产品详情
产品名称Cytochrome C Antibody
来源种属Rabbit
克隆性Polyclonal
应用WB
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of total Cytochrome C protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.71-75(N-P-K-K-Y) derived from Human Cytochrome C.
基因/蛋白名称Cytochrome C
别名CYC, HCS, THC4,
浓度1.0mg/ml
应用详情
Predicted MW: 14kd
Western blotting: 1: 500~1: 1000
背景
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
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