产品详情
产品名称JNK1+JNK2+JNK3 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性SA43-06
纯化ProA affinity purified
应用WB, ICC/IF, IP
种属反应性Hu, Ms, Rt, Cow, Monkey, zebrafish
免疫原描述recombinant protein
别名C Jun kinase 2 antibody
c Jun N terminal kinase 1 antibody
c Jun N terminal kinase 2 antibody
c Jun N terminal kinase 3 antibody
c-Jun N-terminal kinase 1 antibody
JNK 46 antibody
JNK 55 antibody
JNK antibody
JNK-46 antibody
JNK1 antibody
JNK1A2 antibody
JNK2 antibody
JNK21B1/2 antibody
JNK2A antibody
JNK2ALPHA antibody
JNK2B antibody
JNK2BETA antibody
JNK3 alpha protein kinase antibody
JNK3 antibody
JNK3A antibody
Jun kinase antibody
JUN N terminal kinase antibody
MAP kinase 10 antibody
MAP kinase 8 antibody
MAP kinase 9 antibody
MAP kinase p49 3F12 antibody
MAPK 10 antibody
MAPK 8 antibody
MAPK 9 antibody
MAPK10 antibody
mapk8 antibody
MAPK9 antibody
Mitogen activated protein kinase 10 antibody
Mitogen activated protein kinase 8 antibody
Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody
Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody
Mitogen activated protein kinase 9 antibody
Mitogen-activated protein kinase 8 antibody
MK08_HUMAN antibody
p493F12 antibody
p54a antibody
p54aSAPK antibody
p54bSAPK antibody
PRKM10 antibody
PRKM8 antibody
PRKM9 antibody
SAPK antibody
SAPK(beta) antibody
SAPK1 antibody
SAPK1a antibody
SAPK1b antibody
SAPK1c antibody
Stress activated protein kinase 1 antibody
Stress activated protein kinase 1a antibody
Stress activated protein kinase 1b antibody
Stress activated protein kinase 1c antibody
Stress activated protein kinase beta antibody
Stress activated protein kinase JNK1 antibody
Stress activated protein kinase JNK2 antibody
Stress activated protein kinase JNK3 antibody
Stress-activated protein kinase 1c antibody
Stress-activated protein kinase JNK1 antibody
数据库入口号Swiss-Prot#:P45983
计算分子量46/54 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
ICC: 1:50-1:200
Western blot analysis of JNK1+JNK2+JNK3 on different cell lysates using anti-JNK1+JNK2+JNK3 antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: PC12
Lane 3: K562
Lane 5: HepG2
Lane 6: Human lung
Western blot analysis of JNK1+JNK2+JNK3 on hybrid fish (crucian-carp) brain tissue lysate using anti-JNK1+JNK2+JNK3 antibody at 1/500 dilution.
ICC staining JNK1+JNK2+JNK3 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.
背景文献
1. Cantrell, M. et al. 2015. c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression. Oncotarget. 6: 11863-11881.
2. Marampon, F. et al. 2015. Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. Journal of endocrinological investigation.
如果您使用该产品48615发表了文章，请通知我们，让我们可以引用您的文献。
et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681,
, (2021),
PMID: 33604681
Yes
