产品详情
产品名称IFNAR1 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性SR45-08
纯化ProA affinity purified
应用WB, IP, IHC, FC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名Alpha type antiviral protein antibody
AVP antibody
Beta type antiviral protein antibody
CRF2-1 antibody
Cytokine receptor class-II member 1 antibody
Cytokine receptor family 2 member 1 antibody
IFN alpha REC antibody
IFN alpha receptor antibody
IFN alpha/beta Receptor alpha antibody
IFN beta receptor antibody
IFN-alpha/beta receptor 1 antibody
IFN-R-1 antibody
IFNAR antibody
Ifnar1 antibody
IFNBR antibody
IFRC antibody
INAR1_HUMAN antibody
Interferon (alpha beta and omega) receptor 1 antibody
Interferon alpha/beta receptor 1 antibody
Interferon alpha/beta receptor alpha chain antibody
Interferon beta receptor 1 antibody
Type I interferon receptor 1 antibody
数据库入口号Swiss-Prot#:P17181
计算分子量90/130 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC:1:50-1:200
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IFNAR1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-IFNAR1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-IFNAR1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-IFNAR1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Jurkat cells with IFNAR1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
背景
The type I interferons (IFNs), α and β, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The α and β IFNs appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFNγ) binds to a distinct receptor. The latter protein, IFN-αR, is only weakly responsive to type I interferons in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-? subtypes. Moreover, IFN-α/βR is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. IFN-αR1 is a receptor for IFN-α/β and is present as the full chain (IFN-αR1a) and as a splice-variant (IFN-αR1). The IFN-γ receptor complex consists of an alpha subunit (IFN-γRα) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).
背景文献
1. Chandra PK et al. Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosis. PLoS One 9:e108616 (2014).
2. Wan S et al. Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells. PLoS One 7:e32542 (2012).