产品详情
产品名称IgG4 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性ST05-12
纯化ProA affinity purified
应用WB, IHC
种属反应性Hu
免疫原描述recombinant protein
别名Ig gamma 4 chain C region antibody IGHG4 antibody Immunoglobulin heavy constant gamma 4 (G4m marker) antibody MGC117419 antibody
数据库入口号Swiss-Prot#:P01861
计算分子量36 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-5,000
IHC: 1:50-1:200
Western blot analysis of IgG4 on human plasma lysates using anti-IgG4 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IgG4 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-IgG4 antibody. Counter stained with hematoxylin.
背景
The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Several studies have shown that a large population of patients with recurrent respiratory tract infection have low IgG4 concentrations.
背景文献
1. Ma JM et al. Clinical research on benign lymphoepithelial lesions of lacrimal gland in 20 Chinese patients. Chin Med J (Engl) 128:493-8 (2015). 2. Zhang R et al. Clinicopathological analysis of 12 patients with autoimmune pancreatitis. Exp Ther Med 10:121-126 (2015).
Yes
