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位置: 首页 > 抗体 > Bile acid receptor Polyclonal Antibody

Bile acid receptor Polyclonal Antibody#42665

Bile acid receptor Polyclonal Antibody
是否有货: 货期1周
产品总价:
产品详情

产品名称Bile acid receptor Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Caprylic Acid Ammonium Sulfate Precipitation purified

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of total Bile acid receptor polyclonal antibody.

免疫原类型protein

免疫原描述Recombinant human Bile acid receptor protein

基因/蛋白名称Bile acid receptor

别名Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14

数据库入口号Swiss-Prot#: Q96RI1

UniprotQ96RI1

计算分子量56kd

配方Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

保存Store at -20˚C

应用详情
Western blotting: 1:500 - 1:1000
All lanes: Bile acid receptor antibody at 2ug/ml+mouse stomach tissue secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size :56kDa observed band size :56kDa
背景
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
背景文献
[1]"Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates."Lundquist J.T., Harnish D.C., Kim C.Y., Mehlmann J.F., Unwalla R.J., Phipps K.M., Crawl

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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