tyr216) Antibody

     Hirakawa Hiroshi,Nakayama Toshiyuki, Shibata Kenichiro et al (2009) Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development. Oncology Reports, 22(3), 481-485

    11301

    GSK3b(Phospho-Tyr216) Antibody

    Song Chen & Ai-ran Liu & Feng-mao An & Wen-bing Yao & Xiang-dong Gao, Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4, AGE (2012) 34:1211–1224

    11321

    Smad1(Phospho-Ser465) Antibody

    Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.

    11322

    Smad2(Phospho-Ser467) Antibody

    Xing-Yi Zhang, Bao-Rong Shen, Yu-Cheng Zhang, Xue-Jiao Wan, Qing-Ping Yao,et al (2013) Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice. PLoS ONE. 8(3): e59002. doi:10.1371/journal.pone.0059002

    11323

    Smad2(Phospho-Thr220) Antibody

    Xing-Yi Zhang, Bao-Rong Shen, Yu-Cheng Zhang, Xue-Jiao Wan, Qing-Ping Yao,et al (2013) Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice. PLoS ONE. 8(3): e59002. doi:10.1371/journal.pone.0059002

    11325

    Smad3(Phospho-Ser425) Antibody

    Mitsuko Moriguchi, Marie Yamada, Yasuo Miake and Mayu Koshika. (2012) Immunolocalization of Axin2 and p-Smad3 in Developing Rat Molar Germ.Journal of Hard Tissue Biology. 21[2] p.113 - 120

    11327

    TrkB(Phospho-Tyr515) Antibody

    YeeWen Candace Wu, Rachel A. Hill, Maren Klug, Maarten van den Buuse (2012) Sex-specific and region-specific changes in BDNF–TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice.  Brain Research.Volume 1452, Pages 10–17

    11327

    TrkB(Phospho-Tyr515) Antibody

    Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272

    11328

    TrkB(Phospho-Tyr705) Antibody

    Rachel A. Hill, Maarten van den Buuse (2011) Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. Brain Research, Volume 1384, Pages 51-60

    11328

    TrkB(Phospho-Tyr705) Antibody

    Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos, Maarten van den Buuse. (2013) Sex-denpendent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steriod hormones. Neurochem. 126: 389--399

    11328

    TrkB(Phospho-Tyr705) Antibody

    R. A. Hill , Y. W. C. Wu, P. Kwek and M. van den Buuse,Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice,Journal of Neuroendocrinology, 2012, 24, 774–788

    11330

    a-catenin(Phospho-Ser641) Antibody

    Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell 36(4):547-59 (Selected as the feature article by Mol Cell and highlighted in Cell and M.D. Anderson News Release), 11/2009. PMCID: PMC2784926.

    11456

     PKM2(phospho-Ser37) Antibody

    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.

    11507

    cofilin1/cofilin2(phospho-Tyr88) Antibody

    Xiaodong Li, Qiang Ke, Yanshu Li, Funan Liu, Ge Zhu, Feng Li ,DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1 ,The International Journal of Biochemistry& Cell Biology 42 (2010) 70–79 Contents lists

    11517

    HDAC4/HDAC5/HDAC9(phospho-Ser246/259/220) Antibody

    Weiye Wang.(2010) A Novel Role of HDAC5 in Flow-Induced Gene Expression. Department of Pharmacology and Physiology School of Medicine and Dentistry University of Rochester Rochester

    11545

    FAK (phospho-Tyr576/Tyr577) Antibody

     Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229

    11545

    FAK(phospho-Tyr576/Tyr577) Antibody

    Jun-shan RUAN, Yu-ping LIU1, Lei ZHANG1, Ling-geng YAN, et al. (2012) Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacologica Sinica. 33: 1325–1331

    11550

    MDM2(phospho-Ser166) Antibody

    Hetian Lei, Gisela Velez, and Andrius Kazlauskas. (2010) Pathological Signaling via Platelet-Derived Growth Factor Receptor Involves Chronic Activation of Akt and Suppression of p53. MOLECULAR AND CELLULAR BIOLOGY, May 2011, p. 1788–1799

    11552

    Sufu(Phospho-Ser342) Antibody

    Yan Chen, Shen Yue, Lu Xie, Xiao-hong Pu,Tian Jin and Steven Y. Cheng, Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 15, pp. 13502–13511, April 15, 2011

    11553

    Cdc25B(Phospho-Ser149) Antibody

    Jianying Xiao, Chao Liu, Junjie Hou, Cheng Cui,et al. (2011) Ser149 Is Another Potential PKA Phosphorylation Target of Cdc25B in G2/M Transition of Fertilized Mouse Eggs. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 12, pp. 10356–10366,

    11553

    Cdc25B(Phospho-Ser149) Antibody

    XIAO Jian-Ying,LIU Chao,SUN Xiao-Han,YU Bing-Zhi,CDC25B Subcellular Localization Influences One-cell Stage Mouse Embryos[J]  Chinese Journal of Biochemistry and Molecular Biol, 2013,V29(1): 33-41

    11554

    IL-10R subunit a(Phospho-Ser319/323) Antibody

    Jiang H, Lu Y, Yuan L, Liu J (2011) Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase. PLoS ONE 6(11): e27464. doi:10.1371/journal.pone.0027464

    11578

    Niban(Phospho-Ser602) Antibody

    Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560

    11578

    Niban(Phospho-Ser602) Antibody

    Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.

    11581

    P38 MAPK(Phospho-Thr180/Tyr182) antibody

    Jia-Ping Ruan, M.D., Hong-Xing Zhang, M.D., Xian-Fu Lu, M.D., Yue-Peng Liu, M.D., et al.(2010) EphrinBs/EphBs Signaling Is Involved in Modulation of Spinal Nociceptive Processing through a Mitogen-activated Protein Kinases-dependent Mechanism. Anesthesiology. 112:1234-49

    11581

    P38 MAPK(Phospho-Thr180/Tyr182) antibody

    Peter Schubert, Danielle Coupland, Brankica Culibrk, Raymond P. Goodrich, et al. (2013) Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. TRANSFUSION. Volume **, ** **

    11586

    Bub3 (Phospho-Tyr207) Antibody

    Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
    (2014), http://dx.doi.org/10.1016/j.molcel.2013.11.001

    11889

    phospho‐ERK1/2

    Yinbo Niu, Yuhua Li, Haitao Huang, Xianghe Kong, et al. (2011) Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway. Phytother. Res. 25: 1700–1706

    20184

    p53(Ab-9) Antibody

    Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128

    21001

    c-Jun (Ab-63) Antibody

    kira Ikari,Hayato Sawada, et al. (2008)Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A  Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.

    21002

    GSK3β (Ab-9) Antibody

    Cong REN, Jia-Mou LI, Xin LIN (2010)LIPUS Enhance Elongation of Neurites in Rat Cortical Neurons through Inhibition of GSK-3β. Biomedical and Environmental Sciences, Volume 23, Issue 3, Pages 244-249

    21002

    GSK3b(Ab-9) Antibody

    Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607

    21002

    GSK3b(Ab-9) Antibody

    Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17

    21002

    GSK3b(Ab-9) Antibody

    Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015

    21002

    GSK3b(Ab-9) Antibody

    Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957

    21002

    GSK3b(Ab-9) Antibody

    Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83

    21003

    c-Jun (Ab-73) Antibody

    kira Ikari,Hayato Sawada, et al. (2008) Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A  Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.

    21005

    PDK1(Ab-241) Antibody

    Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959

    21005

    PDK1(Ab-241) Antibody

    Yongheng Cao1,2,11, Masanori Nakata3, Shiki Okamoto4, Eisuke Takano3, Toshihiko Yada3, Yasuhiko Minokoshi4, Yukio Hirata5, Kazunori Nakajima5, Kristy Iskandar1, Yoshitake Hayashi1, Wataru Ogawa6, Gregory S. Barsh7, Hiroshi Hosoda8, Kenji Kangawa8, Hiroshi Itoh9, Tetsuo Noda10, Masato Kasuga7,11, Jun Nakae, PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure, April 2011 | Volume 6 | Issue 4 | e18324

    21006

    Raf1(Ab-259) Antibody

    Zhi-Xin Qiu, Lei Wang,Juan Han, Dan Liu, et al.(2012) Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer. Cancer Sci. vol. 103 no. 10 pp. 1774–1779

    21010

    NFkB-p65(Ab-254) Antibody

    Naina Shah, Montserrat Montes de Oca, Maria Jover-Cobos, Ken-ichi Tanamoto, et al.(2013) Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure. LIVER TRANSPLANTATION 19:751–761

    21011

    NFκB-p65(Ab-276) Antibody

    S. Clockaerts, Y.M. Bastiaansen-Jenniskens, C. Feijt, et al (2011) Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage. Osteoarthritis and Cartilage, Volume 19, Issue 7, July 2011, Pages 895-902

    21011

    NFkB-p65(Ab-276) Antibody

    Gerben M. van Buul, Wendy L.M. Koevoet, Nicole Kops, P. Koen Bos, et al.(2011) Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes. Am J Sports Med. 39: 2362-2370

    21014

    NFkB-p65(Ab-536) Antibody

    Naina Shah, Dipok Dhar, Fatma El Zahraa Mohammed1, Abeba Habtesion, et al. (2012) Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Journal of Hepatology. vol. 56:1047–1053

    21021

    c-Jun (Ab-91) Antibody

    kira Ikari,Hayato Sawada, et al. (2008) Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A  Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.

    21022

    c-Jun(Ab-93) Antibody

    Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215

    21034

    Myc(Ab-58) Antibody

    S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113

    21035

    Myc(Ab-358) Antibody

    S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113

    21036

    Myc(Ab-373) Antibody

    S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113

    21044

    STAT1(Ab-701) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21045

    STAT3 (Ab-705) Antibody

    Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro, et al (2010)Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition. Journal of Investigative Dermatology 130, 2760-2767

    21045

    STAT3 (Ab-705) Antibody

    Emilio García-Prieto, Adrián González-López,, Sandra Cabrera, et al (2010)Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. PloS one, 5(10): e13242.

    21045

    STAT3(Ab-705) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21046

    STAT3(Ab-727) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21046

    STAT3(Ab-727) Antibody

    Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988

    21047

    STAT4(Ab-693) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21049

    STAT5a(Ab-780) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21051

    STAT6(Ab-645) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21052

    CREB (Ab-133) Antibody

    Tomasz Boczek, Anna Kozaczuk, Bozena Ferenc, Michalina Kosiorek and Slawomir Pikula, et al.Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin.Molecular and Cellular Biochemistry, 12 September 2011

    21053

     ATF4 (Ab-245) Antibody

    Hong-Li Wu, Yu-Hua Li, Yan-Hua Lin, et al. (2008)  Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction.Cardiovasc Res, 81:148-158

    21054

    Akt (Ab-473) Antibody

    Young Yil Bahk, Ick-Hyun Cho, Tong Soo Kim. A Cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts.Biochemical and Biophysical Research Communications, 377:1199–1204.

    21054

    Akt (Ab-473) Antibody

    Jing Zhang, Osamu Yamada, Yoshihisa Matsushita, ect.(2009) Transactivation of human osteopontin promoter by human T-cell leukemia virus type 1-encoded Tax proteinLeukemia Research in press.

    21054

    Akt (Ab-473) Antibody

    Seyoon Kim, Yong Zu Lee, Yu Sam Kim,et al (2008)A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. Proteomics, 8 (15), 3082 - 3093

    21054

    Akt (Ab-473) Antibody

    Hyun Seung Ban, Masaharu Uno, Hiroyuki Nakamura, et al (2010)Suppression of hypoxia-induced HIF-1 [alpha] accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer letters ,296,( 1) 17-26

    21054

    Akt (Ab-473) Antibody

    Yingjia Guo, Tong Yang, Jun Lu, et al (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences, Volume 88, Issues 13-14, Pages 598-605

    21054

    Akt(Ab-473) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21054

    Akt(Ab-473) Antibody

    Ze-yang Ding, Guan-nan Jin, Hui-fang Liang, Wei Wang, et al. (2013) Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cellular Signalling. 25:1981–1992

    21054

    Akt(Ab-473) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    21054

    Akt(Ab-473) Antibody

    Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428

    21054

    Akt(Ab-473) Antibody

    Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988

    21054

    Akt(Ab-473) Antibody

    Massimo Nabissi, Maria Beatrice Morelli1, Consuelo Amantini, Valerio Farfariello1, et al. (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis vol.31 no.5 pp.794–803

    21054

    Akt(Ab-473) Antibody

    Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957

    21054

    Akt(Ab-473) Antibody

    Hu Ma, Quan Yao, An-Mei Zhang, Sheng Lin, Xin-Xin Wang, Lei Wu, Jian-Guo Sun,and Zheng-Tang Chen(2011)The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model. Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556

    21054

    Anti-STAT3

    Heng-Fei Luan1*, Zhi-Bin Zhao1*, Qi-Hong Zhao2, Pin Zhu1, Ming-Yu Xiu1 and Yong Ji, Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway

    21054

    Akt(Ab-473) Antibody

    Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69

    21054

    Akt(Ab-473) Antibody

    Song Chen, Hedeel Guy Evans and David R.,Evans, FAM129B/MINERVA, a Novel Adherens Junction-associated Protein, Suppresses Apoptosis in HeLa Cells, J. Biol. Chem. 2011, 286:10201-10209.

    21054

    Akt(Ab-473) Antibody

    Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326

    21055

    Akt (Ab-308) Antibody

    Nabissi Massimo,Morelli Maria Beatrice,Amantini Consuelo, et al (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis. 0: bgq019v1-bgq019

    21055

    Akt(Ab-308) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21055

    Akt(Ab-308) Antibody

    Hyun Seung Ban, Masaharu Uno, Hiroyuki Nakamura. (2010) Suppression of hypoxia-induced HIF-1a accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer Letters. 296:17–26

    21055

    Akt(Ab-308) Antibody

    Yingjia Guo, Tong Yang, Jun Lu, Shengfu Li, et al. (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 88:598–605

    21055

    Akt(Ab-308) Antibody

    Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83

    21055

    Akt(Ab-308) Antibody

    Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69

    21057

    PTEN(Ab-370) Antibody

    Zhi Li & Gong Xiang Liu & Yu Lan Liu & Xi Chen & Xiao Li Huang & Hua Tian Gan,  Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer, Int J Colorectal Dis (2013) 28:1107–1115

    21059

    BCL-2(Ab-56) Antibody

    Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–139

    21060

    BCL-2(Ab-70) Antibody

    Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–139

    21064

    BAD(Ab-155) Antibody

    Yi Huang • Dan Liu • Bojiang Chen • Jing Zeng • Lei Wang • Shangfu Zhang • Xianming Mo • Weimin Li, Loss of Bad expression confers poor prognosis in non-small cell lung cancer,Med Oncol (2012) 29:1648–1655

    21065

    Estrogen Receptor-α (Ab-104) Antibody

    Yamaguchi, J Zhu, T Yu, et al. (2007)  Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.

    21066

    Estrogen Receptor-α (Ab-106) Antibody

    Yamaguchi, J Zhu, T Yu, et al. (2007)Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.

    21070

    HER2(Ab-877) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21071

    HER2(Ab-1221/1222) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21072

    HER2(Ab-1248) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant
    Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21072

    HER2(Ab-1248) Antibody

    Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83

    21073

    EGFR(Ab-1070) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21074

    EGFR(Ab-1092) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21079

    VEGFR2(Ab-951) Antibody

    Qi Zhao, TakakoYokozawab, NorikoYamabeb, et al (2010) Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. Journal of EthnopharmacologyArticle in Press

    21079

    VEGFR2(Ab-951) Antibody

    Qi Zhao, Takako Yokozawa, Koichi Tsuneyama, Ken Tanaka and Takeshi Miyata, et al.Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.Chinese Medicine, 2011, Volume 6, Number 1, 33

    21079

    VEGFR2(Ab-951) Antibody

    Qi Zhao, Yimin Niu, Kinzo Matsumoto1, Koichi Tsuneyama, et al. (2012) Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complementary and Alternative Medicine. 12:188

    21080

    IGF-1R(Ab-1161) Antibody

    Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377

    21080

    IGF-1R(Ab-1161) Antibody

    TAKETSUGU YAMAMOTO, TAKASHI OSHIMA, KAZUE YOSHIHARA, TEPPEI NISHI, HIROMASA ARAI,KENJI INUI, TAKESHI KANEKO, AKINORI NOZAWA, HIROYUKI ADACHI, YASUSHI RINO, MUNETAKA MASUDA and TOSHIO IMADA(2012)Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer,EXPERIMENTAL AND THERAPEUTIC MEDICINE 3: 797-802, 2012

    21081

    IGF-1R(Ab-1165/1166) Antibody

    Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,

    21081

    IGF-1R(Ab-1165/1166) Antibody

    Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377

    21083

    p53(Ab-6) Antibody

    Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560

    21083

    p53(Ab-6) Antibody

    Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128

    21083

    p53(Ab-6) Antibody

    Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.

    21085

    p53(Ab-15) Antibody

    Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128

    21086

    p53(Ab-18) Antibody

    Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128

    21090

    p53(Ab-46) Antibody

    Lei Zhang, Junshan Ruan, Linggeng Yan, Weidong Li, et al.(2012) Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells. Molecules. 17:3736-3750

    21103

    β-Catenin(Ab-41/45) Antibody

    Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research,  9, 22–29

    21103

    β-Catenin(Ab-41/45) Antibody

    Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,Volume 42, Issue 5, May 2010, Pages 762–770

    21106

    ICAM-1(Ab-512) Antibody

    Oualid Sbai, Adlane Ould-Yahoui, Lotfi Ferhat,et al.(2009)Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes.Glia, 58( 3),  344 – 366

    21106

    ICAM-1(Ab-512) Antibody

    Xi-Jin Wang, Shi Zhang, Zhi-Qiang Yan, et al(2011) Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radical Biology and Medicine, Volume 50, Issue 9, Pages 1094-1106

    21109

    Rb(Ab-807) Antibody

    Hui Xu1, Yaping Yan, Mark S. Williams, Gregory B. Carey, et al. (2010) MS4a4B, a CD20 Homologue in T Cells, Inhibits T Cell Propagation by Modulation of Cell Cycle. PLoS ONE 5(11): e13780. doi:10.1371/journal.pone.0013780

    21110

    Rb(Ab-780)Antibody

    Xueting Cai, Tingmei Ye, Chao Liu, et al (2011) Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicology in Vitro, Volume 25, Issue 7,  Pages 1385-1391

    21110

    Rb(Ab-780) Antibody

    Heidi Braumuller, ThomasWieder, Ellen Brenner, Sonja Aßmann, et al. (2013) T-helper-1-cell cytokines drive cancer into senescence. NATURE.494:361-366

    21111

    CDK2 (Ab-160) Antibody

    Song Chen, Hedeel Guy Evans and David R.Evans (2010)FAM129B/minerva, a novel adherens junction associated protein suppresses apoptosis in hela cells. Journal of Biological Chemistry, 2010 - ASBMB

    21111

    CDK2(Ab-160) Antibody

    Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428

    21119

    JAK1 (Ab-1022) Antibody

    Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164

    21125

    ASK1 (Ab-83) Antibody

    Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588

    21127

    LIMK1 (Ab-508) Antibody

    Li, X., Ke, Q., Li, Y., Liu, F., Zhu, G., & Li, F., et al. (2008)DGCR6L, A Novel PAK4 Interaction Protein, Regulates PAK4-mediated migration of Human Gastric Cancer Cell via LIMK1 International Journal of Biochemistry and Cell Biology, 42: 70–79

    21129

    PLCγ1 (Ab-783) Antibody

     Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu ,et al(2010)Inhibition of vascular smooth muscle cell proliferation of vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: Pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology and Medicine, Article in Press, Accepted Manuscript

    21129

    PLCg1(Ab-783) Antibody

    Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607

    21130

    AMPKa1(Ab-487) Antibody

    Yan-Na Huang, Jian-Hua Qi, Lan Xiang , Yi-Zhen Wang(2012)Construction of adiponectin-encoding plasmid DNA and overexpression in mice
    in vivo.Gene 502 (2012) 87–93

    21134

    ASK1 (Ab-966) Antibody

    Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588

    21137

    Histone H3.1(Ab-10) Antibody

    Guo-Dong Li , Xi Zhang , Rong Li , et al. (2008)CHP2 activates the calcineurin/NFAT signaling pathway and enhances the oncogenic potential of HEK293 cells  JBC, 283 (47): 32660–32668

    21137

    Histone H3.1(Ab-10) Antibody

    Chao Yu, Ting Shan, Aiwen Feng, et al(2011) Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway.Fitoterapia, Volume 82, Issue 4, June 2011, Pages 709-715

    21137

    Histone H3.1(Ab-10) Antibody

    MIN HUANG, JING ZHOU, LIQING BI, QIAN ZHANG, SUMING ZHOU (2012) Anti-Toll-like receptor 2 antibody, T2.1, reduces tumor necrosis factor α and interleukin-6 release and inhibits nuclear factor κB expression in bacterial lipoprotein stimulated THP-1 cells.Centr Eur J Immunol. 37 (1): 6-10

    21137

    Histone H3.1(Ab-10) Antibody

    Chen S, Evans HG, Evans DR (2012) FLASH Knockdown Sensitizes Cells To Fas-Mediated Apoptosis via Down-Regulation of the Anti-Apoptotic Proteins,MCL-1 and Cflip Short. PLoS ONE 7(3): e32971. doi:10.1371/journal.pone.0032971

    21137

    Histone H3.1(Ab-10) Antibody

    Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, et al.(2013) Cancer Cells Phosphorylation of Both Proteins in Breast on Interacting with c-Fos and Hepatitis B X-interacting Protein Depends The Nuclear Import of Oncoprotein. J. Biol. Chem.10.1074/jbc.M113.458638

    21137

    Histone H3.1(Ab-10) Antibody

    Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428

    21137

    Histone H3.1(Ab-10) Antibody

    C.Y. MA, C.P. ZHANG, L.P. ZHONG, H.Y. PAN1, et al. (2011) Decreased expression of profilin 2 in oral squamous cell carcinoma and its clinicopathological implications. ONCOLOGY REPORTS 26: 813-823

    21137

    Histone H3.1(Ab-10) Antibody

    Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, et al. (2011) Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway. Journal of Cellular Biochemistry 112:2837–2849

    21137

    Histone H3.1(Ab-10) Antibody

    Zenglin Liao†, Jiajia Dong†, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen, Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway, Liao et al. Respiratory Research 2012, 13:110

    21138

    FKHR(Ab-256) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    21142

    HDAC5 (Ab-498) Antibody

    Pang J, Yan C, Natarajan K, et al. (2008) GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):892-8. 

    21142

    HDAC5 (Ab-498) Antibody

    Weiye Wang, Chang Hoon Ha, Bong Sook Jhun,et al(2010)Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood, 115( 14), 2971-2979.

    21144

    HSP27(Ab-15) Antibody

    Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance
    to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-13

    21147

    ATM(Ab-1981) Antibody

    Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J. Lamont and Atsuo Amano, Identification of Signaling Pathways Mediating Cell Cycle Arrest and Apoptosis Induced by Porphyromonas gingivalis in Human Trophoblasts, Infect. Immun. 2012, 80(8):2847. DOI: 10.1128/IAI.00258-12.

    21149

    p21Cip1(Ab-145) Antibody

    Masahiko Kanehira, Toshiaki Kikuchi, Shinya Ohkouchi, Taizou Shibahara, et al. (2012) Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells.PLoS ONE 7(2): e32185. doi:10.1371/journal.pone.0032185

    21150

    p27Kip1 (Ab-10)Antibody

    Fan Yang, Yu-Ping Xu , et al(2009).Cloning and Characterization of a Novel Intracellular Protein p48.2 that Negatively Regulates Cell Cycle Progression.The International Journal of Biochemistry & Cell Biology, 41 (11): 2240–2250

    21160

    PAK1(Ab-212) Antibody

    Bingyuan Wang1†, Wei Ma1,3†, Xiaoling Xu1,2, Chao Wang1, Yubo Zhu1, Na An1, Lei An1, Zhonghong Wu and Jianhui Tian1 , Phosphorylation of histone H3 on Ser10 by auto-phosphorylated PAK1 is not essential for chromatin condensation and meiotic progression in porcine oocytes, Wang et al. Journal of Animal Science and Biotechnology 2013, 4:13

    21163

    cdc25A(Ab-76) Antibody

    XIAO Jian-Ying,LIU Chao,SUN Xiao-Han,YU Bing-Zhi,CDC25B Subcellular Localization Influences One-cell Stage Mouse Embryos[J]  Chinese Journal of Biochemistry and Molecular Biol, 2013,V29(1): 33-41

    21164

    cofilin(Ab-3) Antibody

    Lijun Zhang, Jun Luo, Ping Wan, Jing Wu, et al. (2011) Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development. 138:455-464

    21166

    IRS-1 (Ab-312) Antibody

    Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038

    21168

    Src (Ab-529) Antibody

    Yanhua Zheng, Yan Xia, Xiang Gao, Zhimin Lu, et al. (2009) Molecular Cell,35:11–25FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST.

    21170

    Anti-eNOS antibody

    Jian Jiao, Hong Wang, Wei Lou, et al (2011) Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cells. Experimental Cell Research, Volume 317, Issue 17,  Pages 2548-2553

    21177

    STAT1(Ab-727) Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    21187

    FLT3 (Ab-591) Antibody

    Nana Ninagawa, Rumi Murakami, Eri Isobe,et al (2011) Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits. Differentiation, Volume 82, Issue 3, Pages 153-164

    21193

    EGFR(Ab-678) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21194

    EGFR(Ab-693) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21196

    Ephrin-B2(Ab-330) Antibody

    Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957

    21209

    Pyk2(Ab-402) Antibody

    Rui-Fang Liu a,b, Xiao Xu a,b, Jian Huang a,b, Qian-Lan Fei b, Fei Chen b, Yan-Dong Li b, Ze-Guang Han, Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2,Cancer Letters 329 (2013) 164–173

    21211

    β-Catenin (Ab-33) Antibody

    Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research,  9, 22–29

    21211

    β-Catenin (Ab-33) Antibody

    Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,In press

    21211

    β-Catenin (Ab-33) Antibody

    Lei Hana, Yang Yanga, Xiao Yue, et al (2010)Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of [beta]-catenin-mediated transcription. Brain Research, 1366, 9-17

    21212

    β-Catenin (Ab-37) Antibody

    Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research,  9, 22–29

    21212

    β-Catenin (Ab-37) Antibody

    Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,In press

    21213

    EGFR(Ab-1172) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21213

    EGFR(Ab-1172) Antibody

    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.

    21220

    Met (Ab-1234) Antibody

    Na Li, Hanjiang Fu, Yi Tie, et al. (2008) miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells.Cancer Letters, 275(1):44-53

    21220

    Met(Ab-1234) Antibody

    Luo W, Huang B, Li Z, Li H, Sun L, et al. (2013) MicroRNA-449a Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Migration and Invasion by Targeting c-Met. PLoS ONE 8(5): e64759

    21221

    EGFR(Ab-1197) Antibody

    Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895

    21223

    IRS-1(Ab-636) Antibody

    Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038

    21224

    IRS-1(Ab-639) Antibody

    Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038

    21228

    IRS-1 (Ab-307) Antibody

    Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038

    21232

    c-Kit(Ab-721) Antibody

    Shinka Miyamoto, Nanako Kawaguchi, Georgina M. Ellison, Rumiko Matsuoka, et al. (2010) Characterization of Long-Term Cultured c-kit+ Cardiac Stem Cells Derived From Adult Rat Hearts. STEM CELLS AND DEVELOPMENT. Volume 19, Number 1

    21234

    BRCA1(Ab-1423) Antibody

    Bo Xiong, Sen Li, Jun-Shu Ai, et al. (2008) BRCA1 Is Required for Meiotic Spindle Assembly and Spindle Assembly Checkpoint Activation in Mouse Oocytes. .Biol Reprod, 79, 718–726

    21236

    CDC2(Ab-15) Antibody

    Qi Yao, Hui Li, Bing-Qian Liu, Xin-Yun Huang, et al. (2013) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 31, pp. 27342–27349

    21236

    CDC2(Ab-15) Antibody

    Philip M. KUBARA, Sophie KERN´EIS-GOLSTEYN, Aur´elie STUD´ENY, Brittany B. LANSER, et al. (2012) Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. Biochem. J. 446:373–381

    21239

    HSP27(Ab-78) Antibody

    Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-13

    21240

    HSP27(Ab-82) Antibody

    Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-13

    21241

    SAPK/JNK(Ab-183) Antibody

    Anastasia F. Thévenin, Chati L. Zony, Brian J. Bahnson, Roberta F. Colman.(2011) Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. Protein Expression and Purification. 75: 138–146

    21245

    p38 MAPK (Ab-182) Antibody

    Yi-Wen Gu, Dian-San Su, Jie Tian et al. (2008)Neuroscience Letters, 431(2):129-34. Attenuating phosphorylation of p38 MAPK in the activated microglia: A new mechanism for intrathecal lidocaine reversing tactile allodynia  following chronic constriction injury in rats.

    21245

    p38 MAPK (Ab-182) Antibody

    Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774

    21249

    Tau(Ab-212) Antibody

    Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957

    21257

    MARCKS (Ab-162) Antibody

    Maria C. Olianas, Simona Dedoni, Pierluigi Onali (2011) Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells. Neuropharmacology, Volume 60, Issues 7-8, Pages 1326-1336

    21260

    Histone H2A.X (Ab-139) Antibody

    Jennifer S. Dickey,Christophe E. Redon,Asako J. Nakamura, et al (2009) H2AX: functional roles and potential applications.Chromosoma 118:683–692

    21260

    Histone H2A.X(Ab-139) Antibody

     Xiaohan Li, Takeshi Nishida, Akira Noguchi, et al (2010) Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma, Journal of Cancer Research and Clinical Oncology, 136( 10), 1573-1583

    21260

    Histone H2A.X(Ab-139) Antibody

    Xiao-han Li, Keiji Kikuchi, Yang Zheng, et al (2011) Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. Oral Oncology, Volume 47, Issue 3, March 2011, Pages 217-223

    21260

    Histone H2A.X(Ab-139) Antibody

    Teng Li, Jing Hu, Gong-Hao He, Yun Li, Chu-Chao Zhu, et al (2012) Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes. Biochimica et Biophysica Acta. 1822:301–313

    21260

    Histone H2A.X(Ab-139) Antibody

    Yan Qing • Yanfang Liang • Qingqing Du •Pan Fan • Hangong Xu • Yiping Xu • Nian Shi,Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-jB and MAPKs signaling pathways,Arch Toxicol (2013) 87:1273–1285

    21264

    Cortactin(Ab-466) Antibody

    Nobuo Terada, Nobuhiko Ohno, Sei Saitoh, et al (2009)  Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells.Cell Tissue Res: 337:91–102

    21271

    eIF2α (Ab-51) Antibody

    Hong-Li Wu, Yu-Hua Li, Yan-Hua Lin, et al. (2008)  Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction.Cardiovasc Res, 81:148-158

    21274

    Integrin b3(Ab-785) Antibody

    Ruifei Wang, Jiajia Bi, Khamal Kwesi Ampah, Chunmei Zhang, Ziyi Li,et al (2013) Lipid raft regulates the initial spreading of melanoma A375 cells bymodulating  1 integrin clustering. The International Journal of Biochemistry & Cell Biology. 45 1679– 1689

    21278

    a-Synuclein(Ab-136) Antibody

    Shan-chuan Zhong • Xue Luo • Xing-shu Chen •Qi-yan Cai • Jing Liu • Xing-hua Chen •Zhong-xiang Yao,Expression and Subcellular Location of Alpha-Synuclein During Mouse-Embryonic Development,Cell Mol Neurobiol (2010) 30:469–482

    21279

    CaMKII (Ab-286) Antibody

    J Bossuyt, K Helmstadter, X Wu, et al. (2008)Ca2+/Calmodulin-Dependent Protein Kinase II {delta} and Protein Kinase D Overexpression Reinforce. Circulation Research, 102(6):695-702.

    21285

    MARCKS(Ab-158) Antibody

    Maria C. Olianas, Simona Dedoni, Pierluigi Onali (2011) Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3b by the recombinant human d-opioid receptor stably expressed in Chinese hamster ovary cells. Neuropharmacology. 60:1326-1336

    21286

    MEK1 (Ab-291) Antibody

    Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106

    21300

    CREB(Ab-142) Antibody

    Tomasz Boczek • Anna Kozaczuk • Bozena Ferenc •Michalina Kosiorek • Slawomir Pikula •Ludmila Zylinska, Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin, Mol Cell Biochem (2012) 360:89–102

    21302

    IGF-1R(Ab-1280) Antibody

    Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377

    21303

    IGF-1R(Ab-1346) Antibody

    Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377

    21310

    GSK3b(Ab-216) Antibody

    Ye Feng, Yiyuan Xia, Guang Yu, Xijing Shu, et al. (2013) Cleavage of GSK-3b by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3b activity induced by H2O2. J. Neurochem. 126, 234--242

    21319

    SHP-2(Ab-542) Antibody

    Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, et al. (2011) Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway. Journal of Cellular Biochemistry 112:2837–2849

    21325

    Smad3(Ab-425) Antibody

    Mitsuko Moriguchi, Marie Yamada, Yasuo Miake and Mayu Koshika. (2012) Immunolocalization of Axin2 and p-Smad3 in Developing Rat Molar Germ.Journal of Hard Tissue Biology. 21[2] p.113 - 120

    21328

    TrkB(Ab-705) Antibody

    Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272

    21390

    Myc Mouse Monoclnal Antibody

    Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.

    21390

    Myc Mouse Monoclnal Antibody

    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.

    21401

    Niban Antibody

    Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.

    21405

    STAT3(Ab-705) Antibody

    Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16

    21420

    Caspase3 Antibody

    Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326

    21488

    Vimentin Antibody

    Chuanxi Tian, Yifan Gong, Ying Yang, Wei Shen, et al.(2012) Foxg1 Has an Essential Role in Postnatal Development of the Dentate Gyrus. The Journal of Neuroscience,  32(9):2931–2949

    21507

    coflin1/cofilin2(Ab-88) Antibody

    Xiaodong Li, Qiang Ke, Yanshu Li, Funan Liu, Ge Zhu, Feng Li ,DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1 ,The International Journal of Biochemistry& Cell Biology 42 (2010) 70–79 Contents lists

    21508

    PI3K P85 a/g/b(Ab-467/199/464) Antibody

    Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411

    21508

    PI3K P85 a/g/b(Ab-467/199/464) Antibody

    Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83

    21517

    HDAC4/HDAC5/HDAC9(Ab-246/259/220) Antibody

    Weiye Wang.(2010) A Novel Role of HDAC5 in Flow-Induced Gene Expression. Department of Pharmacology and Physiology School of Medicine and Dentistry University of Rochester Rochester

    21538

    Paxillin(Ab-88) Antibody

    Ruifei Wang, Jiajia Bi, Khamal Kwesi Ampah, Chunmei Zhang, Ziyi Li,et al (2013) Lipid raft regulates the initial spreading of melanoma A375 cells bymodulating  1 integrin clustering. The International Journal of Biochemistry & Cell Biology. 45 1679– 1689

    21545

    FAK(Ab-576/577) Antibody

    Jun-shan RUAN, Yu-ping LIU1, Lei ZHANG1, Ling-geng YAN, et al. (2012) Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacologica Sinica. 33: 1325–1331

    21550

    MDM2(Ab-166) Antibody

    Hetian Lei, Gisela Velez, and Andrius Kazlauskas. (2010) Pathological Signaling via Platelet-Derived Growth Factor Receptor Involves Chronic Activation of Akt and Suppression of p53. MOLECULAR AND CELLULAR BIOLOGY, May 2011, p. 1788–1799

    21574

    b-catenin Antibody

    RONG WAN, RUI GUO, CHENG CHEN, LAI JIN,et al(2012) Urocortin Increased LPS-Induced Endothelial Permeability by Regulating the Cadherin–Catenin Complex via
    Corticotrophin-Releasing Hormone Receptor 2. JOURNAL OF CELLULAR PHYSIOLOGY. 228: 1295–1303

    21574

    b-catenin Antibody

    Chih-Kai Liaoa, Seu-Mei Wanga, Yuh-Lien Chena, Hwai-Shi Wangb, Jiahn-Chun Wu, Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3, The International Journal of Biochemistry & Cell Biology 42 (2010) 762–770

    21577

    PKM1 Antibody

    Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
    (2014), http://dx.doi.org/10.1016/j.molcel.2013.11.001

    21577

    PKM1 Antibody

    Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.

    21578

    PKM2 Antibody

    Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
    (2014), http://dx.doi.org/10.1016/j.molcel.2013.11.001

    21578

    PKM2 Antibody

    Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.

    21578

     PKM2 Antibody

    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.

    21689

    Histone H3 (Ab-27) Antibody

    MIN HUANG, JING ZHOU, LIQING BI, QIAN ZHANG, SUMING ZHOU (2012) Anti-Toll-like receptor 2 antibody, T2.1, reduces tumor necrosis factor α and interleukin-6 release and inhibits nuclear factor κB expression in bacterial lipoprotein stimulated THP-1 cells.Centr Eur J Immunol. 37 (1): 6-10

    21689

    Histone H3 (Ab-27) Antibody

    Lian-Qing Sun, Jue Zha, Ting–Ting Zhang, Ling Qu, et al. (2012) Protective Effects of Salvianolic Acid B on Schwann Cells Apoptosis Induced by High Glucose. Neurochem Res 37:996–1010

    21689

    Histone H3 (Ab-27) Antibody

    Lian-Qing Sun, Bing Xue, Xiao-Jin Li, Xuan Wang, Ling Qu, Ting-Ting Zhang, Jue Zhao, Bao-An Wang, Xiao-Man Zou, Yi-Ming Mu, Ju-Ming Lu,Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose,Life Sciences 90 (2012) 99–108

    22267

    ZNF346 antibody

    Yan Chen, Shen Yue, Lu Xie, Xiao-hong Pu,Tian Jin and Steven Y. Cheng, Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 15, pp. 13502–13511, April 15, 2011

    22966

    ADP-ribosylation factor 3 antibody

    Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195

    23220

    STAT3 Antibody

    Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125

    23630

    EGFR Antibody

    Frédéric Couture, François D’Anjou,Roxane Desjardins, François Boudreau and Robert Day, Role of Proprotein Convertases in Prostate Cancer Progression, Neoplasia (2012) 14, 1032–1042

    24050

    Caspase-9 Antibody

    Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195

    24250

    Bax Antibody

    Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently
    induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–139

    24313

    4E-BP1 Antibody

    Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215

    24317

    anti-Irs1

    Daisuke Ekuni, Takaaki Tomofuji, Koichiro Irie, Kenta Kasuyama, Michihiro Umakoshi, Tetsuji Azuma,Naofumi Tamaki, Toshihiro Sanbe, Yasumasa Endo, Tatsuo Yamamoto, Takashi Nishida and Manabu Morita,Effects of periodontitis on aortic insulin resistance in an obese rat model,Laboratory Investigation (2010) 90, 348–359

    24458

    PKR Antibody

    Suzette Laing,1* Guohui Wang,1* Tamara Briazova,1 Chunbin Zhang,1 Aixia Wang,5 Ze Zheng,1Alexander Gow,1,3,4 Alex F. Chen,8 Sanjay Rajagopalan,5 Lung Chi Chen,7 Qinghua Sun,5,6§ and Kezhong Zhang1,2,Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues, Am J Physiol Cell Physiol 299: C736–C749, 2010.

    24534

    Bub3 Antibody

    Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
    (2014), http://dx.doi.org/10.1016/j.molcel.2013.11.001

    25541

    β-catenin Antibody

    Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17

    29022

    TNF alpha antibody

    Desong Kong, Feng Zhang, Donghua Wei, Xiaojing Zhu, et al.(2013) Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-kB pathway in activated stellate cells: In vivo and in vitro studies. Journal of Gastroenterology and Hepatology. 28:1223–1233

    29101

    Caspase 3 Antibody

    Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195

    29139

    MAVS Antibody

    Wang B, Xi X, Lei X, Zhang X, Cui S, et al. (2013) Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses. PLoS Pathog 9(3): e1003231. doi:10.1371/journal.ppat.1003231

    29162

    ERK1/2

    Yinbo Niu, Yuhua Li, Haitao Huang, Xianghe Kong, et al. (2011) Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway. Phytother. Res. 25: 1700–1706

    29162

    ERK1/2 Antibody

    Zhifeng Wei,1 Jian Yang,1 Yu-Feng Xia,1 Wen-Zhe Huang,2 Zheng-Tao Wang,2 and Yue Dai, Cardamonin Protects Septic Mice from Acute Lung Injury by Preventing Endothelial Barrier Dysfunction, J BIOCHEM MOLECULAR TOXICOLOGY,Volume 26, Number 7, 2012

    29227

    PLC gamma 1 Antibody

    Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu, Thanasekaran Jayakumar, et al. (2010) Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology & Medicine. 49:881–893

    51041

    NF-kB p65(Phospho-Ser536) antibody blocking peptide

    KEFENG WU, YI LIU1, YINGNIAN LV, LIAO CUI, et al. (2013) Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis and cell cycle arrest in CNE-2Z nasopharyngeal carcinoma cells. ONCOLOGY REPORTS. 29: 2101-2108

    51080

    EGFR(Phospho-Ser1070) antibody blocking peptide

    Frédéric Couture, François D’Anjou,Roxane Desjardins, François Boudreau and Robert Day, Role of Proprotein Convertases in Prostate Cancer Progression, Neoplasia (2012) 14, 1032–1042

    51111

    Tau(Phospho-Ser262) antibody blocking peptide

    J. BERTRAND, V. PLOUFFE, P. SÉNÉCHAL AND N. LECLERC, THE PATTERN OF HUMAN TAU PHOSPHORYLATION IS THE RESULT OF PRIMING AND FEEDBACK EVENTS IN PRIMARY HIPPOCAMPAL NEURONS, Neuroscience 168 (2010) 323–334

    51136

    FKHR(Phospho-Ser319) antibody blocking peptide

    Tomoko Kanao, Katerina Venderova, David S. Park, Terry Unterman, et al.(2010) Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Human Molecular Genetics, Vol. 19, No. 19 3747–3758

    51136

    FKHR(Phospho-Ser319) antibody blocking peptide

    Kanao T, Sawada T, Davies S-A, Ichinose H, Hasegawa K, et al. (2012) The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. PLoS ONE 7(2): e30958. doi:10.1371/journal.pone.0030958

    51174

    AMPK1/AMPK2(Phospho-Ser485/Ser491) antibody blocking peptide

    Sheng-Yang Jiang, Ming Xu, Xiao-Wei Ma, Han Xiao, et al.(2010) A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. Clinical and Experimental Pharmacology and Physiology. 37:919–925

    51193

    HDAC5(Phospho-Ser498) antibody blocking peptide

    Sheng Xia, Xiaogang Li, Teri Johnson, Chris Seidel, Darren P. Wallace, and Rong Li (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. Volume 137, Pages 1075-1084

    51221

    mTOR(Phospho-Ser2448) antibody blocking peptide

    MM Sun, MZ Zhang, Y Chen, SL Li, W Zhang, GW Ya and KS Chen,Mechanistic Target of pamycin Small Interfering RNA and Rapamycin Synergistically Inhibit Tumour Growth in a Mouse enograft Model of Human Oesophageal Carcinoma,The Journal of International Medical Research 2012; 40: 1636 – 1643

    11174

    anti-phospho-AMPKα1 (phospho-Ser487)

    Yan-Na Huang, Jian-Hua Qi, Lan Xiang , Yi-Zhen Wang(2012)Construction of adiponectin-encoding plasmid DNA and overexpression in mice in vivo.Gene 502 (2012) 87–93

    I4001

    Rabbit IgG

    Jing Qian, Chunyan Zhang, Xiaodong Cao, et al (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anaytical Chemistry,82 (15), 6422–6429

    I4001

    Rabbit IgG

    Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu (2011) Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization. Biosensors and Bioelectronics, Volume 26, Issue 9, Pages 3788-3793

    I4001

    Rabbit IgG

    Jing Qian, Haichao Dai, Xiaohu Pan, Songqin Liu, et al (2011) Simultaneous detection of dual proteins using quantum dots coated silica nanoparticles as labels. Biosensors and Bioelectronics, Volume 28, Issue 1, Pages 314-319

    L3011

    Goat anti-Rabbit IgG Secondary antibody unconjugated

    Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu (2011) Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization. Biosensors and Bioelectronics, Volume 26, Issue 9, Pages 3788-3793

    L3011

    Goat anti-Rabbit IgG Secondary antibody unconjugated

    Jing Qian, Haichao Dai, Xiaohu Pan, Songqin Liu, et al (2011) Simultaneous detection of dual proteins using quantum dots coated silica nanoparticles as labels. Biosensors and Bioelectronics, Volume 28, Issue 1, Pages 314-319

    L3011

    Goat anti-Rabbit IgG Secondary Antibody Unconjugated

    Jing Qian, Chunyan Zhang, Xiaodong Cao, and Songqin Liu. (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anal. Chem. 82:6422–6429

    L3011

    Goat anti-Rabbit IgG Secondary Antibody Unconjugated

    Liang Yuan, Yafeng Wu, Hongyan Shi, and Songqin Liu. (2011) Surface-Initiated Atom-Transfer Radical Polymerization of 4-AcetoxyACHTUNGTRENUNGstyrene for Immunosensing. Chem. Eur. J.  17:976–983

    L3012

    Goat anti-Rabbit IgG Secondary antibody HRP conjugated

    Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106

    L3012

    Goat anti-Rabbit IgG Secondary antibody HRP conjugated

    Jing Qian, Chunyan Zhang, Xiaodong Cao, et al (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anaytical Chemistry,82 (15), 6422–6429

    L3012

    Goat anti-Rabbit IgG Secondary Antibody HRP conjugated

    Yonggen Jia, Xinxin Zhao, Jingru Zou, Xun Suo. (2011) Trypanosoma evansi: Identification and characterization of a variant surface glycoprotein lacking cysteine residues in its C-terminal domain. Experimental Parasitology 127:100–106

    L3012

    Goat anti-Rabbit IgG Secondary Antibody HRP conjugated

    Yudong Liu, Ying Su, Shenggang Sun, Tao Wang, et al. (2012) Tau Phosphorylation and m-Calpain Activation Mediate the Dexamethasone-Induced Inhibition on the Insulin-Stimulated Akt Phosphorylation. PLoS ONE 7(4): e35783. doi:10.1371/journal.pone.0035783

    L3012

    Goat anti-Rabbit IgG Secondary Antibody HRP conjugated

    YONG CHENG, LI-YOU AN, YU-GUO YUAN, YI WANG, et al. (2012) Hybrid Expression Cassettes Consisting of a Milk Protein Promoter and a Cytomegalovirus Enhancer Significantly Increase Mammary-Specific Expression of Human Lactoferrin in Transgenic Mice. Molecular Reproduction & Development 79:573–585

    L3012

    Goat anti-Rabbit IgG Secondary Antibody HRP conjugated

    Saito S, Yamamoto H, Mukaisho K-i, Sato S, Higo T, et al. (2013) Mechanisms Underlying Cancer Progression Caused by Ezrin Overexpression in Tongue Squamous Cell Carcinoma. PLoS ONE 8(1): e54881. doi:10.1371/journal.pone.0054881

    L3012

    Goat anti-Rabbit IgG Secondary Antibody HRP conjugated

    Ing-Chien Chen,za Chung-Ming Yu,za Yu-Ching Lee,a Yi-Jen Huang,ab Hung-Ju Hsuac and An-Suei Yang, Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF,Mol. BioSyst., 2010, 6, 1307–1315 | 1307

    L3032

    Goat anti-Mouse IgG Secondary Antibody HRP conjugated

    Lei Wu, Ya-nan Jiang, Qian Tang, Hui-xing Lin, et al. (2012) Development of an Aeromonas hydrophila recombinant extracellular protease vaccine. Microbial Pathogenesis. 53:183-188

    L3032

    Goat anti-Mouse IgG Secondary Antibody HRP conjugated

    Jossimara Polettini a,*, Eliane Passarelli Vieira a, Mariana Perlati dos Santos a, Jose´ Carlos Perac¸oli b,Steven S. Witkin c, Ma´ rcia Guimara˜es da Silva, Interleukin 18 messenger RNA and proIL-18 protein expression in chorioamniotic membranes from pregnant women with preterm prelabor rupture of membranes, European Journal of Obstetrics & Gynecology andReproductive Biology 161 (2012) 134–139

    L3041

    Rabbit anti-Goat IgG Secondary antibody unconjugated

    Jing Qian, Chengquan Wang, Xiaohu Pan, Songqin Liu (2013) A high-throughput homogeneous immunoassay based on Förster resonance energy transfer between quantum dots and gold nanoparticles. Analytica Chimica Acta. 763:43– 49

    L3042

    Rabbit anti-Goat IgG HRP conjugated

    Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu, Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization, Biosensors and Bioelectronics 26 (2011) 3788–3793

    L3042

    Rabbit anti-Goat IgG HRP conjugated

    Gyula Acsadi & Xingli Li & Kelley J. Murphy &Kathryn J. Swoboda & Graham C. Parker, Alpha-Synuclein Loss in Spinal Muscular Atrophy, J Mol Neurosci (2011) 43:275–283

    L3051

    Rabbit anti-Humant IgG Secondary antibody unconjugated

    Jing Qian, Chengquan Wang, Xiaohu Pan, Songqin Liu (2013) A high-throughput homogeneous immunoassay based on Förster resonance energy transfer between quantum dots and gold nanoparticles. Analytica Chimica Acta. 763:43– 49

    L3052

    Rabbit anti-Human IgG secondary antibody HRP-conjugated

    Loris Riccardo Lopetusoa, Valentina Petitoa, Valerio Cufinob, Vincenzo Arenab, Egidio Stigliano b, Viviana Gerardia, Eleonora Gaetania, Andrea Posciad, Arianna Amatoc, Giovanni Cammarotaa, Alfredo Papaa, Alessandro Sgambatob, Antonio Gasbarrinia, Franco Scaldaferri ,Locally injected Infliximab ameliorates murine DSS colitis: Differences in serum and intestinal levels of drug between healthy and colitic mice, L.R. Lopetuso et al. / Digestive and Liver Disease xxx (2013) xxx– xxx

    T501

    HA-Tag Rabbit Polyclonal Antibody

    Yuan Qiu, Yan Ding, Lingyun Zou, Zhangping Tan, et al (2013) Divergent Roles of Amino Acid Residues Inside and Outside the BB Loop Affect Human Toll-Like Receptor (TLR)2/2, TLR2/1 and TLR2/6 Responsiveness. PLoS ONE 8(4): e61508. doi:10.1371/journal.pone.0061508

    T501

    HA-Tag Rabbit Polyclonal Antibody

    Sai Srinivas Panapakkam Giridharan, Bishuang Cai, Nicolas Vitale, Naava Naslavsky, et al. (2013) Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. Molecular Biology of the Cell. Volume 24:1776-1790

    T501

    HA-Tag Rabbit Polyclonal Antibody

    Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560

    T501

    HA-Tag Rabbit Polyclonal Antibody

    Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.

    T502

    HA-Tag Mouse Monoclonal Antibody

    Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.

    T503

    polyclonal DYKDDDDK tag

    Juliette Gafni, Xin Cong, Sylvia F. Chen, et al.(2009) Calpain-1 Cleaves and Activates Caspase-7J. Biol. Chem., 284: 25441 - 25449.

    T503

    DYKDDDDK-Tag Rabbit Polyclonal Antibody

    Wang Jian, Zou Ning, Pan Xuwen, Liu Sidang.Establishment of a Cell Line with Stable Expression of HLA-A33 Protein[J].Biotechnology Bulletin, (2011) 11:212-215

    T507

    GFP-Tag mouse mAb

    Qianqian Li, Hongbin Zhang, Cui Tan, Weiyan Peng, et al. (2013) AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells. Tumor Biol.DOI 10.1007/s13277-013-0936-3

  • 癌症相关信号通路

     Akt Pathway 
     Apoptosis Pathway 
     Cell Cycle Regulation 
     Channel Pathway 
     Chromatin/Transcription Regulation 
     Cytoskeleton/Adhesion 
     DNA Damage/Repair 
     Immune System Regulation 
     Insulin/Glucose Metabolism 
     Jak/Stat Pathway 
     Kinases/Phosphatases 
     MAPK Pathway
     NF-kappa B Pathway
     RTKs/Adaptors
     Stem Cell Regulation
     TGFb/smads Pathway
     Translation Regulation 
     Wnt/Notch/Hedgehog Pathway 
  • 2013年SAB目录

     

     Signalway Antibody 2013 catalogue
     
     
     
     

     

     

  • 癌基因/抑癌基因蛋白

     
     An oncogene is a gene that has the potential to cause cancer.[ In tumor cells, they are often mutated or expressed at high levels. Most normal cells undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells that ought to die to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target the proteins encoded by oncogenes.
    A proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. The resultant protein may be termed an oncoprotein. Proto-oncogenes code for proteins that help to regulate cell growth and differentiation. Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products. 
    Suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. Tumor-suppressor genes either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both.
     
    Selected Reviews:
    Croce CM (2008) Oncogenes and cancer. N Engl J Med. 358 (5): 502-11
    Yokota J (2000) Tumor progression and metastasis. Carcinogenesis. 21 (3): 497-503
    May P (1999) Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene. 18(53):7621-36
    Melamud A (2006) Retinoblastoma. Am Fam Physician 73 (6): 1039-44
     
  • 细胞周期

     

    Cell cycle, or cell-division cycle, is the series of events that take place in a cell leading to its division and duplication (replication). Cell cycle control affects many aspects of development. Caenorhabditis elegans cell-cycle genes have been identified over the past decade, including at least two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and negative regulators, and downstream targets. The balance between CDK activation and inactivation determines whether cells proceed through G1 into S phase, and from G2 to M, through regulatory mechanisms that are conserved in more complex eukaryotes. Many different stimuli exert checkpoint control including TGF, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. G1 phase CDKs and their inhibitors (CKIs) are central to the pathways that regulate commitment to cellular division in response to positive as well as negative growth effectors. Many checkpoints are deregulated in oncogenesis, and this is often due to alterations in cyclin-CDK complexes.CDK activity is modulated by cyclin binding, phosphorylation, and CKIs, including the INK4 proteins and the closely related inhibitors p21Cip1 and p27Kip1. The downstream targets of CDKs and their modulation by TGF-beta and other growth factors include proteins of the retinoblastoma family, and the related modulation of the transcriptional activity of the E2F family members.

    A disregulation of the cell cycle components may lead to tumor formation. As mentioned above, some genes like the cell cycle inhibitors, RB, p53 etc., when they mutate, may cause the cell to multiply uncontrollably, forming a tumor. The cells which are actively undergoing cell cycle are targeted in cancer therapy.  

     
    Selected Reviews: 
    Dyson, N. (1998) The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262. 
    Elledge SJ. (1996) Cell cycle checkpoints: preventing an identity crisis. Science. 274(5293):1664-72.
    Ravitz MJ, Wenner CE. (1997)Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-beta. Adv Cancer Res. 71:165-207.
    van den Heuvel S.(2005) Cell-cycle regulation. WormBook. 21:1-16. 
     
  • 癌症干细胞标志物

     

     

    Cancer cells found within tumors or hematological cancers that possess characteristics associated with normal stem cells , specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are proposed to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for sufferers of metastatic disease .
    A number of studies have focused on identifying specific cancer stem cell markers. Pancreatic cancer stem cells express the surface markers CD44, CD24 and epithelial specific antigen (ESA). It has also been identified that liver progenitor cells share molecular markers with adult hepatocytes and fetal hepatocytes. In addition, markers frequently used to identify adult stem cells within the prostate, breast and intestine include CD44, CD133, ESA, CD69, p63, as well as some stem cell antigen, such as CD34, c-kit, Flt-3, NCAM, and Thy-1.
     
     
    Selected Reviews:
    Gupta PB (2009) Cancer stem cells: mirage or reality?. Nat Med 15 (9): 1010-2. 
    Singh SK (2003) Identification of a cancer stem cell in human brain tumors. Cancer Research 63 (18): 5821-8
    Li C (2007) Identification of pancreatic cancer stem cells. Cancer Research 67 (3): 1030-7
    Dingli D. (2006) Successful therapy must eradicate cancer stem cells. Stem Cells 24, 2603-10. 

     

    Cancer Stem Cell Markers Related Products

  • 癌症生物标志物

     

     

     

    Cancer biomarkers are substances indicate that tumor state, progression characteristics, and response to therapies. Most cancer biomarkers are transcription factors, cell surface receptors, or secreted proteins that are produced by either cancer cells or other cells in response to cancer. They are present in tumor tissues or body fluids. Cancer biomarkers can be used for screening the general population, for differential diagnosis in symptomatic patients, and for clinical staging of cancer. Additionally, cancer biomarkers can be used to estimate tumor volume, to evaluate response to treatment, to assess disease recurrence through monitoring, or as prognostic indicators of disease progression. During the last decade, improved understanding of carcinogenesis and tumor progression has revealed a large number of potential cancer markers. It is predicted that even more will be discovered in the near future with the application of the new emerging genomics and proteomics technologies.

    Selected Reviews:
    Ludwig JA( 2005) Biomarkers in cancer staging, prognosis and treatment selection. Nat. Rev. Cancer 5 (11): 845-56. 
    Kulasingam V, et al. (2007) Tissue culture-based breast cancer biomarker discovery platform. Int J Cancer. 123(9):2007-12.
    Singer E. A.(2007) PSA Screening and Elderly Men. JAMA 297 (9): 949
    Jacobs Jon M.(2005) Utilizing Human Blood Plasma for Proteomic Biomarker Discovery. Journal of Proteome Research 4 (4): 1073-85 

     

    Cancer biomarkers Related Products

  • 细胞凋亡

     

     
    Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and function of an organism and is a regulated physiological process leading to cell death. 
    In apoptosis pathways, signaling results in the activation of a family of Cysteine Proteases, named Caspases that act in a proteolytic cascade to dismantle and remove the dying cell, are central regulators of apoptosis. Initiator caspases (including 8, 9, 10) are closely coupled to pro-apototic signals. Once activated, these caspases cleave and activate downstream effector caspases (3, 6, 7) which in turn cleave cytoskeletal and nuclear proteins and induce apoptosis. Cytochrome C released from damaged mitochondria is coupled to the activation of caspase 9. 
    Pro-apoptotic stimuli include the FasL, TNF, DNA damage. Fas and TNFR activate caspases 8 and 10; DNA damage leads to the activation of caspase 9. Anti-apoptotic ligands including growth factors and cytokines activate AKT and p90RSK, which inhibit Bad and prevent cytochrome C release. TNFR can also stimulate an anti-apoptotic pathway by inducing IAP, which directly inhibits caspases 3, 7 and 9. 
    Alternatively, apoptosis is inhibited via an adaptor protein complex which activates NF-kB and induces survival genes including IAP. The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and the release of cytochrome C. The anti-apoptotic proteins Bcl-2 and Bcl-xL reside in the outer mitochondrial wall and inhibit cytochrome C release. The pro- apoptotic Bcl-2 proteins Bad, Bid, Bax and Bim reside in the cytosol but translocate to mitochondria following death signaling, where they promote the release of cytochrome C. Bad translocates to mitochondria and forms a pro-apoptotic complex with Bcl-xL. This translocation is inhibited by survival factors that induce the phosphorylation of Bad, leading to its cytosolic sequestration. Bax and Bim translocate to mitochondria in response to death stimuli, including survival factor withdrawal. Bcl-xL, Bcl-2 and Bax apparently influence the voltage-dependent anion channel (VDAC), which can control cytochrome C release. p53, activated following DNA damage, induces the transcription of Bax. Released cytochrome C binds Apaf1 and forms an activation complex with caspase9. 
     
     
    Selected Reviews:
    Alberts Bruce (2008) Chapter 18 Apoptosis: Programmed Cell Death Eliminates Unwanted Cells. Molecular Biology of the Cell (textbook) (5th ed.). Garland Science. p. 1115. ISBN 978-0-8153-4105-5.
    Czerski L. (2004) Apoptosome formation and Caspase activation:is it different in the heart. J Mol Cardiol.37(13),643-652. 
    Debatin K.M.(2004) Death receptors in chemotherapy and cancer. Oncogene 23(16), 2950-66. 
    Lamkanfi M. (2007) Caspases in cell survival, proliferation and differentiation. Cell Death and Differentiation 14 (1): 44-55.
     
     
  • 血管生成

     
     Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, and is a normal and vital process in growth and development, as well as in wound healing and in granulation tissue. Angiogenesis is regulated by multiple factors, including growth and differentiative factors, extracellular matrix components, membrane-bound receptors, intracellular signaling molecules, and angiogenesis inhibitors. Several growth factors, including FGFs (fibroblast growth factors), VEGFs (vascular endothelial growth factors), PDGFs, eprins, angiopoietins, TGF-beta and other participate in regulating angiogenesis. Angiogenesis inhibitors can be endogenous or exogenous. Endogenous angiogenesis inhibitors may be interleukins, interferons, chemokines, or growth factor regulators.
     
    In health, the body maintains a balance of angiogenesis regulators. However, the structures formed are often functionally abnormal, possibly due to an imbalance in the angiogenic process. Imbalance of angiogenesis stimulation and inhibition can lead to disease. In cancer, like tissues of the body, tumors need a blood supply. They get this through new blood vessel formation (angiogenesis). This is a fundamental step in the transition of tumors from a dormant state to a malignant one. 
     
    Selected Reviews:
    Risau W. (1995) Vasculogenesis. Annual review of cell and developmental biology. 11: 73-91. 
    Carmeliet P. (2005) Angiogenesis in life, disease and medicine. Nature. 438(7070):932-6.
    Tan A. (2010) Angiogenesis-inhibitors for metastatic thyroid cancer. Cochrane Database Syst Rev.3:CD007958.
    Flamme I. (1997) Molecular mechanisms of vasculogenesis and embryonic angiogenesis. Journal of cellular physiology 173 (2): 206-10. 
      

     Angiogenesis Related Products  

  • 粘附分子

     
    Adhesion Molecules are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process of cell adhesion or cellular interactions. Essentially, adhesion molecules help cells stick to each other and to their surroundings. Adhesion Molecules include Integrins, Ig superfamily Cell Adhesion Molecules (CAMS), Cadherins, Lectins, and others. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton , a transmembrane domain, and an extracellular domain. 
     
    Adhesion molecules play critical roles in a variety of biological processes. For instance, one important part adhesion molecules serve in the immune system is to enhance pairing between many less avid receptors and their ligands and transmit signals that direct specific effecter functions during an inflammatory response. In development they play key roles in tissue morphogenesis, cell migration, and axon guidance. Pathologically, adhesion molecules have been discovered to play a critical role in tumor cell invasiveness and metastases.
     
    Selected Reviews:
    Angst B. (2001)The cadherin superfamily: diversity in form and function. J Cell Sci. 114 (Pt 4): 629-41
    Zetter BR. (1993) Adhesion molecules in tumor metastasis. Semin Cancer Biol. 4(4):219-29.
    Hulpiau P. (2009)Molecular evolution of the cadherin superfamily. Int. J. Biochem. Cell Biol.. 41 (2): 349-69.
    Ikeda H. (1998) Cell adhesion molecule. Nippon Rinsho. 56(10):2493-9.
     
     
  • Wnt/Notch/Hedgehog signaling pathway

    SAB 

     

    Pathway description:
    During development, Wnt (Wingless-Type MMTV Integration Site Family) have diverse roles in governing cell fates, proliferation, migration, polarity, and death. In the absence of Wnt signaling, β-Catenin is associated with a cytoplasmic complex containing CK1, GSK3, Axin, APC and PP2A. This promotes phosphorylation of course β-Catenin and its interaction with β-TRCP, leading to the ubiquitination of β-Catenin and its degradation by the proteosome. In the presence of Wnt signaling, secreted Wnt glycoproteins bind to the receptor Frizzled, which leads to activation of the Dishevelled (Dsh) protein, a PDZ domain protein. Dsh acts to inhibit a cytoplasmic complex involving GSK3, Axin and APC that acts to degrade β-Catenin. GSK3 phosphorylates β-Catenin leading to ubiquitination and degradation by the proteosome. Activation of the Wnt/beta-catenin pathway inhibits degradation of β-Catenin allowing its nuclear transport and gene induction via bindng to TCF. During the elaboration of cell types and tissues, the Wnt/beta-catenin pathway often interacts with the FGF and TGF-β pathways. In adults, Wnt function in homeostasis, and inappropriate activation of the Wnt/beta-catenin pathway is implicated in a variety of cancer. 

     

    Selected Reviews:
    Li F,Chong zz,et al.(2006)Winding through the WNT pathway during cellular development and demise.Histol Histopathol.21(1),103.
    Katoh M.(2005)Comparative genomics on Wnt5a and Wnt5b genes.Int J Mol Med.15(4),749.
    Li F,Chong zz,et al.(2005)Vital elements of the Wnt-Firizzled signaling pathway in the nervous system.Curr Neurovasc Res.2(4),331.
    Urano T.(2006)Wnt- beta-catenin signaling in bone metabolism.Clin Calcium. 16 (1),54.
  • 翻译信号通路

     

     Pathway description: 
    Translation initiation is a complex process in which initiator tRNA, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the initiation codon of mRNA. The cap-binding complex eIF4F and the factors eIF4A and eIF4B are required for binding of 43S complexes (comprising a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5′ end of capped mRNA but are not sufficient to promote ribosomal scanning to the initiation codon. 
    The eukaryotic translation initiation factor 4F (eIF4F) mediates 40S ribosomal subunit binding to the 5'end of capped mRNA. eIF4F is a complex containing three proteins: eIF4E, the cap-binding subunit; eIF4A, an RNA-dependent ATPase/ATP-dependent RNA helicase; and eIF4G, a high-molecular-weight protein that acts as a scaffold for binding eIF4E and eIF4A. In addition, eIF4G interacts with the 40S ribosome binding factor eIF3 and the poly(A)-binding protein, thereby establishing a critical link between mRNA and the ribosome. The various eIF4F subunits are expressed to remarkably different levels in most cell types, with the eIF4E subunit being the least abundant.  
     

    References:  
    Anthony, D. D., and W. C. Merrick. (1991) Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation. J. Biol. Chem. 266,10218-10226   Avdulov, S. et al. (2004) Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5,553-563.  
    Gingras, A. C.,et al. (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68,913-963.  
    Hentze, M. W. (1997) eIF4G: a multipurpose ribosome adapter? Science 275,500-501
    Hershey, J. W. B., and W. C. Merrick.(2000) Translational control of gene expression Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. 
  • TGFb/smads signaling pathway

     

  • MAPK signaling pathway

     
    Pathway description:
    Intracellular signaling cascades are the main routes of communication between the Plasma membrane and regulatory targets in various intracellular compartments. Sequential activation of Kinases is a common mechanism of signal transduction in many cellular processes. During the past decade, several related intracellular signaling cascades have been elucidated, which are collectively known as MAPK (Mitogen-Activated Protein Kinase) signaling cascades. The MAPKs are a group of protein Serine/threonine Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. In combination with several other signaling pathways, they can differentially alter phosphorylation status of numerous proteins. There are four major groups of MAPKs in mammalian cells-the ERKs, the p38MAPKs, the JNKs and the ERK5 or BMK cascades. These MAPKs are actived by dual phosphorylation at the tripeptide motif Thr-Xaa-Tyr. Each MAPK pathway contains a three-tiered kinase cascade comprising a MAPKKK, a MAPKK and the MAPK. Frequently, a MAPKKKK activates the MAPKKK.The MAPKKK then phosphorylates a dual-specificity protein kinase MAPKK, which in turn phosphorylates the MAPK.p38MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, the Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

    Selected Reviews:
    Wada T,Penninger JM.(2004)Mitogen-activated protein kinase in apoptosis regulation. Oncogene. 23(16),2838
    Panka DJ,Atkins MB,et al.(2006)Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma.Clin Cancer Res.12(7Pt2),2371s.
    Dunn KL, Espino PS, Drobic B, et al.(2005)The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. Biochem Cell Biol. 83(1):1-14  
  • 激酶/磷酸酶信号通路

    Pathway description:
    kinase, alternatively known as a phosphotransferase, is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation . The largest group of kinases are protein kinases, which act on and modify the activity of specific proteins. kinase are used extensively to transmit signals and control complex processes in cells. Up to 518 different kinases have been identified in humans. Their enormous diversity and role in signaling makes them attractive targets for drug design. Various other kinases act on small molecules (lipids, carbohydrates, amino acids, nucleotides, and more), either for signaling or to prime them for biochemical reactions in metabolism. These are named after their substrates.
    Deregulated kinase activity is a frequent cause of disease, particularly cancer, where kinases regulate many aspects that control cell growth, movement and death. Drugs which inhibit specific kinases are being developed to treat several diseases, and some are currently in clinical use
    A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to that of phosphorylases and kinases, which attach phosphate groups to their substrates by using energetic molecules like ATP. The addition of a phosphate group may activate or de-activate an enzyme (e.g., Kinase signalling pathways ) or enable a protein-protein interaction to occur (e.g., SH3 domains); therefore phosphatases are integral to many signal transduction pathways.
    Therefore ,kinase and phosphatases are closely attached to each other in regulating various cellular events, and play an important role in signal transduction, 
    References:
    Ladbury, JE. (2007)Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction, Acta Cryst D,62,pp26
    Zhong-Yin Zhang, (2002) PROTEIN TYROSINE PHOSPHATASES: Structure and Function, Substrate Specificity, and Inhibitor Development, Annual Review of Pharmacology and Toxicology 42, pp209 
    Mumby, MC & Walter, (1993) G. Protein Serine/Threonine Phosphatases: Structure, Regulation, and Functions in Cell Growth  Physiological Reviews,73,pp673
  • Jak/Stat signaling pathway

    Pathway description:
    The Janus Kinase (JAK) and signal transducers and activators of transcription (STAT) pathway has been shown to play a key role in cytokine-mediated signal transduction, and to regulate growth, differentiation, and death of both normal and transformed cells. 
    The JAK/STAT pathway represents one such signaling cascade whose evolutionarily conserved roles include cell proliferation and haematopoiesis. Jak belongs to a family of non-receptor protein tyrosine kinase of approximately 130kDa, comprising of Jak1, Jak2, Jak3 and Tyk2. 
    JAK activation occurs upon ligand-mediated receptor multimerization because two JAKs are brought into close proximity, allowing trans-phosphorylation. The activated JAKs subsequently phosphorylate additional targets, including both the receptors and the major substrates, STATs. STATs are latent transcription factors that reside in the cytoplasm until activated. The seven mammalian STATs bear a conserved tyrosine residue near the C-terminus that is phosphorylated by JAKs. This phosphotyrosine permits the dimerization of STATs through interaction with a conserved SH2 domain. Phosphorylated STATs enter the nucleus by a mechanism that is dependent on importin -5 (also called nucleoprotein interactor 1) and the Ran nuclear import pathway. 
    Once in the nucleus, STAT dimers bind specific enhancers, regulating the transcription of target genes. In addition to activating STATs, Jak kinases phosphorylate other signaling/adaptor proteins, linking Jak signaling to other pathways such as the MAP kinases. These parallel regulatory pathways are important in shaping the specificity of cellular responses to various cytokines.
     
    Selected Reviews: 
    Ananthakrishnan R,Hallam K,et al.(2005)JAK-STAT pathway in cardiac ischemic stress.Vascul Pharmacol. 
    Walker JG,Smith MD.(2005)The JAK-STAT pathway in rheumatoid arthritis.J Rheumatol.32(9),1650-3. 
    Rawlings JS, Rosler KM, Harrison DA.(2004)The JAK/STAT signaling pathway. J Cell Sci. 117(Pt 8):1281-3.
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