产品详情
产品名称FGFR2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性JM10-60
纯化ProA affinity purified
应用WB, IP
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
别名bacteria-expressed kinase antibody
BBDS antibody
BEK antibody
BEK fibroblast growth factor receptor antibody
BFR1 antibody
CD332 antibody
CD332 antigen antibody
CEK3 antibody
CFD1 antibody
Craniofacial dysostosis 1 antibody
ECT1 antibody
FGF receptor antibody
FGFR 2 antibody
FGFR-2 antibody
Fgfr2 antibody
FGFR2_HUMAN antibody
Fibroblast growth factor receptor 2 antibody
Hydroxyaryl protein kinase antibody
Jackson Weiss syndrome antibody
JWS antibody
K SAM antibody
K-sam antibody
Keratinocyte growth factor receptor 2 antibody
Keratinocyte growth factor receptor antibody
KGFR antibody
KSAM antibody
protein tyrosine kinase, receptor like 14 antibody
soluble FGFR4 variant 4 antibody
TK14 antibody
TK25 antibody
数据库入口号Swiss-Prot#:P21802
计算分子量145 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IP: 1:10-1:50
背景
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also designated K-sam) maps to chromosome 10q26.13 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome..
背景文献
1. Ramsey MR et al. FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest 123:3525-38 (2013).
2. Huang Y et al. Twist1- and twist2-haploinsufficiency results in reduced bone formation. PLoS One 9:e99331 (2014).