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位置： 首页 > 重组兔单抗 > Fbx32 Rabbit mAb

Fbx32 Rabbit mAb#49987

评价
Recombinant
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Fbx32 Rabbit mAb
Fbx32 Rabbit mAb
Fbx32 Rabbit mAb
是否有货： Yes
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产品详情

产品名称Fbx32 Rabbit mAb

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

克隆性JE41-27

纯化ProA affinity purified

应用WB,ICC

种属反应性Hu, Ms, Rt

免疫原描述Recombinant protein corresponding to human Fbx32 1-200aa.

别名4833442G10Rik antibody
AI430017 antibody
Atrogin 1 antibody
Atrogin-1 antibody
ATROGIN1 antibody
Atrophy gene 1 antibody
F box only protein 32 antibody
F-box only protein 32 antibody
F-box protein 32 antibody
FBX32_HUMAN antibody
fbxo25 antibody
FBXO32 antibody
FLJ32424 antibody
MAFbx antibody
MGC108443 antibody
MGC137646 antibody
MGC33610 antibody
Muscle atrophy F box antibody
Muscle atrophy F box protein antibody
Muscle atrophy F-box protein antibody

数据库入口号Swiss-Prot#:Q969P5

计算分子量41 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:500-1:1,000

ICC: 1:50-1:200

Western blot analysis of Fbx32 on mouse skeletal muscle tissue using anti-Fbx32 antibody at 1/1,000 dilution.
ICC staining Fbx32 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Fbx32 in L6 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Muscle atrophy F-box (MAFbx) is an E3 ubiquitin ligase that initiates ATP-dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. MAFbx transcript is abundant in cardiac and skeletal muscle undergoing atrophy. MAFbx -/- mice are resistant to muscle atrophy. MAFbx is thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. It interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. MAFbx is specifically expressed in cardiac and skeletal muscle.
背景文献
1. Julie L C et al. Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1. FEBS Lett 586:362-367 (2012).
2. Al-Hassnan Z N et al. A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy. BMC Med Genet 17:3-3 (2016).

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5

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注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡

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