产品详情
产品名称Insulin Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性SA0410
纯化ProA affinity purified
应用ICC/IF, IHC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名IDDM antibody
IDDM1 antibody
IDDM2 antibody
ILPR antibody
ins antibody
INS_HUMAN antibody
Insulin A chain antibody
Insulin B chain antibody
IRDN antibody
MODY10 antibody
Preproinsulin antibody
Proinsulin antibody
Proinsulin precursor antibody
数据库入口号Swiss-Prot#:P01308
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
IHC: 1:100-1:500
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded rat pancreas tissue using anti-Insulin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-Insulin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Insulin antibody. Counter stained with hematoxylin.
背景
Insulin is a hormone with extensive effects on both metabolism and several other body systems. It causes most of the body's cells to take up glucose from the blood (including liver, muscle, and fat tissue cells), storing it as glycogen in the liver and muscle, and stops use of fat as an energy source. Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to its secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide.
背景文献
1. Johansson U et al. Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices. PLoS One 10:e0130169 (2015).
2. Hoelen H et al. Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97. PLoS One 10:e0128206 (2015).
Yes
