产品详情
产品名称FKBP52 Rabbit mAb
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
克隆性JG96-30
纯化ProA affinity purified
应用WB,ICC,IHC,FC
种属反应性Hu, Ms
免疫原描述Recombinant protein within human FKBP52 aa 1-200.
别名51 kDa FK506-binding protein antibody
52 kDa FK506 binding protein antibody
52 kDa FK506-binding protein antibody
52 kDa FKBP antibody
59 kDa immunophilin antibody
FK506 binding protein 4 antibody
FK506-binding protein 4 antibody
FKBP 4 antibody
FKBP 52 antibody
FKBP 59 antibody
FKBP-4 antibody
FKBP-52 antibody
FKBP4 antibody
FKBP4_HUMAN antibody
FKBP51 antibody
FKBP52 protein antibody
FKBP59 antibody
HBI antibody
Hsp 56 antibody
HSP binding immunophilin antibody
HSP-binding immunophilin antibody
Hsp56 antibody
Immunophilin FKBP52 antibody
N-terminally processed antibody
p52 antibody
p59 antibody
p59 protein antibody
Peptidyl prolyl cis trans isomerase antibody
Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
Peptidylprolyl cis trans isomerase antibody
PPIase antibody
PPIase FKBP4 antibody
Rotamase antibody
T cell FK506 binding protein 59kD antibody
数据库入口号Swiss-Prot#:Q02790
计算分子量52 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of FKBP52 on 293 (1) and SK-Br-3 (2) cell lysate using anti-FKBP52 antibody at 1/2,000 dilution.
Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue using anti-FKBP52 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human esophagus tissue using anti-FKBP52 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-FKBP52 antibody. Counter stained with hematoxylin.
ICC staining FKBP52 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining FKBP52 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of 293T cells with FKBP52 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
背景
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
背景文献
1. Peattie D A et al. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc Natl Acad Sci USA 89:10974-10978 (1992).
2. Tai P-K K et al. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256:1315-1318 (1992).
Yes
