产品详情
产品名称WSTF Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性JG36-32
纯化ProA affinity purified
应用WB,FC
种属反应性Hu, Ms, Rt
别名baz1b antibody
BAZ1B_HUMAN antibody
Bromodomain adjacent to zinc finger domain protein 1B antibody
hWALP 2 antibody
hWALP-2 antibody
hWALP2 antibody
transcription factor WSTF antibody
Tyrosine-protein kinase BAZ1B antibody
WALP-2 antibody
WALP2 antibody
WBRS 9 antibody
WBRS-9 antibody
WBRS9 antibody
WBSC 10 antibody
WBSC-10 antibody
WBSC10 antibody
WBSCR10 antibody
WBSCR9 antibody
Williams Beuren syndrome chromosome region 9 protein antibody
Williams syndrome transcription factor antibody
Williams-Beuren syndrome chromosomal region 10 protein antibody
Williams-Beuren syndrome chromosomal region 9 protein antibody
WSTF antibody
数据库入口号Swiss-Prot#:Q9UIG0
计算分子量171 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1,000
FC: 1:50-1:100
背景
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
背景文献
1. Cook P.J. et al. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458:591-596(2009).
2. Xiao A. et al. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457:57-62(2009).