产品详情
产品名称Integrin alpha 6 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性SR45-00
纯化ProA affinity purified
应用WB, IHC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名Alpha6p antibody
CD49 antigen-like family member F antibody
CD49f antibody
Integrin alpha6B antibody
Integrin, alpha 6 antibody
ITA6_HUMAN antibody
ITGA6 antibody
ITGA6B antibody
Processed integrin alpha-6 antibody
VLA 6 antibody
VLA-6 antibody
数据库入口号Swiss-Prot#:P23229
计算分子量127 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
IHC: 1:50-1:200
背景
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
背景文献
1. Russell, A.J., et al. 2003. α6/β4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of α3/β1 Integrin. J. Cell Sci. 116: 3543-3556.
2. Kazarov, A.R., et al. 2002. An extracellular site on tetraspanin CD151 determines α3 and α6 Integrin-dependent cellular morphology. J. Cell Biol. 158: 1299-1309.