产品详情
产品名称Integrin beta 3 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性SJ19-09
纯化ProA affinity purified
应用WB, IHC, ICC/IF
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名BDPLT16 antibody
BDPLT2 antibody
CD 61 antibody
CD61 antibody
CD61 antigen antibody
GP3A antibody
GPIIIa antibody
GT antibody
HPA 1 antibody
HPA 4 antibody
Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody
Integrin beta chain beta 3 antibody
Integrin beta-3 antibody
ITB3_HUMAN antibody
ITG B3 antibody
ITGB 3 antibody
ITGB3 antibody
NAIT antibody
Platelet fibrinogen receptor beta subunit antibody
Platelet fibrinogen receptor, beta subunit antibody
Platelet glycoprotein IIIa antibody
Platelet glycoprotein IIIa precursor antibody
Platelet membrane glycoprotein IIIa antibody
PTP antibody
数据库入口号Swiss-Prot#:P05106
计算分子量87 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
背景
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
背景文献
1. Klausen C et al. Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin. Mol Cancer Res 7:1425-37 (2009).
2. Liu, J. et al. The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation. Journal of cell science 128: 1718-31(2015).