产品详情
产品名称TNF alpha Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Immunogen affinity purified
应用WB
种属反应性Ms
免疫原描述peptide
别名APC1 antibody APC1 protein antibody Cachectin antibody DIF antibody Differentiation inducing factor antibody Macrophage cytotoxic factor antibody Tnf antibody TNF superfamily, member 2 antibody TNF, macrophage derived antibody TNF, monocyte derived antibody TNF-a antibody TNF-alpha antibody TNFA antibody TNFA_HUMAN antibody TNFSF2 antibody Tumor necrosis factor alpha antibody Tumor necrosis factor antibody Tumor necrosis factor ligand superfamily member 2 antibody Tumor Necrosis Factor, Membrane Form antibody Tumor necrosis factor, soluble form antibody
数据库入口号Swiss-Prot#:P06804
计算分子量17 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1000
背景
TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. Membrane bound TNF-α is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer. Both membrane and soluble forms of TNF-α are biologically active. TNF-α is produced by a variety of immune cells including T cells, B cells, NK cells and macrophages. TNF-α plays a key regulatory role in infammation and host defense against bacterial infection, notably Mycobacterium tuberculosis.
背景文献
1.Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56. 2.Hehlgans, T. and Pfeffer, K. (2005) Immunology 115, 1-20. 3.Lin, P.L. et al. (2007) J Investig Dermatol Symp Proc 12, 22-5. 4.Brennan, F.M. and McInnes, I.B. (2008) J Clin Invest 118, 3537-45.
Yes
