CD11b Rabbit mAb - SAB | Signalway Antibody

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CD11b Rabbit mAb#49692

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Recombinant

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产品详情

产品名称CD11b Rabbit mAb

克隆性JU93-81

纯化ProA affinity purified

应用WB,ICC,IF,IP,IHC,FC

种属反应性Hu Ms Rt

免疫原描述Recombinant protein

别名antigen CD11b (p170) antibody
Antigen CD11b p170 antibody
CD11 antigen like family member B antibody
CD11 antigen-like family member B antibody
CD11b antibody
CD11b/CD18 antibody
CD49d antibody
Cell surface glycoprotein MAC-1 subunit alpha antibody
Complement component 3 receptor 3 subunit antibody
Complement Component Receptor 3 Alpha antibody
Complement receptor type 3, alpha subunit antibody
CR 3 alpha chain (CR3A) antibody
CR 3 alpha chain antibody
CR-3 alpha chain antibody
CR3 antibody
CR3A antibody
F730045J24Rik antibody
Integrin Alpha M antibody
Integrin alpha M chain antibody
Integrin alpha-M antibody
Integrin beta 2 alpha subunit antibody
Integrin subunit alpha M antibody
integrin, alpha M (complement component 3 receptor 3 subunit) antibody
ITAM_HUMAN antibody
ITGAM antibody
Leukocyte adhesion receptor MO1 antibody
Ly-40 antibody
MAC 1 antibody
Mac-1a antibody
MAC1 antibody
Mac1, alpha subunit antibody
MAC1A antibody
Macrophage antigen alpha polypeptide antibody
MGC117044 antibody
Mo1, alpha subunit antibody
MO1A antibody
Neutrophil adherence receptor alpha M subunit antibody
Neutrophil adherence receptor antibody
SLEB6 antibody

数据库入口号Swiss-Prot#:P11215

计算分子量170 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情

IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD11b antibody. Counter stained with hematoxylin.

Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD11b antibody. Counter stained with hematoxylin.

ICC staining CD11b in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Flow cytometric analysis of THP-1 cells with CD11b antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

Western blot analysis of CD11b expression in RAW264.7 cell lysate.

背景

Integrin αM, also designated complement component receptor-3 α, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin αM combines with the Integrin β2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin αM/β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

背景文献

1. Yu F et al. Repetitive Model of Mild Traumatic Brain Injury Produces Cortical Abnormalities Detectable by Magnetic Resonance Diffusion Imaging, Histopathology, and Behavior. J Neurotrauma 34:1364-1381 (2017).
2. Surolia R et al. 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. JCI Insight 2:e91377 (2017).

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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CD11b Rabbit mAb#49692

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