产品详情
产品名称OS9 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性JG38-07
纯化ProA affinity purified
应用WB,IHC,IP
种属反应性Hu, Ms, Rt
免疫原描述Recombinant protein of C-terminal Human OS9.
别名Amplified in osteosarcoma 9 antibody
amplified in osteosarcoma antibody
ERLEC2 antibody
OS-9 antibody
Os9 antibody
OS9_HUMAN antibody
Osteosarcoma amplified 9 endoplasmic reticulum lectin antibody
Protein OS-9 antibody
数据库入口号Swiss-Prot#:Q13438
计算分子量76 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:2,000
IHC: 1:50-1:200
IP: 1:10-1:50
Western blot analysis of OS9 on mouse testis and rat testis tissue lysates using anti-OS9 antibody at 1/2,000 dilution.
Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-OS9 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-OS9 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-OS9 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-OS9 antibody. Counter stained with hematoxylin.
背景
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.
背景文献
1. Wang Y et al. OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem 282:36561-36570 (2007).
2. Bernasconi R et al. A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. J Biol Chem 283:16446-16454 (2008).
Yes
