产品详情
产品名称TET1 antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were purified by affinity purification using immunogen.
应用WB,IHC,IF
种属反应性Human,Mouse,Rat
特异性The antibody detects endogenous level of total TET1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant protein of human TET1.
基因/蛋白名称TET1
别名LCX; CXXC6; bA119F7.1;TET1
数据库入口号Swiss-Prot#: Q8NFU7
NCBI Gene ID: 80312
UniprotQ8NFU7
实际分子量235kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of HeLa cells using TET1 Polyclonal antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of A-431 cells, using TET1 antibody.
Immunohistochemistry of paraffin-embedded mouse spleen using TET1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse testis using TET1 antibody at dilution of 1:100 (40x lens).
背景
TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman¡¯s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
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PMID: 35155564